(cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene. The protein is a CXC chemokine receptor. CXCR-4 is an alpha-chemokine...
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A CXCR4 antagonist is a substance which blocks the CXCR4 receptor and prevent its activation. Blocking the receptor stops the receptor's ligand, CXCL12...
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receptor, CXCR4, for entry. Dual-tropic HIV-1 strains are thought to be transitional strains of HIV-1 and thus are able to use both CCR5 and CXCR4 as co-receptors...
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from autosomal dominant mutations in the gene for the chemokine receptor, CXCR4, resulting in a carboxy-terminus truncation of the receptor of between 10...
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marrow through a CXCR4 dependent mechanism. CXCR4, previously called LESTR or fusin, is the receptor for CXCL12. This CXCL12-CXCR4 interaction used to...
26 KB (2,934 words) - 14:13, 25 August 2024
CXC chemokine receptors (section CXCR4)
has three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11. CXCR4 (also known as fusin) is the receptor for a chemokine known as CXCL12 (or...
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development. HIV-1 most commonly uses the chemokine receptors CCR5 and/or CXCR4 as co-receptors to enter target immunological cells. These receptors are...
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alpha-chemokine receptor, CXCR4, for entry. These strains are now called X4 viruses. The alpha-chemokine SDF-1, a ligand for CXCR4, suppresses replication...
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partial agonist) of the alpha chemokine receptor CXCR4 and an allosteric agonist of CXCR7. The CXCR4 alpha-chemokine receptor and one of its ligands,...
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mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients). CXCR4 mutations cause symptomatic hyperviscosity syndrome and high...
59 KB (5,784 words) - 03:48, 13 July 2024
caused by a gain-of-function mutation of the chemokine receptor CXCR4. The mutation in CXCR4 increases signaling because it disrupts negative regulatory elements...
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Mohammed; et al. (31 August 2022). "Mavorixafor, an Orally Bioavailable CXCR4 Antagonist, Increases Immune Cell Infiltration and Inflammatory Status of...
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the surface of CD4+ cells and macrophages, called a chemokine co-receptor CXCR4, another chemokine co-receptor found on CD4+ cells gp41, an HIV protein...
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(against CXCL10) CXCR4 Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4) CXCR5 Agonists:...
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the expression of CD20 (target of rituximab/ofatumumab) by targeting the CXCR4/SDF1 axis. Together, these data are consistent with a mechanistic model...
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myelokathexis. A gain-of-function mutation resulting in a truncated form of CXCR4 is believed to be its cause. The truncated form of the receptor has a 2-fold...
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is 25–30%. Retrospective research showed that two chemokine receptors, CXCR4 and CXCR7, can be used as molecular prognosis factors. People who express...
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Zhang L, Qiao A, Watson K, Zhang J, Fan GH (February 2008). "Activation of CXCR4 triggers ubiquitination and down-regulation of major histocompatibility...
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processes (including vascular endothelial growth factor receptors type 1 and 2, CXCR4, and Tie-2) as well as evidence that the "intermediate" subset is specifically...
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Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J (2015). "CXCR4(+)CD45(-) BMMNC subpopulation is superior to unfractionated BMMNCs for protection...
34 KB (3,634 words) - 08:49, 6 August 2024
only recently coming to light. It may be mediated by interaction through CXCR4 (CD184) the receptor for CXC Chemokines (e.g., SDF1) and α4β1 integrins...
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mice and protected against systemic platelet activation and thrombosis. A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells. A PAR1 pepducin...
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famous and well-studied of the CCR family is CCR5 (and its near-homologue CXCR4) which acts as the primary co-receptor for HIV viral infection. The HIV...
21 KB (3,129 words) - 10:03, 2 June 2024
(against CXCL10) CXCR4 Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4) CXCR5 Agonists:...
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along with the CD4-gp120 complex to enter the target cells - either CCR5 or CXCR4. This demonstrates an example of how cell surface receptors can affect the...
21 KB (2,537 words) - 07:13, 13 August 2024
downstream from NF-κB activation leading to decreased chemokine receptor CXCR4 signaling causing reduced inflammation. Despite the efficiency of treating...
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activated target CXCR4 gene in K562 cell lines. Comparing with the dCas9-VP64 activation complex, they were able to increase the CXCR4 gene expression...
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expressed on the host cell. These co-receptors are chemokine receptors CCR5 or CXCR4. Following a structural change in another viral protein (gp41), HIV inserts...
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targets for drug therapy, one of them being the viral entry pathway. CCR5 and CXCR4 are the main receptors involved in the HIV entry process. These receptors...
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relationship between HHV-7 and HIV-1 co-receptors CXCR4 and CCR5. During infection, HHV-7 causes a loss of CXCR4 in CD4+ T-cells in addition to lowering intracellular...
32 KB (3,729 words) - 22:52, 24 August 2024