Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions...
32 KB (3,109 words) - 06:12, 10 June 2024
TYRP1 (redirect from Tyrosinase-related protein 1)
Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme which in humans is encoded by the TYRP1 gene. Tyrp1 is a melanocyte-specific...
17 KB (2,071 words) - 01:48, 28 November 2023
Albinism (redirect from Oculocutaneous albinism, tyrosinase positive)
complex process involving the enzyme tyrosinase. Mammals have a gene that codes for the presence of tyrosinase in cells – called the TYR gene. If this...
73 KB (8,236 words) - 16:34, 8 July 2024
"Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing". Ophthalmic Genetics...
13 KB (665 words) - 15:43, 3 February 2024
arbutin (β-arbutin), and like the β-form it is an enzyme inhibitor of human tyrosinase. α-Arbutin is used in the cosmetic and pharmaceutical industries for its...
10 KB (779 words) - 11:28, 29 March 2024
Skin whitening (section Inhibition of tyrosinase)
of tyrosinase: The catalytic action of tyrosinase is inhibited by the skin whitening agent. Inhibition of the expression or activation of tyrosinase: The...
65 KB (7,447 words) - 18:17, 23 June 2024
oculocutaneous albinism that is caused by a dysfunction in the gene for tyrosinase (symbol TYR or OCA1). The location of OCA1 may be written as "11q1.4–q2...
14 KB (1,600 words) - 02:27, 12 June 2024
believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone...
2 KB (83 words) - 02:46, 21 October 2023
hyperpigmentation issues. Its mechanism of action involves inhibiting the activity of tyrosinase, an essential enzyme for melanin synthesis in the human skin, thereby...
16 KB (1,374 words) - 08:12, 11 March 2024
action of PPOs to form o-quinone. Hence, PPOs may also be referred to as tyrosinases. Common foods producing the enzyme include mushrooms (Agaricus bisporus)...
27 KB (3,072 words) - 22:54, 27 September 2023
all vertebrates, including humans. It is due to absence or defect of tyrosinase, a copper-containing enzyme involved in the production of melanin. Unlike...
39 KB (3,840 words) - 17:09, 9 July 2024
is a form of partial albinism resulting from a mutation that affects tyrosinase, an enzyme involved with melanin production. The mutated enzyme is thermolabile;...
14 KB (1,653 words) - 20:47, 1 March 2024
being a component of a number of hair and skin conditioners. AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid...
17 KB (1,613 words) - 16:39, 12 May 2024
l-DOPA are all precursors to the biological pigment melanin. The enzyme tyrosinase catalyzes the oxidation of l-DOPA to the reactive intermediate dopaquinone...
30 KB (2,973 words) - 08:45, 13 June 2024
Dopachrome tautomerase (redirect from Tyrosinase-related protein 2)
regulated by the microphthalmia-associated transcription factor (MITF). Tyrosinase-related protein 1 (TYRP1) Dopachrome, a cyclization product of L-DOPA...
8 KB (1,029 words) - 13:17, 18 August 2023
organelles called melanosomes. This reaction is catalyzed by the enzyme tyrosinase. The initial product, dopaquinone can transform into either 5,6-dihydroxyindole...
59 KB (6,397 words) - 14:52, 20 June 2024
albinism, resulting from a mutation in tyrosinase, an enzyme involved in melanin production. The mutated tyrosinase enzyme is heat-sensitive; it fails to...
35 KB (4,041 words) - 23:42, 1 July 2024
(dipteran) hexamerin receptors. Phenoloxidase are copper containing tyrosinases. These proteins are involved in the process of sclerotization of arthropod...
24 KB (2,620 words) - 20:14, 27 June 2024
Studies have shown that the reduced pigment comes from a mutation in the gene for tyrosinase, the same as causes Type I oculocutaneous albinism in humans....
10 KB (876 words) - 11:38, 30 April 2024
Poly-γ-glutamate is a metabolite of Bacillus subtilis. Poly-γ-glutamate inhibits tyrosinase and melanogenesis in vitro. Liu, X.; Liu, F.; Liu, S.; Li, H.; Ling, P...
1 KB (62 words) - 01:48, 30 January 2023
OCA1A, which impairs tyrosinase production. In other mammals, the diagnosis of albinism is based on the impairment of tyrosinase production through defects...
29 KB (3,590 words) - 06:58, 7 June 2024
turn, decreases the expression of the melanin main synthesizing enzymes: tyrosinase, TRP-1 and TRP-2. BW-723C86 is not cytotoxic to melanocytes and, unlike...
7 KB (625 words) - 23:26, 2 February 2024
pattern [1] is a form of partial albinism, resulting from a mutation in tyrosinase, an enzyme involved in melanin production. The mutated enzyme is heat-sensitive;...
14 KB (1,686 words) - 06:09, 12 May 2024
melanin, removing all black pigmentation. However, they are believed to be tyrosinase-positive (hence the T+), and therefore can still create some darker pigments...
34 KB (3,474 words) - 23:58, 8 July 2024
a mouse model of hyperoxaluria. Tiliroside from raspberry is a potent tyrosinase inhibitor and might be used as a skin-whitening agent and pigmentation...
12 KB (1,156 words) - 21:55, 21 April 2024
example of such a protein is the enzyme tyrosinase, which is required for melanin production. Normally tyrosinase is produced in minute quantities but its...
8 KB (863 words) - 13:17, 7 April 2024
Tyrosinemia type II is an autosomal recessive condition with onset between ages 2 and 4 years, when painful circumscribed calluses develop on the pressure...
4 KB (298 words) - 22:58, 6 November 2023
pigments called melanins, commonly associated with a genetic loss of tyrosinase function. Amelanism can affect fish, amphibians, reptiles, birds, and...
14 KB (1,537 words) - 21:02, 20 September 2023
the fact that the people in these regions tend to have lower levels of tyrosinase in their bodies. Black eumelanin secretion causes the hair to turn black...
22 KB (2,434 words) - 23:51, 27 June 2024
2010, ISBN 3-8383-4661-0, ISBN 978-3-8383-4661-8 Inhibition of mushroom tyrosinase by tropolone. Varda Kahn and Andrawis Andrawis, Phytochemistry, Volume...
17 KB (1,188 words) - 20:48, 19 May 2024