Hepatitis C virus nonstructural protein 4A (redirect from NS4A)
Nonstructural protein 4A (NS4A) is a viral protein found in the hepatitis C virus. It acts as a cofactor for the enzyme NS3. Beld M, Penning M, van Putten...
753 bytes (76 words) - 04:20, 16 July 2023
Dengue virus (section NS4A protein)
structural (C, E, prM) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5). All non-structural proteins are necessary to together create...
60 KB (7,196 words) - 04:25, 19 October 2024
[citation needed] Nonstructural proteins consist of NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. These proteins mainly assist with viral replication or act...
41 KB (4,959 words) - 16:39, 7 October 2024
dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular...
2 KB (186 words) - 02:47, 27 September 2024
forms a heterodimeric complex with NS4A—a 54 amino acid membrane protein that acts as a cofactor of the proteinase. NS4A—a 54 amino acid membrane protein...
54 KB (6,612 words) - 08:16, 2 November 2024
Glecaprevir/pibrentasvir Combination of Glecaprevir NS3/NS4A inhibitor Pibrentasvir NS5A inhibitor Clinical data Trade names Mavyret, Maviret, others AHFS/Drugs...
10 KB (870 words) - 03:38, 14 April 2024
responsible for viral replication and include the following three classes: NS3 and NS4A protease inhibitors, including telaprevir, boceprevir, simeprevir, and others...
165 KB (16,882 words) - 20:39, 31 October 2024
antigens have been found in infected cell nuclei. The viral protein numbered NS4A can lead to small head size (microcephaly) because it disrupts brain growth...
74 KB (7,597 words) - 16:49, 2 November 2024
infection. A complex known as NS2-NS3/NS4A (NS2-3/4A) is created when NS4A joins with uncleaved NS2-NS3 (NS2-3) or NS3/NS4A. It can be utilized to support RNA...
32 KB (3,949 words) - 15:39, 12 October 2024
protein (E). The seven nonstructural proteins are: NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. The role of some nonstructural proteins is known, NS5 serves...
23 KB (2,724 words) - 17:35, 6 August 2024
two viral proteins found in hepatitis C virus: NS4A NS4B Dengue virus NS4a and NS4b West Nile virus NS4A and NS4B New Shepard 4, a Blue Origin reusable...
1 KB (203 words) - 18:44, 1 December 2023
structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein...
111 KB (12,219 words) - 16:27, 2 November 2024
and Envelope) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5). The genomic RNA is modified at the 5′ end of positive-strand...
51 KB (5,784 words) - 23:55, 12 April 2024
Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites...
3 KB (279 words) - 15:20, 26 August 2023
VSPs: viral envelope E1 E2 VNPs: P7 NS2 NS3 NS4A NS4B NS5A NS5B...
13 KB (1,457 words) - 17:30, 5 September 2024
structural (C, prM/M and E) and seven non-structural (NS1, NS2a, NS2b, NS3, NS4a, NS4b and NS5) proteins. The genome of KFDV is very similar (>92% homologous)...
24 KB (2,817 words) - 02:29, 30 August 2024
1b and targeting the HCV antigens nonstructural protein 3 (NS3) and 4A (NS4A), as well as NS4B and NS5A proteins. Following immunization, rhesus macaques...
8 KB (782 words) - 08:57, 5 January 2024
flies microcephaly appears to be caused by the flavivirid virus protein NS4A, which can disrupt brain growth by hijacking a pathway which regulates growth...
129 KB (12,099 words) - 16:49, 2 November 2024
and NS4B proteins to bind IKKε and prevent IRF3 phosphorylation and its NS4A protein, as per the zika virus, to bind MAVS to block RLR receptor binding...
25 KB (3,011 words) - 17:07, 24 May 2024
disabling the transport machinery of peroxisomal membrane proteins. The HCV NS3-NS4A strain inactivates MAVS signaling by cleaving the MAVS protein directly upstream...
16 KB (1,931 words) - 19:24, 19 August 2024
encoding 3374 amino acids. The ORF has the gene order C-prM-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5 which is consistent with mosquito- and tick-borne flaviviruses (Fig...
17 KB (2,111 words) - 18:50, 15 January 2024
envelope glycoproteins (E1 and E2), six nonstructural proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B), a truncated core protein (S, nucleocapsid), and an...
5 KB (579 words) - 02:06, 1 December 2023
Protein G, for proteins that interact with the Dengue Virus protein DENV-2 NS4A with the SBP-Tag and the Calmodulin Tag. and for proteins that interact with...
16 KB (1,719 words) - 15:57, 16 January 2024
of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide". Cell. 87 (2): 343–355. doi:10.1016/S0092-8674(00)81351-3...
23 KB (2,210 words) - 04:42, 30 November 2023
replication and assembly. These proteins are named NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5, and NS2K, where NS denotes “non-structural”. NS3 has enzymatic...
16 KB (2,022 words) - 03:15, 7 April 2023
of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide". Cell. 87 (2): 343–55. doi:10.1016/s0092-8674(00)81351-3...
2 KB (183 words) - 14:25, 26 August 2023
Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A". Journal of Virology. 94 (19). doi:10.1128/JVI.00420-20. ISSN 1098-5514...
10 KB (1,179 words) - 06:28, 28 March 2024
encoding over 3,000 amino acid polyproteins. The AnhC, PrM, M, NS2A, NS2B, NS3, NS4A, 2K, NS4B and NS5 proteins are all of the same length. ALKV owns the largest...
18 KB (1,755 words) - 02:16, 24 October 2024
envelope (E). The non-structural proteins include NS1, NS2A, NS2B, NS3, NS4A, 2K, NS4B, and NS5. Protein 2K is not found in many other flaviviruses. NS3...
11 KB (1,277 words) - 05:26, 10 May 2024
envelope (E), along with seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, 2K, NS4B, and NS5). The SPONV capsid is icosahedral and the similar to other...
14 KB (1,812 words) - 05:53, 9 August 2024