translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. Most eukaryotic cellular mRNAs are blocked...

the eIF4E•G•A trimeric complex can be directly purified from cells, while only the two subunit eIF4E•G can be purified from yeast cells. eIF4E binds...

translation initiation factor eIF4E, especially acute myeloid leukemia (AML) as well as in head and neck cancers. Ribavirin targeted eIF4E in AML patients in monotherapy...

metabolism in cancer using the eukaryotic translation initiation factor eIF4E as an exemplar. Her studies demonstrated that dysregulation of this factor...

pioneer round of translation, the CBC is replaced by the translation factors eIF4E and eIF4G of the eIF4F complex. This complex is then recognized by other...

factors: eIF4A, eIF4E, and eIF4G. eIF4G is a scaffolding protein that directly associates with both eIF3 and the other two components. eIF4E is the cap-binding...

4EBP1: eukaryotic translation initiation factor 4E-binding protein 1  • eIF4E: eukaryotic translation initiation factor 4E  • RPS6: ribosomal protein...

subunits. eIF4E BPs (4E-BPs), as small polypeptides, consist of the same amino acid sequence as the portion of eIF4G that interacts with eIF4E. 4EGI-1 thus...

binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation...

expression by recruiting a protein called Cup (an eIF4E-binding protein that blocks the binding of eIF4G to eIF4E). There after it recruits deadenylation complex...

serves to control the quality of gene expression, while the translation of eIF4E-bound mRNAs serves to produce the majority of proteins. However, both of...

are EIF4G2 and EIF4G3.) Across species, eIF4G strongly associates with eIF4E, the protein that directly binds the mRNA cap. Together with the RNA helicase...

chemotherapy. Bcl-2-positive lymphomas were completely resistant to the therapy; eIF4E-expressing lymphomas are not sensitive to sirolimus. Sirolimus also shows...

cap-binding protein, eIF4E, the rate-limiting component of the eukaryotic translation apparatus, and also discovered the regulation of eIF4E by the eIF4EBPs...

experimental airliner developed before World War II E4 (disambiguation) eIF4E, Eukaryotic translation initiation factor 4E, a protein This disambiguation...

mRNA molecules form circular structures due to an interaction between the eIF4E and poly(A)-binding protein, which both bind to eIF4G, forming an mRNA-protein-mRNA...

CBC20/80 is replaced by the translation initiation factor eIF4E. The eIF4F complex (eIF4E, eIF4G and eIF4A) then regulates translation in response to...

5′ cap, which in turn recruits the ribosomal complex to the 5′ UTR. Both eIF4E and eIF4G bind the 5′ UTR, which limits the rate at which translational...

frame for the EIF4EBP3 segments. EIF4EBP3 has been shown to interact with EIF4E. GRCh38: Ensembl release 89: ENSG00000243056 – Ensembl, May 2017 GRCm38:...

factors, including the 'translational elongation initiation factor 4E' (eIF4E) complex, which binds to and caps the 5' end of mRNAs. The protein TOR,...

et al. (May 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". The Journal of Biological Chemistry. 273 (21):...

eIF-4E seems to be implicated in cap-binding. Members of this family include EIF4E, EIF4E2, EIF4E3 and EIF4E1B. Thach RE (January 1992). "Cap recap: the involvement...

thereby releasing it from eukaryotic translation initiation factor 4E (eIF4E). eIF4E is now free to join the eukaryotic translation initiation factor 4G...

4EBP1: eukaryotic translation initiation factor 4E-binding protein 1  • eIF4E: eukaryotic translation initiation factor 4E  • RPS6: ribosomal protein...

whole complex made up of eIF4A, eIF4B, eIF4E, and eIF4G. eIF4F is used to refer to the complex that comprises eIF4E, 4G, and 4A. In cap-dependent translation...

functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation factor 4E (eIF4E). For eIF2B-epsilon, the W2 C-terminal...

remain together, then maskin binds the initiation factor eIF-4E, and thus eIF4E can no longer interact with the other initiation factors and no translation...

formed by free polyadenylated mRNA in the presence of initiation factor eIF4E bound to the 5’ cap and PABP bound to the 3’-poly(A) tail. However, this...

Poliovirus is also involved in the cleavage of eIF4E (Eukaryotic translation initiation factor 4E). eIF4E is a protein involved in directing Eukaryotic...

translational regulation. The eIF4F complex is composed of three subunits: eIF4A, eIF4E, and eIF4G. Each subunit has multiple human isoforms and there exist additional...