minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative...

72 polymorphisms, MDM2 SNP309, and A2164G may collectively be associated with non-oropharyngeal cancer susceptibility and that MDM2 SNP309 in combination...

unlike most neoplastic cell in the liposarcomas, do not overexpress the MDM2 gene); 2) atypical spindle cell lipomas (i.e. benign tumors with mildly atypical...

can regulate cytosolic protein localization. For example, the E3 ligase MDM2 ubiquitylates p53 either for degradation (K48 polyubiquitin chain), or for...

accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting...

SWI/SNF complex assembly pathway. The protein domain, SWIB/MDM2, short for SWI/SNF complex B/MDM2 is an important domain. This protein domain has been found...

Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical...

Spongotine B Cis-imidazolines act as small-molecule antagonists of MDM2. These compounds bind MDM2/X in the p53-binding pocket and activate the p53 pathway in...

Brigimadlin (BI-907828) is a small molecule MDM2-TP53 inhibitor developed for liposarcoma. "Brigimadlin". pubchem.ncbi.nlm.nih.gov. Rinnenthal, Joerg;...

tumor cases, including of MDM2, a gene encodes for a RING E3 Ubiquitin ligase responsible for downregulation of p53 activity. MDM2 targets p53 for ubiquitylation...

the tumor suppressor protein p53, as it can interact with and sequester MDM2, a protein responsible for the degradation of p53. In spite of their structural...

Journal of medicinal chemistry, 2003 Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth...

metal band My Dear Melancholy, an extended play by the Weeknd Mdm2 protein, encoded by the MDM2 gene in humans Medical decision-making, part of differential...

cancer HRAS 30% KRAS 20% MYB 15–20% Esophageal cancer MYC 40% CCND1 25% MDM2 13% Gastric cancer CCNE (Cyclin E) 15% KRAS 10% MET 10% Glioblastoma ERBB1...

L6 M N O Q1 Q2 R1 (CDC34) R2 S V1 V2 Z E3 Ubiquitin ligase VHL Cullin CBL MDM2 FANCL UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like...

significant structural similarity to p53-binding protein MDM2 MDM4 has been shown to interact with E2F1, Mdm2 and P53. GRCh38: Ensembl release 89: ENSG00000198625...

N-terminal domain of p53, a tumor suppressor protein. As such, it binds to MDM2 and MDMX, leading to tumor cell apoptosis. Sulanemadlin is notable as the...

activating Mdm2, the signal transduction pathway will trigger the anti-apoptotic downstream effects of Mdm2. With no p14ARF to regulate and inhibit Mdm2, there...

released a single strand DNA molecule (ssDNA) that is an antisense for MDM2. MDM2 is a repressor of protein 53, which itself is a tumor suppressor. On negative...

number of drug discovery labs using various E3 ligases, including pVHL, CRBN, Mdm2, beta-TrCP1, DCAF15, DCAF16, RNF114, and c-IAP1. Yale University licensed...

the genome.[citation needed] RPL11 has been shown to interact with: BLMH, Mdm2, NOP53, P16, P53, and Promyelocytic leukemia protein GRCh38: Ensembl release...

stories include the MDM2 motif analog Nutlin-3 and integrin targeting RGD-mimetic Cilengitide: Nutlin-3 antagonises the interaction of MDM2's SWIB domain with...

and directs the degradation of MDM2, which is dependent on phosphorylation of MDM2 by ATM. FBXO31-mediated loss of MDM2 leads to elevated levels of p53...

of known cancer-promoting genes ("oncogenes") such as the CDK4 gene, the MDM2 gene and the HMGA2 gene. Diagnosis of bone sarcomas begins with a thorough...

Targets of this post-translational regulatory mechanism include VHL, PML, MDM2, POLD1, RelA, HAND1 and hTERT, among many others. It is now known that long...

red-haired people have a mutated copy.[citation needed] Mutation of the MDM2 SNP309 gene is associated with increased risks for younger women. Fair- and...

blocking growth and survival signaling further upstream. Finally, adding p53-MDM2 complexes displaces p53 and activates the p53 pathway, leading to cell cycle...

homologous recombination or radiation-induced gene activation of p21 or Mdm2". J. Cell. Biochem. 91 (5): 987–98. doi:10.1002/jcb.20003. PMID 15034933...

Peng R, Zhang H (September 2018). "Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic...

Previous work had shown that the feedback loop between p53 and its regulator Mdm2 could theoretically cause oscillations in the level of p53. Oscillations...