of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6...

groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains...

important in activating critical transcription factor proteins such as STAT4 that are implicated in IL-12 signaling in T cells and NK cells. This pathway...

et al. (April 2009). "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in...

pro-inflammatory cytokines, including TNFα. Possible gene polymorphism: STAT4, PTPN2, PSORS1C1 and TRAF3IP2 genes had been correlated with response to...

ENSG00000168610 STAT Known motif – In vivo/Misc source [887] HTTCCYRKMA STAT4 ENSG00000138378 STAT Known motif – In vivo/Misc source [888] BDHTTCTBGKAAD...

and craniosynostosis syndromes Stat3 Lethal Tissue specific phenotypes Stat4 Viable defective IL-12-driven Th1 differentiation, increased susceptibility...

IgG B cells, and IFN-γ CD4 T cells. The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose...

SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK...

and Tyrosine kinase 2 transduce the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate transcription of target genes in nucleus. STAT3...

mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in...

P42224 15934 STAT2 HGNC:11363 P52630 15935 STAT3 HGNC:11364 P40763 15936 STAT4 HGNC:11365 Q14765 15937 STAT5A HGNC:11366 P42229 15938 STAT5B HGNC:11367...

polymorphisms located at six independent loci were also detected; IRF5, STAT4, BLK, IL12A, TNIP1, and CXCR5. This also suggested the activation of the...

IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important...

this signalization are IL-17A, IL-4 and IL-6. IL-18 with IL-12, which is a STAT4 activator, have similar effects on Th1 cells by up-regulating expression...

regulatory (Tr1) cells or T helper 17 (Th17) from naive T cells via STAT1, STAT4, and STAT5 phosphorylation. Several studies have shown that tumor-associated...

be induced via 2 independent signalling pathways, IFNg-STAT1 and IL-12-STAT4 pathways. Both need to cooperate to reach stable Th1 phenotype. Th1 phenotype...

inducing MS type II demyelination (pattern II) Deficiency of TBX21 or STAT4 provides resistance against EAE, while interferon-γ-, interferon-γ-receptor-...

to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling...

modulates gene expression. Additionally, transcription factors, including STAT4 and RUNX family transcription factors play a role in the introduction of...

Vol. 80, 2007, pp. 867-875 doi:10.1086/516736 with E.F. Remmers et al.: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. In:...

IFNAR2 recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain cell types) via their SH2 domains...

Gulba DC (August 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal...

identification of STAT4 as a key transcription factor responsible for influencing the regulation of many target genes involved in DLE. STAT4 is a very important...

Somatic hypermutation Specific granule Specol STAT protein STAT1 STAT2 STAT3 STAT4 STAT5 STAT6 Stem cell educator Stimulator of interferon genes Stromal cell-derived...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

signalling cascade formed by TYK and JAK2 kinases, eventually leading to STAT4 phosphorylation and nuclear translocation. The final response to IL12 stimulation...

BB, Niu P, Surowy CS, Faltynek CR (August 1999). "Direct interaction of STAT4 with the IL-12 receptor". Archives of Biochemistry and Biophysics. 368 (1):...

R, et al. (August 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal...

Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, et al. (April 2007). "Stat3 and Stat4 direct development of IL-17-secreting Th cells". Journal of Immunology....