(cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene. The protein is a CXC chemokine receptor. CXCR-4 is an alpha-chemokine...

A CXCR4 antagonist is a substance which blocks the CXCR4 receptor and prevent its activation. Blocking the receptor stops the receptor's ligand, CXCL12...

receptor, CXCR4, for entry. Dual-tropic HIV-1 strains are thought to be transitional strains of HIV-1 and thus are able to use both CCR5 and CXCR4 as co-receptors...

from autosomal dominant mutations in the gene for the chemokine receptor, CXCR4, resulting in a carboxy-terminus truncation of the receptor of between 10...

marrow through a CXCR4 dependent mechanism. CXCR4, previously called LESTR or fusin, is the receptor for CXCL12. This CXCL12-CXCR4 interaction used to...

has three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11. CXCR4 (also known as fusin) is the receptor for a chemokine known as CXCL12 (or...

development. HIV-1 most commonly uses the chemokine receptors CCR5 and/or CXCR4 as co-receptors to enter target immunological cells. These receptors are...

alpha-chemokine receptor, CXCR4, for entry. These strains are now called X4 viruses. The alpha-chemokine SDF-1, a ligand for CXCR4, suppresses replication...

partial agonist) of the alpha chemokine receptor CXCR4 and an allosteric agonist of CXCR7. The CXCR4 alpha-chemokine receptor and one of its ligands,...

mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients). CXCR4 mutations cause symptomatic hyperviscosity syndrome and high...

caused by a gain-of-function mutation of the chemokine receptor CXCR4. The mutation in CXCR4 increases signaling because it disrupts negative regulatory elements...

Mohammed; et al. (31 August 2022). "Mavorixafor, an Orally Bioavailable CXCR4 Antagonist, Increases Immune Cell Infiltration and Inflammatory Status of...

the surface of CD4+ cells and macrophages, called a chemokine co-receptor CXCR4, another chemokine co-receptor found on CD4+ cells gp41, an HIV protein...

(against CXCL10) CXCR4 Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4) CXCR5 Agonists:...

the expression of CD20 (target of rituximab/ofatumumab) by targeting the CXCR4/SDF1 axis. Together, these data are consistent with a mechanistic model...

myelokathexis. A gain-of-function mutation resulting in a truncated form of CXCR4 is believed to be its cause. The truncated form of the receptor has a 2-fold...

is 25–30%. Retrospective research showed that two chemokine receptors, CXCR4 and CXCR7, can be used as molecular prognosis factors. People who express...

Zhang L, Qiao A, Watson K, Zhang J, Fan GH (February 2008). "Activation of CXCR4 triggers ubiquitination and down-regulation of major histocompatibility...

processes (including vascular endothelial growth factor receptors type 1 and 2, CXCR4, and Tie-2) as well as evidence that the "intermediate" subset is specifically...

Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J (2015). "CXCR4(+)CD45(-) BMMNC subpopulation is superior to unfractionated BMMNCs for protection...

only recently coming to light. It may be mediated by interaction through CXCR4 (CD184) the receptor for CXC Chemokines (e.g., SDF1) and α4β1 integrins...

mice and protected against systemic platelet activation and thrombosis. A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells. A PAR1 pepducin...

famous and well-studied of the CCR family is CCR5 (and its near-homologue CXCR4) which acts as the primary co-receptor for HIV viral infection. The HIV...

(against CXCL10) CXCR4 Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4) CXCR5 Agonists:...

along with the CD4-gp120 complex to enter the target cells - either CCR5 or CXCR4. This demonstrates an example of how cell surface receptors can affect the...

downstream from NF-κB activation leading to decreased chemokine receptor CXCR4 signaling causing reduced inflammation. Despite the efficiency of treating...

activated target CXCR4 gene in K562 cell lines. Comparing with the dCas9-VP64 activation complex, they were able to increase the CXCR4 gene expression...

expressed on the host cell. These co-receptors are chemokine receptors CCR5 or CXCR4. Following a structural change in another viral protein (gp41), HIV inserts...

targets for drug therapy, one of them being the viral entry pathway. CCR5 and CXCR4 are the main receptors involved in the HIV entry process. These receptors...

relationship between HHV-7 and HIV-1 co-receptors CXCR4 and CCR5. During infection, HHV-7 causes a loss of CXCR4 in CD4+ T-cells in addition to lowering intracellular...