ATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals represents an important step in fatty acid biosynthesis. By converting...
13 KB (1,471 words) - 11:45, 12 March 2024
and oxaloacetate by the enzyme ATP citrate lyase (ACL). This principal reaction is coupled with the hydrolysis of ATP. At low glucose levels: CoA is acetylated...
22 KB (2,106 words) - 13:45, 19 July 2024
Dyslipidemia (section ATP citrate lyase inhibitors)
synthesis pathway upstream of statins at ATP citrate lyase. This enzyme synthesizes acetyl-CoA using citrate from the mitochondria. Cholesteryl ester...
30 KB (2,961 words) - 13:47, 30 May 2024
the enzyme SLC27A2 in the liver. The activated substance inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream...
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injury, a common sports injury Anti-cardiolipin antibodies ATP citrate synthase, or ATP citrate lyase, an enzyme ACL Cables, a cable manufacturing company in...
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Citric acid cycle (redirect from Citrate cycle)
mitochondrial membrane into the cytosol. There it is cleaved by ATP citrate lyase into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to mitochondrion...
56 KB (6,064 words) - 22:31, 10 July 2024
acetyl-CoA and then into citrate. Excess citrate is exported from the mitochondrion back into the cytosol, where ATP citrate lyase regenerates acetyl-CoA...
81 KB (8,708 words) - 04:39, 10 July 2024
target enzymes involved in lipogenesis, such as citrate/isocitrate carrier (CIC), ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC) and fatty acid...
2 KB (153 words) - 07:00, 3 December 2023
related enzymes 2-methylcitrate synthase EC 2.3.3.5 and ATP citrate lyase EC 2.3.3.8. Citrate synthase is a member of a small family of enzymes that can...
5 KB (602 words) - 16:39, 30 December 2023
inner mitochondrial membrane into the cytosol. There it is cleaved by ATP citrate lyase into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to...
54 KB (4,978 words) - 14:13, 19 July 2024
of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 (3): 645–50. doi:10.1111/j.1432-1033.1982.tb06731...
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2013 homozygous familial hypercholesterolemia.). Bempedoic acid, an ATP citrate lyase inhibitor ATC code C10 Alenghat, Francis J.; Davis, Andrew M. (2019)...
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available in U.S. pharmacies. Further products include NILEMDO (also a ATP Citrate Lyase inhibitor like NEXLETOL) and NUSTENDI (bempedoic acid and ezetimibe...
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inner mitochondrial membrane into the cytosol. There it is cleaved by ATP citrate lyase into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to...
50 KB (5,557 words) - 08:08, 10 July 2024
inner mitochondrial membrane into the cytosol. There it is cleaved by ATP citrate lyase into acetyl-CoA and oxaloacetate. The oxaloacetate can be used for...
41 KB (4,743 words) - 16:42, 11 July 2024
converted into acetyl-CoA, ADP, CO2, and oxaloacetate by ATP-citrate lyase, together with ATP and CoASH as substrates. Three acetyl-CoAs are converted into...
32 KB (4,066 words) - 17:16, 22 June 2024
use as chirons. (-)-HCA is a competitive inhibitor of ATP citrate lyase, which converts citrate into oxaloacetate and acetyl CoA. The reverse of this...
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the citrate–malate shuttle. The new metabolic pathway consists of mitochondrial transport proteins and several enzymes, including ATP-citrate lyase (ACLY)...
26 KB (2,998 words) - 01:41, 25 March 2024
enzymology, a [citrate (pro-3S)-lyase] ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction ATP + acetate + citrate (pro-3S)-lyase(thiol form)...
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exploiting both Calvin Benson cycle and reverse TCA cycle (with an unusual ATP citrate lyase) according to availability of carbon resources and whether it is free...
56 KB (6,309 words) - 03:05, 12 May 2024
of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 (3): 645–50. doi:10.1111/j.1432-1033.1982.tb06731...
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2Fdred + 2H+ ⇌ pyruvate + CoA + 2Fdox ATP citrate lyase: ACL, acetyl-CoA + oxaloacetate + ADP + Pi ⇌ citrate + CoA + ATP α-keto-glutarate:ferredoxin oxidoreductase:...
32 KB (3,209 words) - 06:16, 27 April 2024
NAD(P)+}}} Citrate converted into oxaloacetate and acetyl-CoA, this is an ATP dependent step and the key enzyme is the ATP citrate lyase Citrate + ATP + CoA...
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Triphosphoribosyl-dephospho-CoA synthase (redirect from ATP:3'-dephospho-CoA 5-triphosphoribosyltransferase)
Dimroth P, Bott M (2000). "Biosynthesis of the prosthetic group of citrate lyase". Biochemistry. 39 (31): 9438–50. doi:10.1021/bi000401r. PMID 10924139...
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sequence homology between the CCL protein and the C-terminal region of ATP citrate lyase (ACL), an enzyme commonly employed by the reductive TCA cycle. Parte...
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increases from 0.6 to 1.0, the citrate lyase and phosphoribosyl pyrophosphate synthetase, two enzymes controlling anabolic (ATP-demanding) pathways are activated...
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There are three enzymes specific to the reductive citric acid cycle – citrate lyase, fumarate reductase, and α-ketoglutarate synthase.[citation needed]...
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tricarboxylic acid cycle enzymes, albeit without the key enzyme, ATP citrate lyase, that would enable the pathway to operate reductively. Unusually for...
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List of EC numbers (EC 4) (redirect from Phosphorus-oxygen lyases)
synthase EC 4.1.3.6: citrate (pro-3S)-lyase EC 4.1.3.7: Now EC 2.3.3.1, citrate (Si)-synthase EC 4.1.3.8: Now EC 2.3.3.8, ATP citrate synthase EC 4.1.3.9:...
62 KB (7,931 words) - 19:04, 4 January 2024
citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalyzed by citrate synthase. It is also involved in gluconeogenesis, the urea cycle...
12 KB (1,159 words) - 10:09, 7 July 2024