CRISPR systems are characterized by Cas13, a single effector protein that targets RNA. Like the type-V system, Cas13 can process the pre-crRNA without tracrRNA...
10 KB (1,149 words) - 06:02, 17 June 2024
to make new viruses. HIV and poliovirus are such viruses. Bacteria with Cas13 make molecules that can dismember RNA, destroying the virus. Tailoring these...
170 KB (19,897 words) - 15:07, 10 October 2024
CRISPR-Cas variants: Anti-CRISPR - CIRTS - CRISPeY CRISPR-Cas10 - CRISPR-Cas13 - CRISPR-BEST CRISPR-Disp - CRISPR-Gold - CRISPRa - CRISPRi Easi-CRISPR...
22 KB (2,739 words) - 07:27, 29 September 2024
treatment. Viruses portal Antiretroviral drug (especially HAART for HIV) CRISPR-Cas13 Discovery and development of CCR5 receptor antagonists (for HIV) Monoclonal...
55 KB (6,733 words) - 16:37, 17 October 2024
discovered Cas13 with Harvard colleague Eugene Koonin using computational biology methods. In 2016, Zhang cofounded Arbor Biotechnologies to develop Cas13 for...
24 KB (2,097 words) - 04:47, 19 October 2024
CRISPR-Cas variants: Anti-CRISPR - CIRTS - CRISPeY CRISPR-Cas10 - CRISPR-Cas13 - CRISPR-BEST CRISPR-Disp - CRISPR-Gold - CRISPRa - CRISPRi Easi-CRISPR...
24 KB (2,898 words) - 12:08, 22 March 2024
CRISPR-Cas variants: Anti-CRISPR - CIRTS - CRISPeY CRISPR-Cas10 - CRISPR-Cas13 - CRISPR-BEST CRISPR-Disp - CRISPR-Gold - CRISPRa - CRISPRi Easi-CRISPR...
13 KB (1,530 words) - 21:01, 18 August 2024
CRISPR-Cas13. The company was founded in 2019 by Feng Zhang, Jim Collins, Omar Abudayyeh, and Jonathan Gootenberg of the Broad Institute. Cas13 was discovered...
2 KB (202 words) - 13:46, 16 March 2024
2021. Hadidi A (January 2019). "Next-Generation Sequencing and CRISPR/Cas13 Editing in Viroid Research and Molecular Diagnostics". Viruses. 11 (2):...
34 KB (3,907 words) - 11:05, 30 September 2024
guide RNA design to target RNA. They used their model to predict optimized Cas13 guide RNAs for all protein-coding RNA-transcripts of the human genome's...
280 KB (24,498 words) - 09:15, 5 October 2024
CRISPR-Cas variants: Anti-CRISPR - CIRTS - CRISPeY CRISPR-Cas10 - CRISPR-Cas13 - CRISPR-BEST CRISPR-Disp - CRISPR-Gold - CRISPRa - CRISPRi Easi-CRISPR...
32 KB (3,691 words) - 06:48, 24 August 2024
deaminase to correct a mutated cystic fibrosis sequence. More recently, CRISPR-Cas13 fused to deaminases has been employed to direct mRNA editing. In 2022, therapeutic...
61 KB (7,435 words) - 21:16, 25 September 2024
CRISPR-Cas variants: Anti-CRISPR - CIRTS - CRISPeY CRISPR-Cas10 - CRISPR-Cas13 - CRISPR-BEST CRISPR-Disp - CRISPR-Gold - CRISPRa - CRISPRi Easi-CRISPR...
16 KB (2,133 words) - 12:04, 22 March 2024
; Joung, Julia; Zhang, Feng (25 October 2017). "RNA editing with CRISPR-Cas13". Science. 358 (6366): 1019–1027. Bibcode:2017Sci...358.1019C. doi:10.1126/science...
199 KB (18,510 words) - 20:03, 25 August 2024
guide RNA design to target RNA. They used their model to predict optimized Cas13 guide RNAs for all protein-coding RNA-transcripts of the human genome's...
152 KB (15,967 words) - 06:50, 19 October 2024
Kellner MJ, Joung J, Zhang F (November 2017). "RNA editing with CRISPR-Cas13". Science. 358 (6366): 1019–1027. Bibcode:2017Sci...358.1019C. doi:10.1126/science...
53 KB (6,846 words) - 19:05, 8 July 2024
editing tool better suited for therapeutic (temporary) RNA editing than Cas13 is reported, Cas7-11, – of which an early version was used for in vitro...
542 KB (49,157 words) - 06:20, 12 October 2024
guide RNA design to target RNA. They used their model to predict optimized Cas13 guide RNAs for all protein-coding RNA-transcripts of the human genome's...
202 KB (20,060 words) - 20:43, 19 September 2024