Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial...
32 KB (3,791 words) - 18:56, 19 August 2024
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid...
5 KB (486 words) - 01:52, 12 August 2023
musculature and muscle weakness, growth delay, exercise intolerance, cardiolipin abnormalities, and 3-methylglutaconic aciduria. It can be associated...
16 KB (1,717 words) - 18:21, 30 October 2024
phospholipid:diacylglycerol acyltransferases). It catalyzes remodeling of immature cardiolipin to its mature composition containing a predominance of tetralinoleoyl...
58 KB (6,767 words) - 09:34, 6 October 2024
with anti-mitochondrial antibodies have been identified. M1 – cardiolipin (Anti-cardiolipin antibodies, ACA) M2 – branched-chain alpha-keto acid dehydrogenase...
5 KB (500 words) - 10:03, 21 October 2023
against substances released by cells when they are damaged by T. pallidum (cardiolipin and lecithin). Traditionally, syphilis serologic testing has been performed...
6 KB (532 words) - 18:27, 1 November 2024
extract of ox heart (diphosphatidyl glycerol). It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test...
6 KB (670 words) - 04:09, 16 January 2025
to cardiolipin by reacting with a molecule of cytidine diphosphate diglyceride in a reaction catalyzed by cardiolipin synthase. Glycerol Cardiolipin Lipid-gated...
5 KB (622 words) - 17:17, 9 October 2024
after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2. It can also work to restore cardiolipin levels in the inner mitochondrial...
19 KB (1,857 words) - 09:46, 12 December 2024
detect lupus anticoagulant, anti-apolipoprotein antibodies, and/or anti-cardiolipin antibodies. Antiphospholipid syndrome can be primary or secondary. •...
39 KB (4,116 words) - 18:56, 3 January 2025
MTP did indeed have cardiolipin remodeling capabilities. This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation...
6 KB (589 words) - 15:55, 17 May 2024
mitochondria and chloroplasts, and also bacterial cell membranes; and that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell...
69 KB (7,433 words) - 11:47, 31 December 2024
reduce the production of toxic reactive oxygen species and stabilize cardiolipin. Stealth Peptides, a privately held company, was founded in 2006 to develop...
5 KB (208 words) - 04:15, 3 April 2023
mitochondrial ROS production is stimulated, and cardiolipin is oxidized by a peroxidase function of the cardiolipin–cytochrome c complex. The hemoprotein is...
31 KB (3,827 words) - 19:46, 28 November 2024
biosynthesis of cardiolipin in mitochondria, and its overexpression in cultured cells resulted in increased cardiolipin synthase activity. As cardiolipin is synthesized...
16 KB (1,688 words) - 00:01, 8 June 2024
Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered in cow hearts in 1942, and...
163 KB (18,094 words) - 01:55, 1 February 2025
generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e....
16 KB (1,863 words) - 05:25, 4 December 2024
erythematosus but often detected in people without the disease), anti-cardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies; it is therefore regarded...
47 KB (5,588 words) - 07:21, 4 December 2024
the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure...
12 KB (1,419 words) - 19:08, 13 August 2023
anticoagulant-positive". Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis. SLE may...
136 KB (14,842 words) - 13:54, 29 January 2025
acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861–31870. doi:10...
93 KB (10,764 words) - 12:03, 22 January 2025
can make the tolerance of bacteria. The second one is the increase of cardiolipin abundance in the membrane.The serum-adapted bacteria can change their...
118 KB (13,079 words) - 08:03, 6 January 2025
antibodies. The two antibodies implicated are anti-cardiolipin and lupus anticoagulant. Anti-cardiolipin antibodies attach to the endothelial lining of cells...
8 KB (923 words) - 20:04, 17 December 2024
monolysocardiolipin (MLCL) into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which was then...
6 KB (635 words) - 17:47, 7 July 2024
of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present...
2 KB (106 words) - 15:22, 26 August 2023
ATP synthases, but the FO subcomplex has many unique subunits. It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida...
34 KB (3,778 words) - 13:04, 21 January 2025
phospholipid composition. Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria,...
9 KB (908 words) - 22:11, 10 November 2024
Sodium oxide (NaO) Nonyl Acridine Orange, a fluorescent die. It can stain cardiolipin content of mitochondria. North Atlantic oscillation, a climatic phenomenon...
1 KB (218 words) - 20:16, 7 October 2023
blood or cerebrospinal fluid is taken and introduced to the antigen – cardiolipin extracted from bovine muscle or heart. Syphilis non-specific antibodies...
6 KB (483 words) - 15:10, 24 January 2024
homodimer. This is required for activity. Dimers are connected by a cardiolipin molecule, which has been found to play a key role in stabilization of...
36 KB (3,590 words) - 04:40, 13 January 2025