Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. It was discovered by Professors Tun-Hou Lee and Myron...
21 KB (2,547 words) - 00:52, 4 December 2023
involves the high-affinity attachment of the CD4 binding domains of gp120 to CD4. Once gp120 is bound with the CD4 protein, the envelope complex undergoes a...
125 KB (14,362 words) - 01:15, 28 July 2024
through its viral envelope protein known as gp120. The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor...
22 KB (2,581 words) - 20:03, 21 June 2024
Env (gene) (section gp120)
homotrimer, and is cleaved into gp120 and gp41 by the host cell protease, furin. To form an active fusion protein, SU gp120 and TM gp41 polypeptides remain...
17 KB (2,253 words) - 14:23, 3 December 2023
can bind, through the gp120 and gp41 proteins on its surface. HIV also requires a second co-receptor along with the CD4-gp120 complex to enter the target...
21 KB (2,537 words) - 07:13, 13 August 2024
of the escape pathways can be utilized to design immunogens. The region gp120 of HIV-1 Env which contacts CD4, its primary receptor, is functionally conserved...
25 KB (3,270 words) - 05:30, 15 April 2024
other viruses. Furthermore, the functionally important epitopes of the gp120 protein are masked by glycosylation, trimerisation and receptor-induced...
48 KB (5,619 words) - 18:37, 13 August 2024
gp120 to the CD4 receptor A conformational change in gp120, which both increases its affinity for a co-receptor and exposes gp41 The binding of gp120...
9 KB (1,095 words) - 03:47, 25 December 2023
envelope glycoprotein (Env) of HIV, a trimer formed by heterodimers of gp120 and gp41. Env is responsible for binding to its primary host receptor, CD4...
33 KB (3,936 words) - 19:54, 3 July 2024
on the surface of the virion and consists of a trimer of Gp120-Gp41 hetero-dimers. The Gp120 envelope protein is a chemokine mimic. Though it lacks the...
67 KB (7,845 words) - 11:20, 5 August 2024
et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507...
31 KB (2,293 words) - 12:25, 28 December 2023
molecule, which induces a change in the conformation of gp120. This change in conformation allows the gp120 complex to interact with the chemokine co-receptor...
45 KB (5,620 words) - 14:28, 22 March 2024
Auffray C (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–128. doi:10.1007/BF00211424. PMID 1869305...
10 KB (1,251 words) - 06:48, 11 July 2024
CCR5 antagonist, a CD4 T lymphocyte (CD4) post-attachment inhibitor, and a gp120 attachment inhibitor. There are also two drugs, ritonavir (RTV) and cobicistat...
206 KB (21,194 words) - 02:57, 13 August 2024
gp120 libraries led to one that strongly bound both an original antibody and the mature bNAb that evolved from it. Giving patients a modified gp120 that...
8 KB (870 words) - 20:43, 3 July 2024
Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929...
16 KB (1,905 words) - 14:50, 13 August 2024
much attention as a potential target for HIV vaccines. Gp41 is coded with gp120 as one gp160 by the env gene of HIV. Gp160 is then extensively glycosylated...
14 KB (1,709 words) - 03:20, 12 March 2024
et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507...
11 KB (1,225 words) - 15:04, 12 August 2023
limited range of human leucocytes. This is because its surface protein, gp120, specifically interacts with the CD4 molecule—a chemokine receptor—which...
155 KB (18,249 words) - 17:17, 17 July 2024
an HLA-B serotype IgG1-b12, an antibody against the HIV surface protein gp120 found in some long-term nonprogressors 12B (disambiguation) This disambiguation...
1 KB (241 words) - 21:37, 10 November 2023
clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor...
14 KB (1,377 words) - 05:34, 21 January 2024
replication throughout the body. HIV can enter the macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both circulating...
92 KB (10,131 words) - 14:06, 1 July 2024
cells. While natural anti-gp120 antibodies exhibit a response towards uninfected CD4-expressing cells that have a soluble gp120 bound to the CD4 on the...
23 KB (2,878 words) - 15:39, 12 April 2024
the primate lentiviruses).[which?] Structural proteins listed by size: Gp120 surface envelope protein SU, encoded by the viral gene env. 120000 Da (daltons)...
16 KB (1,770 words) - 21:42, 20 July 2024
1999). "Evidence for a synergistic effect of the HIV-1 envelope protein gp120 and brain-derived neurotrophic factor (BDNF) leading to enhanced expression...
23 KB (2,532 words) - 08:06, 21 July 2024
CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proceedings of the National Academy of Sciences. 89 (17): 8356–60. Bibcode:1992PNAS...
31 KB (3,348 words) - 04:56, 15 July 2024
Human Immunodeficiency Virus(HIV) (most commonly on the envelope protein gp120) that elicits antibodies with neutralizing activity. V3 loop Human Immunodeficiency...
985 bytes (87 words) - 19:00, 20 January 2021
Immunodeficiency Virus Type 1 Attachment to HeLa CD4 Cells Is CD4 Independent and gp120 Dependent and Requires Cell Surface Heparans". Journal of Virology. 72 (5):...
48 KB (5,642 words) - 15:16, 17 July 2024
expression. HIV protein gp120 inhibits the stem cells in the brain from producing new nerve cells. In the neuronal cells, the HIV gp120 induces mitochondrial-death...
32 KB (3,822 words) - 07:02, 15 April 2024
Vicriviroc†, Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA), Semzuvolimab§) gp120 (Fostemsavir (FTR)) Integrase inhibitors (Integrase strand transfer inhibitors...
15 KB (1,230 words) - 02:38, 16 July 2024