Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...
54 KB (6,141 words) - 03:36, 18 August 2024
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...
19 KB (1,978 words) - 11:32, 1 May 2024
Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform. The orexinergic nucleus in the lateral hypothalamus is...
5 KB (653 words) - 05:33, 8 December 2023
Narcolepsy (section Orexin replacement)
clinically characterized by symptoms of EDS and cataplexy, and/or will have CSF orexin levels of less than 110 pg/ml. Cataplexy are transient episodes of aberrant...
71 KB (8,196 words) - 12:40, 14 July 2024
gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and...
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Lateral hypothalamus (redirect from Orexin system)
(e.g., anandamide) and the orexin neuropeptides orexin-A and orexin-B are the primary signaling neurochemicals in orexin neurons; pathway-specific neurochemicals...
27 KB (3,032 words) - 13:35, 14 November 2023
Suvorexant (category Orexin antagonists)
Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...
94 KB (8,956 words) - 03:07, 14 August 2024
Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...
10 KB (1,104 words) - 02:20, 10 March 2024
Daridorexant (category Orexin antagonists)
Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken...
48 KB (4,078 words) - 11:27, 24 July 2024
colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1...
67 KB (7,709 words) - 06:15, 27 May 2024
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. It...
17 KB (1,672 words) - 02:28, 15 August 2024
hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition...
22 KB (2,504 words) - 00:21, 18 August 2024
Lemborexant (category Orexin antagonists)
Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...
21 KB (1,687 words) - 04:21, 27 January 2024
and associate with arousal. Orexin deficiency has been identified as responsible for narcolepsy. Research suggests that orexin and histamine neurons play...
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homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo-...
47 KB (4,229 words) - 19:27, 10 August 2024
Seltorexant (category Orexin antagonists)
an orexin antagonist medication which is under development for the treatment of depression and insomnia. It is a selective antagonist of the orexin OX2...
7 KB (498 words) - 07:20, 7 January 2024
Danavorexton (category Orexin receptor agonists)
Danavorexton (developmental code name TAK-925) is a selective orexin 2 receptor agonist. It is a small-molecule compound and is administered intravenously...
5 KB (301 words) - 11:39, 13 January 2024
Fluorenol (hydrafinil) Modafiendz (methylbisfluoromodafinil) Selective orexin receptor agonists (two are currently under development by Takeda, danavorexton...
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loss of approximately 70,000 orexin-releasing neurons in the lateral hypothalamus, resulting in significantly reduced orexin levels in the cerebrospinal...
49 KB (6,133 words) - 17:01, 26 July 2024
least some catabolic effects have been discovered, including cytokines, orexin (known as hypocretin), and melatonin.[citation needed] The word catabolism...
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sensed by glucose-inhibited neurons in the lateral hypothalamus. These orexin-expressing neurons appear to be hyperpolarised (inhibited) by a glucose-activated...
17 KB (1,778 words) - 16:33, 21 March 2024
Somnifacient (section Dual orexin receptor antagonist)
ramelteon. Dual orexin receptor antagonists are drugs that block the orexin receptors OX1 and OX2, hence reducing the wakeful effect of the orexin system and...
27 KB (2,930 words) - 09:17, 7 May 2024
(8–9): 405–11. doi:10.1016/j.mad.2011.06.005. PMC 3367503. PMID 21729715. Orexin receptor antagonists a new class of sleeping pill, National Sleep Foundation...
94 KB (8,341 words) - 08:44, 9 August 2024
approximately 70,000 orexin-releasing neurons in the lateral hypothalamus, leading to significantly reduced cerebrospinal orexin levels; this reduction...
58 KB (21,539 words) - 12:58, 7 August 2024
agonist Clonidine Guanfacine Cannabinoids Cannabidiol Tetrahydrocannabinol Orexin receptor antagonist Suvorexant Lemborexant Daridorexant Gabapentinoids Gabapentin...
43 KB (4,540 words) - 03:27, 25 June 2024
"Chapter 6: Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin". In Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation...
50 KB (4,969 words) - 01:43, 22 August 2024
approximately 70,000 orexin-releasing neurons in the lateral hypothalamus, leading to significantly reduced cerebrospinal orexin levels; this reduction...
45 KB (14,144 words) - 09:47, 21 August 2024
abstract). In specific subregions of each area, either opioid-stimulating or orexin-stimulating microinjections appear to enhance the number of liking reactions...
21 KB (2,625 words) - 23:40, 22 August 2024
approximately 70,000 orexin-releasing neurons in the lateral hypothalamus, leading to significantly reduced cerebrospinal orexin levels; this reduction...
273 KB (26,879 words) - 20:36, 4 August 2024
Insomnia (section Orexin antagonists)
antidepressants and antihistamines, quetiapine, orexin receptor antagonists, and melatonin receptor agonists, the orexin antagonist lemborexant and the Z-drug eszopiclone...
124 KB (15,159 words) - 05:55, 1 August 2024