CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. It is associated with agammaglobulinemia-6...
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Polatuzumab vedotin, sold under the brand name Polivy, is a CD79b-directed antibody-drug conjugate medication used for the treatment of diffuse large...
19 KB (1,312 words) - 15:36, 29 July 2024
Type OMIM Gene AGM1 601495 IGHM AGM2 613500 IGLL1 AGM3 613501 CD79A AGM4 613502 BLNK AGM5 613506 LRRC8A AGM6 612692 CD79B...
20 KB (1,955 words) - 03:32, 17 July 2024
CD79A and CD79B (also known as Igα and Igβ); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding. CD79a and CD79b are both...
7 KB (879 words) - 02:51, 17 April 2022
may refer to: B-29 Superfortress, an aircraft A human gene also known as CD79B Sicilian Defence, Encyclopaedia of Chess Openings code This disambiguation...
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transcription factors, some of which control cell proliferation. CD79A and CD79B: these genes' products are critical components of the B-cell receptor. Mutations...
69 KB (8,143 words) - 18:36, 22 January 2024
TNFAIP3, MYC, and/or BCL6 genes. PCNSL 90–100% III all Mutations in MYD88 and CD79B genes and copy number gains at the programmed death ligand 1 and programmed...
140 KB (16,977 words) - 20:56, 2 September 2024
heavy chains, which are normally linked to Ig-α (or CD79A) and Ig-β (or CD79B) signaling molecules. Each B cell, produced in the bone marrow, is highly...
18 KB (2,173 words) - 16:05, 30 November 2023
encoded by the CD79A gene. The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in...
20 KB (2,392 words) - 07:38, 23 August 2024
MGD010 is a therapy which targets the B-cell surface proteins CD32B and CD79B, and is indicated for lupus and rheumatoid arthritis. In 2015, Takeda sold...
33 KB (2,778 words) - 01:29, 7 September 2024
Splice-site mutations are recurrently found in key lymphoma genes like BCL7A or CD79B due to aberrant somatic hypermutation as the sequence targeted by AID overlaps...
14 KB (1,719 words) - 23:01, 31 March 2024
mouse CA-125 ovarian cancer (diagnosis) Iladatuzumab vedotin mab humanized CD79B cancer Imalumab mab human macrophage migration inhibitory factor (MIF) cancer...
136 KB (4,020 words) - 07:14, 15 August 2024
Antigen receptor accessory molecules CD3-γ, -δ and -ε chains CD79a and CD79b A further molecule is found on the surface of T cells that is also involved...
16 KB (847 words) - 10:57, 24 June 2024
surface. CD79B Also known as B-cell antigen receptor complex-associated protein beta chain, is a protein that in humans is encoded by the CD79B gene. Together...
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Libtayo – September 2018 – PD-1 Polatuzumab vedotin – Polivy – June 2019 – CD79B The bispecific antibodies have yielded promising results in clinical trials...
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diverse genes; 3) the overproduction of various cell-activating cytokines and CD79B (encoding the Ig-beta protein component of the B-cell receptor); 4) gene-inactivating...
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HGNC:1696 P21854 2538 CD74 HGNC:1697 P04233 2539 CD79A HGNC:1698 P11912 2540 CD79B HGNC:1699 P40259 2541 CD80 HGNC:1700 P33681 2542 CD81 HGNC:1701 P60033 2543...
277 KB (17 words) - 23:17, 27 April 2024
CD300C; CD300D; CD300E; CD300LB; CD300LF; CD300LG; CD33; CD3G; CD7; CD79A; CD79B; CD80; CD83; CD86; CD8A; CD8B; CD8B1; CD96; CEACAM1; CEACAM16; CEACAM19;...
5 KB (367 words) - 17:57, 28 July 2023
monoclonal B cells do not express CD5, CD23, CD10, or CD103 but strongly express CD79B and light chain Ig have been tentatively designated as having monoclonal...
33 KB (4,199 words) - 05:17, 3 December 2023
effects block apoptosis and thereby prolong cell survival. Mutations in the CD79B and CARD11 genes (rare cases) also lead to activation of the NF-kappa B...
22 KB (2,669 words) - 05:05, 4 January 2024
CD19 CD81 Inhibitory CD22 Accessory molecule (CD79) Ig-α (CD79A) Ig-β (CD79B) T cells Antigen receptor - T cell receptor (TCR) Subunits - TRA@ / TRB@...
38 KB (2,656 words) - 12:11, 30 October 2023
of the NF-κB signaling pathway and thereby prolong cell survival; 2) the CD79B gene (~50% of cases) which can lead to overactivation of B-cell receptor...
22 KB (2,625 words) - 15:15, 29 December 2023
(44% of cases) and CD79B (26% of cases) genes. The exact mutation seen in the MYD88 (i.e. L265P) and some or the mutations in CD79B occur in diverse types...
38 KB (4,735 words) - 06:59, 29 April 2024
CD81 Immunodeficiency, hypogammaglobulinemia, and reduced B cells; 612692; CD79B Immunodeficiency, isolated; 300584; IKBKG Immunodeficiency, X-linked, with...
234 KB (18,877 words) - 15:43, 9 May 2024
membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell...
7 KB (1,043 words) - 14:25, 3 December 2023
antigen receptor complex-associated protein alpha chain, CD79A, together with CD79B, forms the B-cell antigen receptor (BCR) by covalently associating with...
76 KB (6,550 words) - 16:19, 30 March 2024