protein that in humans is encoded by the BCL9 gene. BCL9, together with its paralogue gene BCL9L (BCL9 like or BCL9.2), have been extensively studied for...
10 KB (1,269 words) - 19:04, 6 June 2024
interaction between the Wnt-dependent transcriptional co-factors beta-catenin and BCL9. It is related to mebendazole by replacement of the left most benzene ring...
5 KB (482 words) - 00:38, 6 December 2022
factors. β-catenin recruits other transcriptional coactivators, such as BCL9, Pygopus and Parafibromin/Hyrax. The complexity of the transcriptional complex...
64 KB (7,432 words) - 08:21, 28 October 2024
between alpha-catenin and E-cadherin or between TCF1 and BCL9, respectively. On the other hand, BCL9 and BCL9L must compete with α-catenin to access β-catenin...
107 KB (12,347 words) - 05:01, 2 November 2024
malignancies. Members include: CCND1 (also known as "BCL1") BCL2 BCL3 BCL5 BCL6, BCL6B BCL7A, BCL7B, BCL7C BCL8 BCL9 BCL10 BCL11A, BCL11B Bcl-2 family v t e...
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Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell. 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001...
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which complete genome data are available. Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. The two isoforms of...
41 KB (4,564 words) - 10:38, 29 September 2024
a number of cancers. Other BCL genes, including BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, also have clinical significance in lymphoma. The protein encoded...
20 KB (2,414 words) - 11:10, 15 July 2024
of the complex.[citation needed] In the nucleus it complexes with legless/BCL9, TCF, and Pygo.[citation needed] The ability of APC to bind β-catenin has...
28 KB (3,225 words) - 01:48, 6 May 2024
structure is still unknown; other proteins, such as the Wnt signaling components BCL9 and Pygopus, have been implicated in this process. During this process, amelogenins...
52 KB (6,229 words) - 00:21, 13 February 2024
ARNT (1q21) ASPM (1q31): a brain size determinant ATF3 (1q32) ATP2B4 (1q32) BCL9 (1q21) CATSPERE: encoding protein Catsper channel auxiliary subunit epsilon...
46 KB (3,290 words) - 20:16, 17 August 2024
defects and abnormalities of the upper limb. The Wnt signaling co-factors BCL9, BCL9L and PYGO might be part of these molecular pathways, as when their...
49 KB (4,961 words) - 08:51, 15 November 2024
effectors of proper lens development include the Wnt signaling components BCL9 and Pygo2. The whole process of differentiation of the epithelial cells into...
53 KB (6,530 words) - 21:23, 23 October 2024
humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma. Bcl10 was identified by its translocation...
15 KB (1,813 words) - 14:39, 26 January 2024
controls the nuclear residence of p50 NF-kappa B. Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. BCL3 has been shown...
23 KB (2,553 words) - 23:08, 3 August 2024
duplications at 16p11.2 are at 7.5% or higher. Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also...
21 KB (2,208 words) - 12:57, 24 September 2024
HGNC:1004 Q4VC05 1484 BCL7B HGNC:1005 Q9BQE9 1485 BCL7C HGNC:1006 Q8WUZ0 1486 BCL9 HGNC:1008 O00512 1487 BCL9L HGNC:23688 Q86UU0 1488 BCL10 HGNC:989 O95999...
277 KB (17 words) - 18:34, 6 October 2024
related to the distal area are PDE4DIP, HYDIN2, PRKAB2, PDIA3P, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, NBPF10, GPR89B, GPR89C, PDZK1P1 and NBPF11. Understanding...
6 KB (832 words) - 17:31, 29 September 2024
Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex"...
4 KB (571 words) - 13:44, 2 November 2024
duplications at 16p11.2 are at 7.5% or higher. Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also...
21 KB (2,031 words) - 19:58, 29 October 2024
factors during lens development. They include the transcriptional activator BCL9, recently identified, together with Pygo2, to be downstream effectors of...
22 KB (2,710 words) - 15:03, 21 December 2023
of the Wnt signaling pathway leads to the association of β-catenin with BCL9, translocation to the nucleus, and association with TCF7L2, which in turn...
43 KB (4,341 words) - 05:18, 28 October 2024
"Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9". eLife. 6. doi:10.7554/eLife.20882. ISSN 2050-084X. PMC 5352222. PMID 28296634...
12 KB (928 words) - 04:14, 6 August 2024
regulation of Wnt target genes by tissue-specific crosstalk with the protein BCL9. Embryonic stem cells (ESCs) and adult stem cells, are undifferentiated cells...
39 KB (4,686 words) - 17:28, 22 August 2024