• Actinin is a microfilament protein. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and...
    13 KB (1,649 words) - 05:05, 3 June 2024
  • Thumbnail for Alpha-actinin-3
    Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the...
    13 KB (1,581 words) - 14:02, 19 January 2024
  • Thumbnail for Alpha-actinin-1
    Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse...
    12 KB (1,374 words) - 04:19, 8 March 2024
  • Thumbnail for Alpha-actinin-2
    Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal...
    21 KB (2,601 words) - 17:21, 3 December 2023
  • Thumbnail for Alpha-actinin-4
    Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse...
    12 KB (1,455 words) - 04:22, 8 March 2024
  • Thumbnail for Smooth muscle
    Z-discs in striated muscle sarcomeres. Dense bodies are rich in alpha-actinin (α-actinin), and also attach intermediate filaments (consisting largely of vimentin...
    37 KB (4,738 words) - 20:27, 18 July 2024
  • Thumbnail for Eukaryote
    structures are microfilaments of actin and actin-binding proteins, including α-actinin, fimbrin, and filamin are present in submembranous cortical layers and...
    61 KB (6,130 words) - 18:03, 20 September 2024
  • Thumbnail for Gene doping
    growth factor, fibroblast growth factor, endorphin, enkephalin and alpha-actinin-3. The risks of gene doping would be similar to those of gene therapy:...
    32 KB (3,911 words) - 03:05, 15 September 2024
  • Thumbnail for Edema
    occludin, claudins, tight junction protein ZO-1, cadherins, catenins and actinin, which are directed by intracellular signal chains, in particular in connection...
    30 KB (3,283 words) - 16:40, 26 August 2024
  • monomers, or polymers, or both. Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding...
    10 KB (886 words) - 06:35, 18 March 2024
  • Thumbnail for Keratin
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    39 KB (3,017 words) - 13:44, 1 September 2024
  • Thumbnail for Adherens junction
    studies.[citation needed] Tight junction Pardo, JV, Craig, SW (1979). "alpha-Actinin localization in the junctional complex of intestinal epithelial cells"...
    5 KB (505 words) - 05:55, 18 April 2024
  • Thumbnail for PDLIM3
    intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 and also appears to be essential for right ventricular chamber formation...
    12 KB (1,442 words) - 01:33, 10 March 2024
  • Thumbnail for PDLIM1
    encoded by the PDLIM1 gene. PDLIM1 has been shown to interact with: Actinin alpha 4, Actinin, alpha 1, Estrogen receptor alpha, and RNF12. GRCh38: Ensembl release...
    8 KB (1,069 words) - 11:40, 17 October 2022
  • channel activities that are substantially augmented by alpha-actinin. The TRPP3-alpha-actinin association was documented by co-immunoprecipitation using...
    11 KB (1,385 words) - 04:58, 3 September 2023
  • Thumbnail for Microfilament
    Actin-Related Protein-2/3 (or Arp2/3) complex Filament cross-linkers (e.g., α-actinin, fascin, and fimbrin) Actin monomer-binding proteins profilin and thymosin...
    21 KB (2,785 words) - 17:16, 15 June 2024
  • Thumbnail for Sarcomere
    molecules are cross-linked in the Z-disc via the Z-line protein alpha-actinin. The M-band proteins myomesin as well as C-protein crosslink the thick...
    12 KB (1,553 words) - 02:34, 3 September 2024
  • Thumbnail for Titin
    The N-terminal (the Z-disc end) contains a "Z repeat" that recognizes Actinin alpha 2. The elasticity of the PEVK region has both entropic and enthalpic...
    45 KB (4,680 words) - 16:38, 13 September 2024
  • Thumbnail for Intermediate filament
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    30 KB (3,168 words) - 14:29, 25 April 2024
  • cell bodies and processes at both ends containing actin, myosin and actinin, giving mesangial cells contractile properties. The anchoring filaments...
    14 KB (1,601 words) - 02:15, 3 December 2023
  • ECM components, and intracellularly to microfilament-binding proteins α-actinin and talin to link the cytoskeleton with the outside. Integrins also serve...
    25 KB (2,724 words) - 18:06, 10 August 2024
  • Thumbnail for Cytoskeleton
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    45 KB (5,121 words) - 06:34, 27 May 2024
  • Thumbnail for Troponin I
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    18 KB (2,156 words) - 03:32, 22 July 2024
  • Thumbnail for Tubulin
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    32 KB (3,393 words) - 05:32, 15 June 2024
  • Thumbnail for Troponin T
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    6 KB (631 words) - 20:38, 19 April 2024
  • Thumbnail for Extracellular matrix
    signaling proteins (adhesion kinase (FAK), talin, vinculin, paxillin, α-actinin, GTPases etc.) which cause changes in cell shape and actomyosin contractility...
    36 KB (4,084 words) - 22:32, 26 September 2024
  • Thumbnail for Microtubule
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    64 KB (7,838 words) - 19:01, 10 September 2024
  • Thumbnail for Kinesin
    Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin...
    36 KB (4,235 words) - 15:35, 20 September 2024
  • Thumbnail for Focal adhesion
    integrin binds to the cytoskeleton via adapter proteins such as talin, α-actinin, filamin, vinculin and tensin. Many other intracellular signalling proteins...
    12 KB (1,528 words) - 06:12, 1 September 2024
  • Thumbnail for Integrin
    many cytoplasmic proteins, such as talin, vinculin, paxillin, and alpha-actinin. These act by regulating kinases such as FAK (focal adhesion kinase) and...
    36 KB (3,929 words) - 18:22, 21 September 2024