Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. The protein encoded by this gene is a member of the E2F family of transcription...

transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are...

Additionally, the E2F1 transcription factor in the AD brain is found primarily in the cytoplasm rather than its normal location in the nucleus. E2F1 normally regulates...

regions of genes for cell proliferation or progression of the cell cycle. E2F1 to E2F5 are known to associate with proteins in the pRb-family of proteins...

is degraded via cyclin F to control H2A.X levels after genotoxic stress. E2F1, E2F2, and E2F3A are the three canonical activators of the E2F family of...

factor E2F1 is a potent and specific inhibitor of beta-catenin/T-cell factor (TCF)-dependent transcription, and that this function contributes to E2F1-induced...

Legesse-Miller A (August 2007). ""Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron". PLOS Genetics...

Pavletich NP (December 2005). "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release". Cell. 123 (6):...

alter the activity of many transcription factors, including ACTR, cMyb, E2F1, EKLF, FEN 1, GATA, HNF-4, HSP90, Ku70, NFκB, PCNA, p53, RB, Runx, SF1 Sp3...

specific TF according to literature or domain structure – No motif [170] E2F1 ENSG00000101412 E2F Known motif – High-throughput in vitro [171] WTTGGCGCCHWW...

HGNC:20908 Q86YF9 4653 DZIP1L HGNC:26551 Q8IYY4 4654 DZIP3 HGNC:30938 Q86Y13 4655 E2F1 HGNC:3113 Q01094 4656 E2F2 HGNC:3114 Q14209 4657 E2F3 HGNC:3115 O00716 4658...

Therefore, Rb remains associated with transcription factor E2F1, preventing transcription of E2F1 target genes which are crucial for the G1/S transition....

retinoblastoma (Rb) protein and induces the release of the transcription factor E2F1 which is necessary for DNA replication (Liu et al., 1998). The G1/S transition...

to the transcription factor E2F1, an important cell cycle regulator. This represses the transcriptional targets of E2F1, leading to cell cycle arrest...

transcription factor E2F1. This liberates E2F1 from its bound state in the cytoplasm and allows it to enter the nucleus. Once in the nucleus, E2F1 promotes the...

that is encoded by the GRAMD4 gene. GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis. GRCh38: Ensembl release 89: ENSG00000075240...

origin-specific cis-elements and several protein factors, including the Myb complex, E2F1, and E2F2. This combinatorial specification and multifactorial regulation...

transcription of genes by this mechanism. Examples include: ACTR, cMyb, E2F1, EKLF, FEN 1, GATA, HNF-4, HSP90, Ku70, MKP-1, NF-κB, PCNA, p53, RB, Runx...

cyclin family proteins: Cyclin D, Cyclin E transcriptional regulators: Myc, E2f1, p130 cyclin-dependent kinase inhibitors (CKIs): p27Kip1, p21, Wee1 centriole...

"PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells". Molecular Carcinogenesis. 48 (12): 1149–58....

DNA-dependent transcription regulation. NDN (gene) has been shown to interact with: E2F1, HNRNPU, IL1A, Low affinity nerve growth factor receptor, NUCB2, and P53...

Dick FA (March 2012). "DNA damage signals through differentially modified E2F1 molecules to induce apoptosis". Molecular and Cellular Biology. 32 (5): 900–12...

potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1". Journal of Molecular Medicine. 96 (6): 513–525. doi:10.1007/s00109-018-1636-7...

Maquis. Greenhill Books. http://www.raf.mod.uk/rafcms/mediafiles/9647CE1A_E2F1_FD48_EE58A77DCDE87EBE.pdf Archived 24 March 2009 at the Wayback Machine AP...

Overexpression of circFOXO3 and its downregulation binds to the transcription factors E2F1, HIF1α and protein ID1, FAK, causing cardiomyopathy induced by DOX. Titin...

homolog to yeast Tra1, has been shown to directly interact with c-Myc and E2F1, known oncoproteins. Rapid advance in cancer genomics and high-throughput...

Transcription factor Sp1 has been shown to interact with: AATF, CEBPB, COL1A1, E2F1, FOSL1, GABPA, HDAC1, HDAC2, HMGA1, HCFC1, HTT, KLF6, MEF2C, MEF2D, MSX1...

embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically...

regulated increase in E2F1-mediated transcription of E-selectin gene. Therefore, agents such as RRD-251 that can target activity of E2F1 may have potential...

transcription activator—when interacting with the cellular transcription factor, E2F1/DP1. E6 can also bind to PDZ-domains, short sequences which are often found...