Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the...
18 KB (2,214 words) - 03:52, 18 August 2024
chaperone, calnexin, performs the same service for soluble proteins as does calreticulin, however it is a membrane-bound protein. Both proteins, calnexin and...
20 KB (2,452 words) - 02:06, 10 March 2024
loading complex consisting of TAP, tapasin, calreticulin, calnexin, and Erp57 (PDIA3). Calnexin acts to stabilize the class I MHC α chains prior to β2m...
21 KB (2,610 words) - 08:24, 9 August 2024
Rhodes Scholar (Class of 1966). He is best known for the discovery of calnexin, endosomal signalling and organellar proteomics. Bergeron was born in Belleville...
11 KB (1,182 words) - 20:42, 15 October 2024
protein disulfide isomerase (PDI), ERp29, the Hsp70 family member BiP/Grp78, calnexin, calreticulin, and the peptidylprolyl isomerase family. Only properly folded...
34 KB (3,710 words) - 22:16, 7 October 2024
glycoprotein can't leave the endoplasmic reticulum. A chaperone protein (calnexin/calreticulin) binds to the unfolded or partially folded protein to assist...
25 KB (2,510 words) - 20:41, 27 September 2024
which therapies might be beneficial. Lp(a) has been shown to interact with calnexin, fibronectin, and fibrinogen beta chain. Lipoprotein Apolipoprotein Very-low-density...
44 KB (5,339 words) - 10:39, 24 September 2024
(ER). Also within the rough ER, a series of chaperone proteins, including calnexin, calreticulin, ERp57, and Binding immunoglobulin protein (BiP) facilitates...
12 KB (1,763 words) - 18:48, 6 April 2023
ligand for the lectin molecules calreticulin (CRT; soluble in ER lumen) and calnexin (CNX; membrane bound). Favoured by the highly oxidizing environment of...
31 KB (3,592 words) - 16:12, 20 October 2024
A molecular chaperone protein called calnexin and an enzyme called ERp57 assist in the folding process. Calnexin holds the HLA-A heavy chain while Erp57...
27 KB (3,411 words) - 01:57, 10 March 2024
folding. General chaperones: GRP78/BiP, GRP94, GRP170. Lectin chaperones: calnexin and calreticulin Non-classical molecular chaperones: HSP47 and ERp29 Folding...
29 KB (3,499 words) - 07:16, 20 February 2024
involved in hormone and drug action Affect folding of certain proteins Calnexin, calreticulin Regulation of development Notch and its analogs, key proteins...
28 KB (2,653 words) - 04:14, 23 July 2024
an N terminus-linked sugar and co-localized with the chaperone protein calnexin in the ER. After the protein is transported to the Golgi apparatus it can...
12 KB (1,472 words) - 20:31, 4 August 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
37 KB (4,221 words) - 08:11, 28 August 2024
mechanism. There are several ER chaperones involved in MHC-I assembly, such as calnexin, calreticulin, Erp57, protein disulfide isomerase (PDI), and tapasin. Specifically...
14 KB (1,672 words) - 15:05, 12 October 2024
eukaryotic cells. Chaperone proteins in the endoplasmic reticulum, such as calnexin and calreticulin, bind to the three glucose residues present on the core...
26 KB (3,161 words) - 19:09, 8 June 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
19 KB (2,056 words) - 16:29, 7 September 2024
called glycan processing. In this mechanism, the lectin-type chaperones calnexin/calreticulin (CNX/CRT) provide immature glycoproteins the opportunity to...
13 KB (1,709 words) - 07:49, 27 July 2024
family of calcium-binding proteins. This family includes calreticulin, calnexin and camlegin. Michalak M, Milner RE, Burns K, Opas M (August 1992). "Calreticulin"...
2 KB (145 words) - 07:02, 16 July 2024
endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is thought...
10 KB (1,267 words) - 12:58, 8 April 2024
degradation. Study of the changes in glycosylation of the GalNAc-T substrate Calnexin-ERp57 has revealed a novel ECM degradative function for this oxidoreductase...
6 KB (688 words) - 00:51, 11 August 2024
isomerase F PPIG Peptidyl-prolyl cis-trans isomerase G PPIH Cyclophilin H CANX Calnexin. Folding of glycoproteins within endoplasmic reticulum CAPN1 Calpain subunit...
48 KB (4,612 words) - 23:41, 12 December 2023
J. M. Bergeron, cell biologist and biochemist, known for discovery of calnexin, endosomal signalling and organellar proteomics Charles Philippe Leblond...
37 KB (4,535 words) - 22:28, 13 October 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
13 KB (1,645 words) - 00:29, 11 March 2024
specific glycosidases. This process is vital since the lectin chaperones calnexin and calreticulin, involved in protein quality, bind to the Glc1Man9GlcNAc-structure...
41 KB (3,740 words) - 18:14, 25 September 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
9 KB (1,004 words) - 01:36, 11 February 2023
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
12 KB (1,164 words) - 20:59, 17 January 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
21 KB (2,355 words) - 13:40, 24 June 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
19 KB (2,271 words) - 18:47, 25 March 2024
S100P Troponin C TNNC1 TNNC2 Calcium-dependent chaperones Calreticulin Calnexin HSPA5 HSP90B1 Calcium-dependent kinases CaM kinases CAMK1 CAMK2 A B D G...
4 KB (346 words) - 18:37, 31 August 2023