factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family)...
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Epidermal growth factor (redirect from EGF (gene))
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has 53...
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receptor tyrosine kinases was not developed until the 1970s. Approximately 20 different RTK classes have been identified. RTK class I (EGF receptor family)...
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For example, after the epidermal growth factor (EGF) receptor binds with its ligand EGF, the two receptors dimerize and then undergo phosphorylation of the...
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ErbB (redirect from Epidermal growth factor receptor family)
Schlessinger, Joseph (2002). "Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor". Cell. 110 (6): 669–672. doi:10.1016/s0092-8674(02)00966-2...
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epidermal growth factor (EGF). Binding of EGF to the EGFR activates the tyrosine kinase activity of the cytoplasmic domain of the receptor. The EGFR becomes...
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HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptors effecting cell-to-cell interactions. Heparin-binding EGF-like...
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proton pump V-ATPase. On the other hand, epidermal growth factor (EGF) and the EGF receptor have a pH-resistant bond that persists until it is delivered to...
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Lipid raft (section T-cell antigen receptor signaling)
signalling, T cell antigen receptor signalling, B cell antigen receptor signalling, EGF receptor signalling, insulin receptor signalling and so on. In order...
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Panitumumab (redirect from ABX-EGF)
monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans). Panitumumab is manufactured...
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Gazit A, Gilon C, Levitzki A (1988). "Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors". Science. 242 (4880): 933–935. Bibcode:1988Sci...
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HER2 (redirect from ErbB-2 receptor)
the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". The Journal of Biological Chemistry...
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Muratori M, Formigli L, Zecchi S, Forti G, et al. (October 2004). "EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen-sensitive...
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bispecific epidermal growth factor (EGF) receptor-directed and mesenchymal–epithelial transition (MET) receptor-directed antibody. It is the first treatment...
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identified the EGF receptor as a proto-oncogene. Besides being one of the first 3 laboratories to obtain the DNA sequence of the EGF receptor, they showed...
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VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending...
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Cell signaling (section Steroid hormone receptor)
growth factor, or EGF) binds to the receptor (called EGFR). This activates the receptor to phosphorylate itself. The phosphorylated receptor binds to an adaptor...
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The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of...
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Protein kinase (section Receptor tyrosine kinases)
factor family: beyond receptor ligands. Cancer Sci. 2008 Feb;99(2):214-20. Review. PMID: 18271917 Carpenter G. The EGF receptor: a nexus for trafficking...
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the EGF receptor are thwarted by the co-activation of alternate receptor tyrosine kinases (RTK) that have partial functional overlap with the EGF receptor...
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A metabotropic receptor, also referred to by the broader term G-protein-coupled receptor, is a type of membrane receptor that initiates a number of metabolic...
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ERBB3 (redirect from Receptor, erbb-3)
McGrath J, et al. (December 1985). "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science...
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Murodermin (redirect from RmEGF)
murine epidermal growth factor (rmEGF), is a recombinant form of mouse epidermal growth factor (EGF) and an EGF receptor agonist which was never marketed...
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Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type...
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Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...
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S2CID 10924209. Li X, Carthew RW (December 2005). "A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila...
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CimaVax-EGF is a vaccine used to treat cancer, specifically non-small-cell lung carcinoma (NSCLC). CIMAvax-EGF is composed of recombinant human epidermal...
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The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase...
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GRB2 (redirect from Growth factor receptor-bound protein 2)
the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". The Journal of Biological Chemistry...
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