Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix...
6 KB (643 words) - 22:25, 15 September 2024
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric...
19 KB (2,345 words) - 04:52, 3 June 2024
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is...
12 KB (1,420 words) - 09:40, 14 January 2024
Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. The protein encoded by this gene belongs to the thrombospondin protein family...
6 KB (709 words) - 23:19, 27 March 2024
Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. The protein encoded by this gene belongs to the thrombospondin family...
7 KB (823 words) - 07:13, 27 September 2024
genetic mutations associated with congenital glaucoma, such as the thrombospondin-1 (THBS1) gene. The condition is often caused by developmental anomalies...
12 KB (1,298 words) - 04:30, 22 December 2024
Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is...
9 KB (1,050 words) - 04:06, 17 June 2024
Cagla Eroglu (category Thrombospondins)
specifically through the release of thrombospondin. A further in depth analysis into the role of thrombospondin and their receptors α2δ-1, which Eroglu...
20 KB (2,179 words) - 22:45, 7 November 2023
disease. MiR-27b also targets Thrombospondin-1, an antiangiogenic protein. Reduction in miR-27b increases Thrombospondin-1 levels, which decreases angiogenesis...
4 KB (415 words) - 04:07, 22 January 2021
macrophages where the latent TGF-β complex is bound to CD36 via its ligand, thrombospondin-1 (TSP-1). Inflammatory stimuli that activate macrophages enhance the...
67 KB (8,184 words) - 08:20, 28 December 2024
CD47 (section Thrombospondin (TSP))
superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as...
37 KB (4,268 words) - 02:57, 4 November 2024
A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. ADAMTS5...
12 KB (1,458 words) - 16:40, 5 June 2024
type V, alpha 2 (COL5A2) Mucin 2 (MUC2) Mucin 5B (MUC5B) Thrombospondin 1 (THBS1) Thrombospondin 2 (THBS2) SCO-spondin (SSPO) CCN1: Cysteine-rich angiogenic...
5 KB (570 words) - 01:53, 31 December 2020
integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs...
15 KB (1,821 words) - 23:09, 9 November 2024
ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene. This gene encodes a member of the...
5 KB (649 words) - 04:13, 25 December 2024
ADAM metallopeptidase with thrombospondin type 1 motif 6 is a protein that in humans is encoded by the ADAMTS6 gene. This gene encodes a member of the...
3 KB (392 words) - 02:38, 26 January 2023
Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins". Journal of Pharmacology and Experimental Therapeutics. 374 (1): 161–174...
31 KB (3,424 words) - 21:36, 22 December 2024
glutamate receptors and also with the extracellular matrix protein, thrombospondin, and to modulate the function of these proteins. This has been proposed...
98 KB (8,650 words) - 09:45, 22 December 2024
common. Examples of TAF-derived ECM components include Tenascin and Thrombospondin-1 (TSP-1), which can be found in sites of chronic inflammation and carcinomas...
14 KB (1,676 words) - 08:20, 4 September 2024
A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. This gene encodes a member...
13 KB (1,619 words) - 02:57, 28 November 2023
that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family. Aggrecanases act on large proteoglycans known as aggrecans...
3 KB (296 words) - 16:35, 12 May 2024
cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density...
44 KB (5,085 words) - 16:18, 13 October 2024
and AMPA-type glutamate receptors at presynaptic sites and also with thrombospondin (an extracellular matrix protein secreted by astroglial cells). Gabapentin...
99 KB (9,920 words) - 05:56, 31 December 2024
metalloproteinase with thrombospondin motifs 1 ADAMTS5: encoding enzyme a disintegrin and metalloproteinase with thrombospondin motifs 5 ADARB1: encoding...
33 KB (3,074 words) - 21:55, 28 December 2024
and gene expression, and promotes excitatory synaptogenesis through thrombospondin 1. Gabapentinoids are not direct channel blockers; rather, they disrupt...
130 KB (13,432 words) - 06:24, 11 September 2024
for a Microsoft API Thiele/Small parameters, of a loudspeaker driver Thrombospondin, protein Time stamp protocol in cryptography Titanium sublimation pump...
2 KB (257 words) - 23:20, 18 September 2024
in selenium and selenium uptake mechanisms result in brain damage. Thrombospondin is a protein found in the extracellular matrix that competes with reelin...
27 KB (3,439 words) - 10:00, 27 March 2024
Oncology, ABT-510 is a "subcutaneously (SC) administered nonapeptide thrombospondin analogue." Following inconclusive phase I clinical trials, a 2007 phase...
3 KB (216 words) - 14:53, 28 August 2023
PLA2R autoantibodies. In 2014, a second autoantigen was discovered, the thrombospondin type 1 domain-containing 7A (THSD7A) system that might account for an...
22 KB (2,293 words) - 13:53, 22 September 2024
MED. Lack of COMP was not compensated for by any other protein in the thrombospondin family. This study confirmed that the disease is not caused by reduced...
23 KB (2,399 words) - 21:37, 1 November 2024