mitochondrial is an enzyme that in humans is encoded by the ALDH2 gene located on chromosome 12. ALDH2 belongs to the aldehyde dehydrogenase family of enzymes...

"Asian glow".[citation needed] Around 20–30% of East Asians carry the rs671 (ALDH2*2) allele on chromosome 12, which results in a less functional acetaldehyde...

In all three classes, constitutive and inducible forms exist. ALDH1 and ALDH2 are the most important enzymes for aldehyde oxidation, and both are tetrameric...

there are three known genes which encode this enzymatic activity, ALDH1A1, ALDH2, and the more recently discovered ALDH1B1 (also known as ALDH5). These enzymes...

vessels. Individuals that have the ALDH2*2 allele, a variant that has a mutation when compared to the wild-type ALDH2 isozyme, are known to have higher...

ALDH2*2, and ALDH2*504lys. In the overall Japanese population, about 57% of individuals are homozygous for the normal allele (sometimes termed ALDH2*1)...

investigated in native Japanese who have a variant ALDH2 allele termed glu487lys, ALDH2*2 or ALDH2*504lys, which is a single nucleotide polymorphism allele...

another allele responsible for the flush reaction, the rs671 (ALDH2*2) of the ALDH2 is rare among Europeans and Sub-Saharan Black Africans, while 30%...

human ALDH2. Alda-1 has been proposed as a potential treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2. Ethanol...

is performed by aldehyde dehydrogenase (ALDH) enzymes. A mutation in the ALDH2 gene that encodes for an inactive or dysfunctional form of this enzyme affects...

acetate mainly by aldehyde dehydrogenase (ALDH). ALDH2 is an isozyme of ALDH and ALDH2 has a polymorphism (ALDH2*2, Glu487Lys) that makes ADLH2 inactive; this...

conversion was only discovered to be mitochondrial aldehyde dehydrogenase (ALDH2) in 2002. Nitroglycerin is available in sublingual tablets, sprays, ointments...

now operating in the opposite direction. Many East Asian people have an ALDH2 mutation which makes them significantly less efficient at oxidizing acetaldehyde...

Sinica found that genes in alcohol metabolism pathway, especially ADH1B and ALDH2, conferred the major genetic risk for alcohol dependence in Taiwanese Han...

metabolizes ethanol to acetaldehyde too quickly for further processing by ALDH2 and thereby leads to the accumulation of acetaldehyde and rhinitis symptoms...

in genes that encode the main enzymes of alcohol metabolism, ADH1B and ALDH2. These genetic factors influence the rate at which alcohol and its initial...

descent. According to the analysis by HapMap Project, the rs671 allele of the ALDH2 gene responsible for the flush reaction is rare among Europeans and Africans...

Chou SH, Wu IC, et al. (March 2008). "Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the...

is catabolized by alcohol dehydrogenase ADH5 and aldehyde dehydrogenase ALDH2. Formaldehyde is a building block in the synthesis of many other compounds...

drinking may be due to the presence of the aldehyde dehydrogenase gene (ALDH2, Chromosome 12) in many (but by no means the vast majority) that results...

Increased activity of the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) has been shown to have a protective effect against cardiac ischemia in...

effect of APOE on Alzheimer's disease, and CHRNA5 on smoking behaviour, and ALDH2 (in individuals of East Asian ancestry) on alcohol use. On the other hand...

useful, but the root being likely harmful, as the latter is an inhibitor of ALDH2. Artichoke: Research shows that artichoke extract does not prevent the signs...

both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2, further process the immediate metabolites of histamine for excretion or...

original (PDF) on March 27, 2011. Eng, MY; Luczak, SE; Wall, TL (2007). "ALDH2, ADH1B, and ADH1C genotypes: A literature review". Alcohol Research & Health...

resistance). G6PD deficiency is the second most common human enzyme defect after ALDH2 deficiency, being present in more than 400 million people worldwide. G6PD...

Miyamori; et al. (2015). "Tracing Jomon and Yayoi ancestries in Japan using ALDH2 and JC virus genotype distributions". Investigative Genetics. 6 (14): 14...

Griseofulvin (weak evidence) Hydrazines Isoniazid: causes headache via a non-ALDH2 mechanism Procarbazine Ketoconazole (weak evidence) Macrolide immunosuppressants...

that this reaction is catalysed by mitochondrial aldehyde dehydrogenase (ALDH2 or mtALDH). The NO produced by this process is a potent activator of guanylyl...

in the metabolism of ethanol. It has been shown that a mutation in the ALDH2 gene (one of 19 aldehyde dehydrogenase genes) is what leads to the common...