• Thumbnail for Epidermal growth factor receptor
    factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family)...
    60 KB (6,879 words) - 14:26, 16 July 2024
  • Thumbnail for Epidermal growth factor
    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has 53...
    17 KB (1,708 words) - 22:30, 15 October 2024
  • Thumbnail for Receptor tyrosine kinase
    receptor tyrosine kinases was not developed until the 1970s. Approximately 20 different RTK classes have been identified. RTK class I (EGF receptor family)...
    28 KB (3,078 words) - 07:46, 3 June 2024
  • Thumbnail for Cell surface receptor
    For example, after the epidermal growth factor (EGF) receptor binds with its ligand EGF, the two receptors dimerize and then undergo phosphorylation of the...
    21 KB (2,456 words) - 22:14, 21 November 2023
  • Schlessinger, Joseph (2002). "Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor". Cell. 110 (6): 669–672. doi:10.1016/s0092-8674(02)00966-2...
    24 KB (2,736 words) - 00:12, 28 November 2023
  • epidermal growth factor (EGF). Binding of EGF to the EGFR activates the tyrosine kinase activity of the cytoplasmic domain of the receptor. The EGFR becomes...
    24 KB (3,068 words) - 07:21, 7 June 2024
  • Thumbnail for Heparin-binding EGF-like growth factor
    HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptors effecting cell-to-cell interactions. Heparin-binding EGF-like...
    20 KB (2,598 words) - 14:07, 21 July 2024
  • Thumbnail for Endosome
    proton pump V-ATPase. On the other hand, epidermal growth factor (EGF) and the EGF receptor have a pH-resistant bond that persists until it is delivered to...
    22 KB (2,647 words) - 07:14, 29 May 2024
  • Thumbnail for Lipid raft
    signalling, T cell antigen receptor signalling, B cell antigen receptor signalling, EGF receptor signalling, insulin receptor signalling and so on. In order...
    57 KB (6,661 words) - 09:44, 6 October 2024
  • Panitumumab (redirect from ABX-EGF)
    monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans). Panitumumab is manufactured...
    16 KB (1,421 words) - 15:40, 14 July 2024
  • Thumbnail for Tyrosine kinase inhibitor
    Gazit A, Gilon C, Levitzki A (1988). "Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors". Science. 242 (4880): 933–935. Bibcode:1988Sci...
    10 KB (1,179 words) - 18:31, 8 August 2024
  • Thumbnail for HER2
    HER2 (redirect from ErbB-2 receptor)
    the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". The Journal of Biological Chemistry...
    43 KB (4,651 words) - 13:41, 27 July 2024
  • Thumbnail for Androgen receptor
    Muratori M, Formigli L, Zecchi S, Forti G, et al. (October 2004). "EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen-sensitive...
    87 KB (9,376 words) - 13:18, 19 August 2024
  • Thumbnail for Amivantamab
    bispecific epidermal growth factor (EGF) receptor-directed and mesenchymal–epithelial transition (MET) receptor-directed antibody. It is the first treatment...
    24 KB (1,890 words) - 16:21, 4 October 2024
  • Thumbnail for TGF alpha
    TGF alpha (section Receptor)
    epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide. The protein becomes activated when binding to receptors capable of protein kinase...
    17 KB (2,112 words) - 08:28, 7 September 2024
  • Thumbnail for Ira Pastan
    identified the EGF receptor as a proto-oncogene. Besides being one of the first 3 laboratories to obtain the DNA sequence of the EGF receptor, they showed...
    13 KB (1,810 words) - 23:58, 10 October 2024
  • Thumbnail for VEGF receptor
    VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending...
    8 KB (754 words) - 13:03, 18 September 2024
  • growth factor, or EGF) binds to the receptor (called EGFR). This activates the receptor to phosphorylate itself. The phosphorylated receptor binds to an adaptor...
    62 KB (6,781 words) - 23:57, 21 August 2024
  • The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of...
    8 KB (827 words) - 22:08, 3 December 2023
  • Thumbnail for Protein kinase
    factor family: beyond receptor ligands. Cancer Sci. 2008 Feb;99(2):214-20. Review. PMID: 18271917 Carpenter G. The EGF receptor: a nexus for trafficking...
    15 KB (1,635 words) - 23:25, 13 August 2024
  • the EGF receptor are thwarted by the co-activation of alternate receptor tyrosine kinases (RTK) that have partial functional overlap with the EGF receptor...
    22 KB (2,307 words) - 09:54, 5 October 2024
  • A metabotropic receptor, also referred to by the broader term G-protein-coupled receptor, is a type of membrane receptor that initiates a number of metabolic...
    6 KB (625 words) - 00:59, 6 June 2024
  • Thumbnail for ERBB3
    ERBB3 (redirect from Receptor, erbb-3)
    McGrath J, et al. (December 1985). "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science...
    24 KB (2,816 words) - 23:40, 12 September 2024
  • Murodermin (redirect from RmEGF)
    murine epidermal growth factor (rmEGF), is a recombinant form of mouse epidermal growth factor (EGF) and an EGF receptor agonist which was never marketed...
    6 KB (80 words) - 23:41, 22 January 2023
  • Thumbnail for Tropomyosin receptor kinase B
    Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type...
    40 KB (4,319 words) - 02:54, 11 August 2024
  • Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...
    9 KB (974 words) - 14:46, 22 June 2024
  • Thumbnail for Ommatidium
    S2CID 10924209. Li X, Carthew RW (December 2005). "A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila...
    10 KB (1,224 words) - 14:04, 2 November 2023
  • CimaVax-EGF is a vaccine used to treat cancer, specifically non-small-cell lung carcinoma (NSCLC). CIMAvax-EGF is composed of recombinant human epidermal...
    16 KB (1,556 words) - 23:09, 17 July 2024
  • Thumbnail for Insulin receptor
    The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase...
    31 KB (3,785 words) - 19:26, 2 September 2024
  • Thumbnail for GRB2
    the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". The Journal of Biological Chemistry...
    82 KB (9,365 words) - 15:39, 31 March 2024