Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis)...
41 KB (4,564 words) - 08:17, 5 August 2024
The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most...
16 KB (2,160 words) - 15:56, 7 April 2024
Apoptosis regulator BAX (redirect from Bcl-2–associated death protein)
regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene family. BCL2 family...
18 KB (2,108 words) - 13:17, 21 December 2023
actress and singer Members of the Bcl-2 family, a group of related proteins involved in apoptosis, particularly bcl-2 Baltimore Catholic League Bangladesh...
2 KB (312 words) - 12:48, 3 November 2023
Inhibitor of apoptosis (section Bcl-2 family)
the mitochondria. The Bcl-2 family of proteins can either inhibit or promote apoptosis and members are characterized by the Bcl-2 homologous domains BH1...
12 KB (1,527 words) - 02:23, 14 August 2024
Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. The protein encoded by this gene is known to interact with cellular and...
10 KB (1,379 words) - 00:47, 2 December 2023
of the human proteins Bcl-xL and Bcl-xS. The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers...
19 KB (2,223 words) - 05:29, 3 January 2024
Akt/PKB signaling pathway (redirect from PI/PI3K/AKT/BCL-2 pathway)
to the promoter of target genes, such as Bcl-2. Akt has also been shown to phosphorylate murine double minute 2 (Mdm2), a key regulator of DNA damage responses...
37 KB (4,145 words) - 08:04, 3 July 2024
lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins...
7 KB (884 words) - 21:39, 24 July 2024
member of the Bcl-2 gene family which is involved in initiating apoptosis. BAD is a member of the BH3-only family, a subfamily of the Bcl-2 family. It does...
17 KB (1,980 words) - 03:17, 18 March 2024
gene bcl-2. Researchers had been hot in the track of oncogenes, and now more and more of the pieces were falling into place. However, although bcl-2 was...
12 KB (1,598 words) - 09:38, 22 June 2024
Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. German scientist Carl Vogt was first...
91 KB (10,659 words) - 02:42, 7 July 2024
Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. It belongs to the BCL2 protein family. BCL2...
21 KB (2,597 words) - 09:19, 7 July 2024
its polyclonality and lack of bcl-2 protein expression, whereas follicular lymphoma is monoclonal, and expresses bcl-2. Lymphadenopathies such as follicular...
19 KB (2,205 words) - 03:58, 23 September 2023
Bachelor of Civil Law (redirect from B.C.L.)
(abbreviated BCL or B.C.L.; Latin: Baccalaureus Civilis Legis) is the name of various degrees in law conferred by English-language universities. The BCL originated...
14 KB (1,994 words) - 11:53, 8 January 2024
throat infection and tiredness. Venetoclax attaches to a protein called Bcl-2. This protein is present in high amounts in CLL cancer cells, where it helps...
27 KB (2,564 words) - 02:20, 16 July 2024
(containing the BCL-2 locus) is present in 45% of GCB DLBCLs but has never been found in ABC DLBCLs. This T(14,18) translocation places the BCL-2 gene close...
20 KB (2,453 words) - 10:36, 1 June 2024
BCL2L11 (category Genes on human chromosome 2)
Bcl-2-like protein 11, commonly called BIM (Bcl-2 Interacting Mediator of cell death), is a protein that in humans is encoded by the BCL2L11 gene. The...
11 KB (1,403 words) - 16:01, 15 March 2024
member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. Like many of the Bcl-2 family proteins, BNIP3...
21 KB (2,672 words) - 09:34, 2 January 2024
mentioning that inhibit the release of cytochrome c in the mitochondria. Bcl-2 and Bcl-xl are anti-apoptotic and therefore prevent cell death. There is a potential...
55 KB (6,757 words) - 17:12, 15 July 2024
Oblimersen (redirect from Bcl-2 antisense oligodeoxynucleotide G3139)
Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide...
8 KB (398 words) - 11:47, 22 June 2024
of the gene Bcl-2. Korsmeyer went on to start his own laboratory at Washington University in St. Louis, further studying the role of Bcl-2 in cell biology...
13 KB (1,357 words) - 20:08, 12 August 2023
anti-cancer drug, which is a Bcl-2 inhibitor similar in action to obatoclax. Navitoclax inhibits not only Bcl-2, but also Bcl-XL and Bcl-w proteins. Because navitoclax...
13 KB (1,220 words) - 19:27, 12 August 2024
member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH)...
11 KB (1,246 words) - 11:37, 4 March 2023
(PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component...
28 KB (3,387 words) - 06:12, 27 December 2023
Its product, Bcl-2 protein, regulates cellular apoptosis by inhibiting the apoptosis-causing proteins, Bcl-2-associated X protein and Bcl-2 homologous antagonist...
69 KB (8,143 words) - 18:36, 22 January 2024
molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains....
7 KB (649 words) - 12:44, 17 January 2024
J, Ackler S, Refici M, Ferguson D, et al. (June 2008). "Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft...
26 KB (2,028 words) - 10:24, 8 June 2024
Champions League will be the 9th season of the Basketball Champions League (BCL), the European professional basketball competition for clubs launched by...
28 KB (999 words) - 21:45, 18 August 2024