• Thumbnail for Ryanodine
    Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide. The compound...
    4 KB (275 words) - 23:10, 12 November 2024
  • Ryanodine receptors (RyR for short) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons...
    21 KB (2,355 words) - 13:40, 24 June 2024
  • Thumbnail for Ryanodine receptor 1
    Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine...
    11 KB (1,344 words) - 03:32, 4 September 2024
  • Thumbnail for Catecholaminergic polymorphic ventricular tachycardia
    RYR2, which encodes a protein included in an ion channel known as the ryanodine receptor; this channel releases calcium from a cell's internal calcium...
    42 KB (4,764 words) - 15:55, 4 January 2024
  • Thumbnail for Ryanodine receptor 2
    Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2...
    16 KB (1,774 words) - 07:41, 11 November 2024
  • Thumbnail for Sarcoplasmic reticulum
    SR/terminal cisternae through a ryanodine receptor (RyR) and is known as a calcium spark. There are three types of ryanodine receptor, RyR1 (in skeletal muscle)...
    13 KB (1,810 words) - 15:53, 11 May 2024
  • Thumbnail for Malignant hyperthermia
    typically located on the long arm of chromosome 19 (19q13.2) involving the ryanodine receptor. More than 25 different mutations in this gene are linked with...
    45 KB (4,933 words) - 15:34, 26 July 2024
  • Thumbnail for Diamide insecticides
    active mainly against lepidoptera (caterpillars), which act on the insect ryanodine receptor. They are diamides of either phthalic acid or anthranilic acid...
    7 KB (669 words) - 04:56, 18 November 2024
  • Thumbnail for Ryanodine receptor 3
    Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene...
    10 KB (962 words) - 22:42, 16 July 2024
  • Thumbnail for Chlorantraniliprole
    Chlorantraniliprole opens muscular calcium channels, in particular the ryanodine receptor, rapidly causing paralysis and ultimately death of sensitive...
    3 KB (165 words) - 20:16, 12 November 2024
  • Thumbnail for Flecainide
    flecainide is useful to break a tachyarrhythmia. Flecainide also inhibits ryanodine receptor 2 (RyR2), a major regulator of sarcoplasmic release of stored...
    25 KB (2,632 words) - 13:08, 23 March 2024
  • Thumbnail for Flubendiamide
    Flubendiamide is the first insecticide of the diamide class. It acts on the ryanodine receptor. A metabolite of flubendiamide is very persistent and toxic to...
    3 KB (160 words) - 23:40, 12 November 2024
  • Thumbnail for Dantrolene
    Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention...
    17 KB (1,412 words) - 09:18, 27 September 2024
  • Thumbnail for Sarcomere
    with ryanodine receptors present on the sarcoplasmic reticulum. The inward flow of calcium from the L-type calcium channels activates ryanodine receptors...
    13 KB (1,609 words) - 18:28, 7 November 2024
  • Thumbnail for Muscle contraction
    proximity to ryanodine receptors in the adjacent sarcoplasmic reticulum. The activated dihydropyridine receptors physically interact with ryanodine receptors...
    62 KB (7,395 words) - 14:24, 5 October 2024
  • Mexican beaded lizard Heloderma horridum horridum. Helothermine inhibits ryanodine receptors, calcium channels and potassium channels. Helothermine can cause...
    4 KB (587 words) - 20:49, 9 January 2024
  • Thumbnail for T-tubule
    known as a ryanodine receptor, located on the cell's own internal calcium store, the sarcoplasmic reticulum. Activation of the ryanodine receptor causes...
    25 KB (3,239 words) - 16:16, 6 June 2024
  • with the release of calcium by binding to the ryanodine receptor and blocking the endogenous ligand ryanodine by competitive inhibition. Muscle that contracts...
    29 KB (3,122 words) - 16:58, 3 April 2024
  • glycolysis and a low pH within the muscle fibers. A mutation point in the ryanodine receptor gene (RYR1) in pork, associated to stress levels prior to slaughter...
    15 KB (1,989 words) - 16:08, 27 March 2024
  • Thumbnail for Spla/ryanodine receptor domain and socs box containing 3
    SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene. GRCh38: Ensembl release 89: ENSG00000162032...
    3 KB (361 words) - 15:00, 23 February 2024
  • The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members...
    14 KB (1,687 words) - 03:56, 29 November 2023
  • Thumbnail for Insecticide
    chemicals or environmental factors. Diamides selectively activate insect ryanodine receptors (RyR), which are large calcium release channels present in cardiac...
    52 KB (5,224 words) - 17:25, 17 November 2024
  • Thumbnail for Hadrucalcin
    the venom of the scorpion Hadrurus gertschi. Hadrucalcin modifies the Ryanodine receptor channels RyR1 and RyR2, found in the sarcoplasmic reticulum,...
    6 KB (609 words) - 04:32, 27 January 2024
  • occurs through an ion channel within the membrane of the SR, known as a ryanodine receptor (RyR), which opens upon activation. This process is important...
    18 KB (2,319 words) - 13:29, 23 July 2024
  • Thumbnail for Suramin
    rhodopsin, the A1 adenosine receptor, the D2 receptor, the P2 receptor, and ryanodine receptors. Suramin is also an inhibitor of ABC-type and P-type ATPases...
    23 KB (2,122 words) - 20:06, 9 October 2024
  • one of a group of short, basic peptides called calcins, which bind to ryanodine receptors (RyRs) and thereby trigger calcium release from the sarcoplasmic...
    9 KB (1,129 words) - 18:50, 30 April 2024
  • Thumbnail for Ruthenium red
    partners (e.g. TRPV4, ryanodine receptors,...). For example, it is a potent inhibitor of intracellular calcium release by ryanodine receptors (Kd ~20 nM)...
    6 KB (487 words) - 19:02, 22 September 2023
  • Thumbnail for Vejocalcin
    peptide (CPP); it binds with high affinity and specificity to skeletal ryanodine receptor 1 (RYR1) of the sarcoplasmic reticulum, thereby triggering calcium...
    13 KB (1,437 words) - 04:49, 24 July 2024
  • tetramethylazodicarboxamide Diamide insecticides, a class of insecticides targeting ryanodine receptors This set index article lists chemical compounds articles associated...
    277 bytes (68 words) - 04:20, 11 November 2024
  • Thumbnail for Skeletal muscle
    close to ryanodine receptors in the adjacent sarcoplasmic reticulum. The activated dihydropyridine receptors physically interact with ryanodine receptors...
    119 KB (13,834 words) - 10:47, 10 November 2024