CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules...
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antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces...
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As assistant professor at Columbia, Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. He also collaborated...
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BAFF (CD257, TNFSF13B) CAML CD70 (CD27L, TNFSF7) CD153 (CD30L, TNFSF8) CD154 (CD40L, TNFSF5) Ectodysplasin (A, A2) FasL (CD95L, TNFSF6) GITRL (TNFSF18)...
49 KB (6,227 words) - 14:52, 18 November 2024
antigen-presenting cells by the CD4+ T helper cells proceeds by signaling between CD154/CD40L on the T helper cell and the CD40 receptor on the antigen-presenting...
31 KB (3,852 words) - 12:14, 31 December 2024
immune response.[citation needed] In 1991, three groups reported discovering CD154, which is the molecular basis of T cell helper function. Seth Lederman at...
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molecule CD154 (CD40L). Platelets are activated by inflammation, infection, or injury, and after their activation microvesicles containing CD154 are released...
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to develop TNX-1500, a humanized monoclonal antibody (mAb) that targets CD154 for the prevention and treatment of organ transplant rejection. In January...
48 KB (5,279 words) - 23:45, 20 September 2024
molecules expressed on the T cell's surface, such as CD40 ligand (also called CD154), which provide extra stimulatory signals typically required to activate...
118 KB (13,487 words) - 01:29, 28 November 2024
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Szodoray P, Loro LL, Johannessen AC, Jonsson R (December 2002). "CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative...
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humanized IGF-1 receptor (CD221) cancer etc. Dapirolizumab pegol mab humanized CD154 (CD40L) Daratumumab Darzalex mab human CD38 Y multiple myeloma Dectrekumab...
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overexpressed. The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, and cytochrome c release NF-κB...
59 KB (5,773 words) - 01:40, 24 October 2024
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protein found on antigen presenting cells. CD40 combines with its ligand CD154 (CD40L) on T cells to induce antibody isotype switching in B cells. Under...
96 KB (492 words) - 06:06, 25 November 2024
CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
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CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
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CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
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"Tawny Townland, Co. Donegal". townlands.ie. Retrieved 27 August 2024. "CD154 - Donegal Population by Private Households, Occupied and Vacancy Rate"....
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from B7-CD28 and CD40–CD40L interactions. When CD40 on the APC binds CD40L(CD154) on the T cell, signals are sent back to both the APC and the T cell. (1)...
5 KB (637 words) - 09:45, 14 March 2022
CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
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MHC-antigen complex. It is followed by synthesis and presentation of CD40L (CD154) on the Th2 cell, which binds to CD40 on the B cell, thus the Th2 cell can...
16 KB (1,951 words) - 06:29, 22 August 2024
BAFF (CD257, TNFSF13B) CAML CD70 (CD27L, TNFSF7) CD153 (CD30L, TNFSF8) CD154 (CD40L, TNFSF5) Ectodysplasin (A, A2) FasL (CD95L, TNFSF6) GITRL (TNFSF18)...
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CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
43 KB (4,657 words) - 07:27, 28 November 2024
Activation of T cell immune response by T cell costimulation 5 CD40 ligand CD154, TRAP, Gp39, T-BAM CD40LG Regulation of adaptive immune response by activating...
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CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
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targets. Furthermore, type I NKT cells upregulate the costimulatory receptor CD154 (CD40 ligand), which, in conjunction with their cytokine production, potently...
13 KB (1,585 words) - 05:15, 24 September 2023
CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163...
13 KB (1,620 words) - 15:17, 9 December 2024