chemical antibodies. Aptamers and antibodies can be used in many of the same applications, but the nucleic acid-based structure of aptamers, which are mostly...
60 KB (6,559 words) - 14:38, 19 June 2024
bacteria cells, metal ions, etc. Aptamers can be developed to have precise specificity to bind to a desired target. Aptamers change conformation upon binding...
28 KB (3,388 words) - 18:44, 10 July 2024
RNA therapeutics (section RNA aptamers)
utilized to select RNA aptamers, RNA aptamers can be generated for many potential targets. By directly introducing the RNA aptamers to the target during...
77 KB (8,886 words) - 09:03, 10 June 2024
Systematic evolution of ligands by exponential enrichment (section SELEX variants and alternative aptamer selection methods)
possible aptamers, is also expanded using unnatural base pairs the use of these unnatural base pairs was applied to SELEX and high affinity DNA aptamers were...
41 KB (4,741 words) - 05:07, 22 April 2024
Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was...
23 KB (2,660 words) - 05:35, 3 June 2024
synthetically derived RNA aptamer born out of the need for a way of studying the role of RNAs at the cellular level. This aptamer was created using Systematic...
5 KB (637 words) - 13:11, 4 October 2023
oligonucleotides. L-RNA aptamers are a form of aptamers. Due to their L-nucleotides, they are highly resistant to degradation by nucleases. L-RNA aptamers are considered...
6 KB (635 words) - 10:43, 7 September 2021
Smart ligand (redirect from Smart aptamers)
Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set...
4 KB (390 words) - 03:56, 27 December 2023
known different activity depending on enantiomeric form, Aptamers (L-ribonucleic acid aptamers): "That makes mirror-image biochemistry a potentially lucrative...
14 KB (1,604 words) - 18:14, 23 May 2024
reported that two aptamers might bind and inhibit GPCR-AABs. The biotechnology company Berlin Cures pursued the development of the aptamer with the nucleotide...
17 KB (1,148 words) - 17:38, 23 July 2024
from nucleic acids, as in the case of aptamers, or from non-immunoglobulin protein scaffolds / peptide aptamers, into which hypervariable loops are inserted...
9 KB (1,198 words) - 00:55, 27 November 2023
usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind...
4 KB (439 words) - 00:00, 1 July 2024
materials used in sensor development are molecularly imprinted polymers and aptamers. A chemical sensor array is a sensor architecture with multiple sensor...
25 KB (3,169 words) - 14:41, 22 July 2024
PMID 12351145. Babendure, Jeremy R.; Adams, Stephen R.; Tsien, Roger Y. (2003). "Aptamers Switch on Fluorescence of Triphenylmethane Dyes". Journal of the American...
18 KB (1,769 words) - 06:56, 28 June 2024
2014). "Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo". FASEB Journal. 28 (1): 464–73. doi:10.1096/fj.13-234229. PMC 3868842...
91 KB (10,689 words) - 17:16, 24 July 2024
and streptavidin proteins. DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in...
166 KB (17,856 words) - 06:01, 11 July 2024
translated into protein, and cell death ensues. Tobramycin also binds to RNA-aptamers, artificially created molecules to bind to certain targets. However, there...
19 KB (1,657 words) - 07:44, 19 May 2024
"Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2". Biochemistry. 46 (48): 13742–51. doi:10.1021/bi7008739...
42 KB (4,305 words) - 02:59, 22 July 2024
immuno-RCA, the ssDNA RCA primer can be conjugated to the 3' end of a DNA aptamer as well. The primer tail can be amplified through rolling circle amplification...
24 KB (2,920 words) - 14:34, 16 July 2024
been used to study protein DNA interactions Acrydite-modified aptamers (and also aptamers containing internal acrylamide modifications) have been used...
6 KB (646 words) - 19:51, 15 March 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
31 KB (3,413 words) - 23:30, 21 June 2024
specifically bind antigens. They consist of artificial peptides or proteins, or aptamer-based nucleic acid molecules with a molar mass of about 3 to 20 kDa. Antibody...
118 KB (13,245 words) - 15:06, 21 July 2024
generation aptamer technology, Optimer ligands were produced to improve the performance, manufacturability, and commercialisation of aptamers. Optimer ligands...
16 KB (1,551 words) - 23:22, 10 December 2023
latter, aptamers generated against the target recognise it via interplay of specific non-covalent interactions and induced fitting. These aptamers can be...
104 KB (12,037 words) - 18:54, 25 May 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
34 KB (3,021 words) - 04:42, 11 July 2024
diseases. Other potential drugs in pre-clinical development are agonist CD28 aptamers with immunostimulatory properties in a mouse tumor model, a monoclonal...
27 KB (3,419 words) - 16:44, 7 May 2024
IL-1α and the aptamer. Huang et al. uses ACE to investigate protein-protein interactions using aptamers. A α-thrombin binding aptamer was labeled with...
36 KB (4,675 words) - 21:03, 7 June 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
150 KB (15,741 words) - 10:54, 25 July 2024
Biology List of RNA Biologists RNA Society Macromolecule RNA-based evolution Aptamer RNA origami Transcriptome RNA world hypothesis Copley SD, Smith E, Markowitz...
65 KB (7,640 words) - 14:15, 22 July 2024
Novartis purchased the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments)...
144 KB (12,103 words) - 12:55, 25 July 2024