killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. In humans, the CD38 protein is encoded by the CD38 gene which...
35 KB (3,825 words) - 06:11, 5 June 2024
among others, is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally...
22 KB (1,823 words) - 07:01, 8 August 2024
CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38. In animal studies it boosts levels of nicotinamide...
3 KB (233 words) - 16:47, 29 April 2024
bronchitis (inflammation of the airways in the lungs). Isatuximab is an anti-CD38 mAb intended to treat relapsed or refractory multiple myeloma. It entered...
31 KB (3,186 words) - 02:41, 16 July 2024
vulnerable to extracellular degradation by CD38 enzyme, which can be inhibited by compounds such as CD38-IN-78c. NMN is found in fruits and vegetables...
18 KB (1,681 words) - 01:33, 28 June 2024
including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The most common adverse reactions include cytokine release...
12 KB (794 words) - 03:30, 2 September 2024
cells with the greatest self-renewal capacity and were shown to be CD34+ and CD38− cell fraction within the lineage-depleted cell population (LIn−). Human...
27 KB (3,084 words) - 01:44, 21 December 2023
cytoplasm and occasionally on the cell surface; myeloma cells are often CD56, CD38, CD138, and CD319 positive and CD19, CD20, and CD45 negative. Flow cytometry...
131 KB (13,504 words) - 07:52, 2 September 2024
much weaker catalyst than CD38. cADPR is required for regulation of Ca2+ in cells. Only CD38 hydrolyzed cADPR to ADPR. CD38 is widely expressed in tissues...
11 KB (1,302 words) - 13:41, 13 July 2024
NAD+ glycohydrolase (section CD38)
contain enzymes such as CD38 and SARM1 that consumes NAD+. CD38 is an enzyme that triggers inflammatory responses and type II CD38 contains an ecto-NADase...
8 KB (867 words) - 18:53, 5 May 2024
including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The US Food and Drug Administration (FDA) label prescribing...
14 KB (1,146 words) - 16:18, 2 September 2024
Sanchez, L; Wang, Y; Siegel, DS (2016). "Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma". J Hematol Oncol...
13 KB (1,661 words) - 22:18, 9 December 2023
marrow with an abnormal immunophenotype (CD38+ CD56+ CD19−) mixed in with cells of a normal phenotype (CD38+ CD56− CD19+); in MGUS, on average more than...
19 KB (2,182 words) - 00:14, 9 July 2024
Fradette JJ, Gibbons DL (December 2019). "The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid...
32 KB (3,346 words) - 01:19, 26 August 2024
Because of the ability to reduce disulfide bonds, DTT can be used to denature CD38 on red blood cells. DTT will also denature antigens in the Kell, Lutheran...
8 KB (872 words) - 01:49, 15 December 2023
Candidate genes include OXTR (polymorphisms in the oxytocin receptor), CD38, COMT, DRD4, DRD5, IGF2, AVPR1A and GABRB2. It is theorized that some of...
92 KB (10,851 words) - 04:02, 20 August 2024
and ADPR are synthesized from NAD+ by the bifunctional ectoenzymes of the CD38 family (also includes the GPI-anchored CD157 and the specific, monofunctional...
12 KB (1,183 words) - 14:06, 24 November 2023
ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor. ADPR...
5 KB (337 words) - 19:07, 25 March 2024
angiogenesis, and integrin activation. CD31 on endothelial cells binds to the CD38 receptor on natural killer cells for those cells to attach to the endothelium...
26 KB (3,115 words) - 18:11, 29 January 2024
population often express features of activated CD8+ T cells, such as CD29, CD38, HLA-DR, CD45RO and CD95. Expression of CD25 was on the other hand decreased...
11 KB (1,127 words) - 06:28, 10 February 2024
plasma antibodies, and positively correlated with degranulation of NK cells. CD38 on leukocytes attaching to CD16 on endothelial cells allows for leukocyte...
17 KB (1,844 words) - 08:01, 29 April 2024
dexamethasone (CyBorD) with daratumumab added. Daratumumab, a monoclonal antibody to CD38, a protein that is expressed on plasma cells, was approved in US and EU for...
16 KB (1,638 words) - 03:32, 26 August 2024
the biologist Graham J. Thompson and colleagues identified the genes OXTR, CD38, COMT, DRD4, DRD5, IGF2, GABRB2 as candidates "affecting altruism". The geneticist...
20 KB (2,090 words) - 21:09, 19 July 2024
million) expanding Roche's oncology pipeline. Tusk announced that the anti-CD38 antibody it is developing will be spun off to form a new company, Black Belt...
55 KB (5,124 words) - 05:32, 27 August 2024
like CD4 and CD135): LT-HSC: CD34−, CD38−, SCA-1+, Thy1.1+/lo, C-kit+, lin−, CD135−, Slamf1/CD150+ ST-HSC: CD34+, CD38+, SCA-1+, Thy1.1+/lo, C-kit+, lin−...
12 KB (1,400 words) - 12:27, 25 July 2024
factors, including MLL1 (KMT2A), C/EBPβ, and NF-κB. NF-κB and the enzyme CD38 are mutually activating. NF-κB is expressed as a result of inhibition of...
37 KB (4,194 words) - 10:43, 31 July 2024
CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e...
43 KB (4,651 words) - 13:41, 27 July 2024
cells, these cells express plasma cell markers such as CD79a, IR4, BLIMP1, CD38, and CD138. About 70% of PBL cases are EBV+, with most of the lymphoma cells...
140 KB (16,977 words) - 20:56, 2 September 2024
proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. In December 2020, selinexor was approved by the FDA...
30 KB (2,715 words) - 06:09, 16 July 2024
et al. (July 2015). "Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow". Immunity. 43 (1): 132–45. doi:10...
24 KB (2,793 words) - 18:41, 30 May 2024