Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver...
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Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be inherited or acquired. It is a rare...
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Coagulation (section Antithrombin)
Factor V or high levels of FVIII, also may lead to a thrombotic tendency. Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases:...
64 KB (6,553 words) - 17:35, 26 October 2024
approves Antithrombin as an anticoagulant for preventing clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency...
78 KB (8,755 words) - 07:51, 27 October 2024
Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in...
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and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time. However, protamine...
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direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa. Fondaparinux...
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transaccional (Spanish for "transactional analysis"), a psychological method Antithrombin, a small protein molecule Ataxia–telangiectasia, an immunodeficiency...
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and rechecking laboratory values. Use in antithrombin III deficiency: FFP can be used as a source of antithrombin III in patients who are deficient of this...
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774–77. PMID 9666418. MedlinePlus Encyclopedia: 003652 Antithrombin III at eMedicine Antithrombin CO000300 in Coagulation Test Handbook at Massachusetts...
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the coagulation cascade. In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels...
25 KB (2,932 words) - 09:48, 19 October 2024
glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It...
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ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics (formerly known as GTC Biotherapeutics)...
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first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, while the most common abnormalities...
47 KB (5,585 words) - 01:20, 24 September 2024
reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, with the subsequent recognition...
137 KB (14,301 words) - 14:45, 2 November 2024
principal inhibitor of thrombin in normal blood circulation is antithrombin. Similar to antithrombin, the anticoagulant activity of hirudin is based on its ability...
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Rhophylac (Rh(D) immunoglobulin G) Tetanus Immunoglobulin-VF Thrombotrol-VF (antithrombin III) Vivaglobin, sub-cutaneous human immune globulin indicated for the...
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lead to mutations through intrastrand and interstrand switching. The antithrombin III gene's coding region is an example of an imperfect inverted repeat...
31 KB (3,451 words) - 20:17, 11 September 2024
VTE rates. Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factor V Leiden and prothrombin...
144 KB (14,633 words) - 21:58, 16 October 2024
cascade. Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin and factor Xa. In contrast...
21 KB (2,279 words) - 02:02, 18 September 2024
"Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational...
25 KB (3,112 words) - 19:03, 28 February 2024
the Antithrombin molecules in neonates and children is larger than in adults. Antithrombin: the levels of antithrombin increase with age. Antithrombin levels...
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particularly those caused by a decrease in blood antithrombin III levels due to leakage. Antithrombin III counteracts the action of thrombin. Thrombosis...
57 KB (6,362 words) - 01:53, 28 October 2024
By cause Clotting factors Antithrombin III deficiency Protein C deficiency Activated protein C resistance Protein S deficiency Factor V Leiden Prothrombin...
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reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial...
37 KB (3,908 words) - 07:09, 11 May 2024
Human immunoglobulin for anti-tetanus use and antithrombin produced by Grifols....
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determine the safety, dosing, and effectiveness of prophylactic heparin and antithrombin treatment for preterm neonates. In infants, germinal matrix hemorrhage...
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An extremely rare form of Pi, termed PiPittsburgh, functions as an antithrombin (a related serpin), due to a mutation (Met358Arg). One person with this...
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screen- to detect chronic venous thromboembolism (proteins C and S, antithrombin III, homocysteine levels) The diagnosis of pulmonary heart disease is...
14 KB (1,323 words) - 04:52, 10 April 2024
excessive protease-triggered activation of its own complement system), antithrombin (which protects the body from excessive coagulation), plasminogen activator...
26 KB (2,799 words) - 15:02, 30 June 2024