5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ direction. This gene encodes...

exonucleases involved in the normal turnover of mRNA: 5′ to 3′ exonuclease (Xrn1), which is a dependent decapping protein; 3′ to 5′ exonuclease, an independent...

joined by the decapping activator Dcp1, the helicase Dhh1, the exonuclease Xrn1, nonsense mediated decay factors Upf1, Upf2, and Upf3, the LSm complex, Pat1...

YFV 3′UTR region is required for stalling of the host 5′-3′ exonuclease XRN1. The UTR contains PKS3 pseudoknot structure, which serves as a molecular...

allowing for the 5' to 3' exoribonuclease Xrn1 to degrade the transcript completely. The role of Dcp1-Dcp2 and Xrn1 in cytoplasmic decay has also been found...

degradation of genomic viral RNA by the host cells 5'-3' exoribonuclease 1 (XRN1). As the XRN1 degrades viral RNA, it stalls at stemloops formed by the secondary...

transcribed spacer region 2 (ITS2). XRN1 is an exonuclease that degrades the ITS2 region during processing of RN45s. Reduction of XRN1 under d-flow conditions therefore...

PMID 28965817. Long, Roy M.; McNally, Mark T. (2003-05-01). "mRNA Decay: X (XRN1) Marks the Spot". Molecular Cell. 11 (5): 1126–1128. doi:10.1016/S1097-2765(03)00198-9...

removal of the mRNA's 5' cap. 5'-to-3' degradation of the transcript occurs by XRN1 exonuclease in cytoplasmic bodies called P-bodies. 3'-to-5' degradation of...

the 3' fragment is degraded from its 5' end by 5' -3' exoribonuclease 1(XRN1). Dissociation of the target mRNA strand from RISC after the cleavage allow...

A host of proteins accompany it including UPF1, UPF2, UPF3A, Dcp1, Dhh1, XRN1, and others. The decapping enzyme removes the 5' cap leading to destruction...

produced by incomplete degradation of the viral genome by the host cell (via XRN1). Local RNA secondary structures (xrRNA elements) in the 3' UTR and long-range...

decay is initiated by the removal of the 5’ cap followed by degradation by XRN1, an exoribonuclease enzyme. The other pathway by which mRNA is degraded is...

sites of mRNA degradation because they contain enzymes such as DCP1/2 and XRN1 that are known to degrade mRNA. However, others have demonstrated that mRNA...

Murphy, and Steven A. Soper, ACS Sensors 6 (2021) 1831–1839. Solid-Phase XRN1 Reactions for RNA Cleavage: Application in Single-Molecule Sequencing, Uditha...

of the 5′-UTR of CLB2 mRNA that allows for rapid 5′-to-3′ degradation by XRN1, an exoribonuclease enzyme. RNase P and RNAse MRP are ribonucleoprotein complexes...

eukaryotes, this 5' monophosphate is a substrate for the 5' exonuclease Xrn1 and the mRNA is quickly destroyed. There are many situations which may lead...

Q13426 18406 XRCC5 HGNC:12833 P13010 18407 XRCC6 HGNC:4055 P12956 18408 XRN1 HGNC:30654 Q8IZH2 18409 XRN2 HGNC:12836 Q9H0D6 18410 XRRA1 HGNC:18868 Q6P2D8...

RNA strand and halts transcriptions upon catching up to the polymerase. Xrn1 GRCh38: Ensembl release 89: ENSG00000088930 – Ensembl, May 2017 GRCm38: Ensembl...

molecules are then fully degraded by the exosome in a 3' to 5' fashion and by Xrn1 in a 5' to 3' fashion. It is not currently known how this process releases...