minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative...
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72 polymorphisms, MDM2 SNP309, and A2164G may collectively be associated with non-oropharyngeal cancer susceptibility and that MDM2 SNP309 in combination...
124 KB (13,220 words) - 11:01, 30 August 2024
unlike most neoplastic cell in the liposarcomas, do not overexpress the MDM2 gene); 2) atypical spindle cell lipomas (i.e. benign tumors with mildly atypical...
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can regulate cytosolic protein localization. For example, the E3 ligase MDM2 ubiquitylates p53 either for degradation (K48 polyubiquitin chain), or for...
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accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting...
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SWI/SNF (section SWIB/MDM2 protein domain)
SWI/SNF complex assembly pathway. The protein domain, SWIB/MDM2, short for SWI/SNF complex B/MDM2 is an important domain. This protein domain has been found...
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Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical...
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Spongotine B Cis-imidazolines act as small-molecule antagonists of MDM2. These compounds bind MDM2/X in the p53-binding pocket and activate the p53 pathway in...
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Brigimadlin (BI-907828) is a small molecule MDM2-TP53 inhibitor developed for liposarcoma. "Brigimadlin". pubchem.ncbi.nlm.nih.gov. Rinnenthal, Joerg;...
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tumor cases, including of MDM2, a gene encodes for a RING E3 Ubiquitin ligase responsible for downregulation of p53 activity. MDM2 targets p53 for ubiquitylation...
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the tumor suppressor protein p53, as it can interact with and sequester MDM2, a protein responsible for the degradation of p53. In spite of their structural...
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Journal of medicinal chemistry, 2003 Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth...
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metal band My Dear Melancholy, an extended play by the Weeknd Mdm2 protein, encoded by the MDM2 gene in humans Medical decision-making, part of differential...
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cancer HRAS 30% KRAS 20% MYB 15–20% Esophageal cancer MYC 40% CCND1 25% MDM2 13% Gastric cancer CCNE (Cyclin E) 15% KRAS 10% MET 10% Glioblastoma ERBB1...
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L6 M N O Q1 Q2 R1 (CDC34) R2 S V1 V2 Z E3 Ubiquitin ligase VHL Cullin CBL MDM2 FANCL UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like...
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significant structural similarity to p53-binding protein MDM2 MDM4 has been shown to interact with E2F1, Mdm2 and P53. GRCh38: Ensembl release 89: ENSG00000198625...
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N-terminal domain of p53, a tumor suppressor protein. As such, it binds to MDM2 and MDMX, leading to tumor cell apoptosis. Sulanemadlin is notable as the...
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activating Mdm2, the signal transduction pathway will trigger the anti-apoptotic downstream effects of Mdm2. With no p14ARF to regulate and inhibit Mdm2, there...
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released a single strand DNA molecule (ssDNA) that is an antisense for MDM2. MDM2 is a repressor of protein 53, which itself is a tumor suppressor. On negative...
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number of drug discovery labs using various E3 ligases, including pVHL, CRBN, Mdm2, beta-TrCP1, DCAF15, DCAF16, RNF114, and c-IAP1. Yale University licensed...
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the genome.[citation needed] RPL11 has been shown to interact with: BLMH, Mdm2, NOP53, P16, P53, and Promyelocytic leukemia protein GRCh38: Ensembl release...
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stories include the MDM2 motif analog Nutlin-3 and integrin targeting RGD-mimetic Cilengitide: Nutlin-3 antagonises the interaction of MDM2's SWIB domain with...
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and directs the degradation of MDM2, which is dependent on phosphorylation of MDM2 by ATM. FBXO31-mediated loss of MDM2 leads to elevated levels of p53...
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of known cancer-promoting genes ("oncogenes") such as the CDK4 gene, the MDM2 gene and the HMGA2 gene. Diagnosis of bone sarcomas begins with a thorough...
37 KB (4,087 words) - 23:54, 14 August 2024
Targets of this post-translational regulatory mechanism include VHL, PML, MDM2, POLD1, RelA, HAND1 and hTERT, among many others. It is now known that long...
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red-haired people have a mutated copy.[citation needed] Mutation of the MDM2 SNP309 gene is associated with increased risks for younger women. Fair- and...
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blocking growth and survival signaling further upstream. Finally, adding p53-MDM2 complexes displaces p53 and activates the p53 pathway, leading to cell cycle...
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homologous recombination or radiation-induced gene activation of p21 or Mdm2". J. Cell. Biochem. 91 (5): 987–98. doi:10.1002/jcb.20003. PMID 15034933...
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Peng R, Zhang H (September 2018). "Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic...
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Previous work had shown that the feedback loop between p53 and its regulator Mdm2 could theoretically cause oscillations in the level of p53. Oscillations...
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