Dabrafenib, sold under the brand name Tafinlar among others, is an anti-cancer medication used for the treatment of cancers associated with a mutated version...

with the BRAF inhibitor dabrafenib. As a result of this research, on 8 January 2014, the FDA approved the combination of dabrafenib and trametinib for the...

pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. Important prognosis factors for nodular...

study reported that combining Dabrafenib with a MEK inhibitor trametinib led to even better outcomes. Compared to Dabrafenib alone, progression-free survival...

Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib. It can be treated with urea-containing creams, which dissolve the intercellular...

LHRH, Phase II results for ovarian cancer. Braf inhibitors (vemurafenib, dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF V600E mutation...

Drug Trade name Rac Reference Dabrafenib Tafinlar 0.73 Rosuvastatin Crestor 1.37 in hemodialysis patients Lisinopril Prinivil and others 1.38 Ivacaftor...

pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. When arising in the nailbed of a digit...

keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. Keratoacanthomas presents as a fleshy, elevated and nodular lesion with...

Cancers with hyperactive BRAF (around 2% of NSCLC) can be treated by dabrafenib combined with the MEK inhibitor trametinib; those with activated ROS1...

BRAF mutations have been developed. Two of these drugs, vemurafenib and dabrafenib, are approved by FDA for treatment of late-stage melanoma. Vemurafenib...

January 2015, trial results compared vemurafenib with the combination of dabrafenib and trametinib for metastatic melanoma. Vemurafenib was approved in the...

Raf inhibitors include SB590885, PLX4720, XL281, RAF265, encorafenib, dabrafenib, and vemurafenib. Some MEK inhibitors include cobimetinib, CI-1040, PD0325901...

pembrolizumab, nivolumab, cemiplimab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. In February 2024, the Food and Drug Administration...

pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and an MEK inhibitor trametinib. Melanoma List of cutaneous conditions...

BRAF-mutated melanoma. Also studied in combination with BRAF inhibitor dabrafenib to treat BRAF-mutated melanoma. PD-325901, for breast cancer, colon cancer...

immunosuppressive), modafinil (stimulant), capsaicin, brigatinib, clobazam, dabrafenib, elagolix, eslicarbazepine, letermovir, lorlatinib, oritavancin, perampanel...

anaplastic thyroid cancer harboring such mutations. The combination of dabrafenib and trametinib has shown significant increases in overall survival and...

(these three drugs are tyrosine kinase inhibitors that may also cause MG), dabrafenib, and trametinib; 3) antipsychotic drugs, i.e., chlorpromazine, pimozide...

V600 are effectively druggable with small molecule inhibitors such as dabrafenib. Unfortunately, drug resistance is observed within 4-6 months after treatment...

De | Df–Di | Do | Dr–Dy D.H.E. 45 dabelotine (INN) dabigatran (USAN) dabrafenib (INN) dabuzalgron (USAN) dacarbazine (INN) dacemazine (INN) dacetuzumab...

basal activity and hence is oncogenic. Vemurafenib, encorafenib, and dabrafenib are approved by the FDA for treatment of metastatic melanomas that express...

L01EB10 Mobocertinib L01EB11 Aumolertinib L01EC01 Vemurafenib L01EC02 Dabrafenib L01EC03 Encorafenib L01ED01 Crizotinib L01ED02 Ceritinib L01ED03 Alectinib...

hypophosphatemia Osimertinib AstraZeneca metastatic non-small cell lung cancer Dabrafenib Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Trametinib...

was approved for medical use in the United States in September 2020. Dabrafenib and trametinib have been approved as tissue-agnostic drugs for solid tumors...

discovered two monotherapy drugs – Mekinist (trametinib) and Tafinlar (dabrafenib) – can be safely combined to overcome or delay treatment resistance for...

Center for Drug Evaluation and Research (2023-03-31). "FDA approves dabrafenib with trametinib for pediatric patients with low-grade glioma with a BRAF...

Several other molecules followed up, such as Vemurafenib, Regorafenib, Dabrafenib, etc. Unfortunately, ATP-competitive B-Raf inhibitors may have an undesired...

associated with driver mutations in kinases. Axitinib, gefitinib, and dabrafenib to are used to treat adult acute lymphoblastic leukemia, non-small-cell...