Entry inhibitors, also known as fusion inhibitors, are a class of antiviral drugs that prevent a virus from entering a cell, for example, by blocking...

places. Improved protease inhibitors are now in development. Protease inhibitors have also been seen in nature. A protease inhibitor was isolated from the...

inhibitors or INSTIs) as a "base". Entry inhibitors (or fusion inhibitors) interfere with binding, fusion and entry of HIV-1 to the host cell by blocking...

Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert and Michael Ruff, a US neuroscientist and immunologist. Peptide T, and its modified...

that disrupt fusion of virus and target cell are termed entry inhibitors or fusion inhibitors.[citation needed] HIV binds to the host CD4+ cell receptor...

Simplex Entry inhibitor Dolutegravir HIV Integrase inhibitor Doravirine (Pifeltro) HIV NNRTI Edoxudine Herpes Simplex Thymidine analogue inhibitor Efavirenz...

transcriptase inhibitor and an integrase inhibitor, and was further used in 2011 by a team of researchers combining an integrase inhibitor with a CCR5 entry inhibitor...

in safety between the maraviroc and placebo groups. Maraviroc is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the...

Non-nucleoside reverse transcriptase inhibitors (NNRTIs): delavirdine (brand name Rescriptor, no longer available) Attachment inhibitors fostemsavir (brand name Rukobia)...

causes AIDS, enters cells. Hence antagonists of this receptor are entry inhibitors and have potential therapeutic applications in the treatment of HIV...

catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with the enzyme such...

the surface of a CD4 cell. Post-attachment inhibitors are a subclass of HIV drugs called entry inhibitors. On March 6, 2018, the U.S. Food and Drug Administration...

remained susceptible to all the entry inhibitors. Furthermore, HIV isolates that do not require the CD4 receptor for cell entry were also susceptible to fostemsavir...

preclinical studies of immune competent mice CCR5 inhibitors blocked metastasis to the bones and brain. CCR5 inhibitors also reduce the infiltration of tumor associated...

Hope', Los Angeles Times, 20 June 1993 Reeves JD, Derdeyn CA (2007). Entry Inhibitors in HIV Therapy. Springer Science & Business Media. p. 179. ISBN 9783764377830...

endogenous – endoscopy – endotoxin – endpoint – enteric – enteritis – entry inhibitors – Env – envelope – enzyme – enzyme-linked immunosorbent assay (ELISA)...

co-receptor without interfering with its natural activity. Unlike other entry inhibitors, PRO 140 is a monoclonal antibody. The mechanism of inhibition is competitive...

chlorphenamine; protease inhibitors: indinavir, ritonavir, saquinavir, nelfinavir; non-nucleoside reverse-transcriptase inhibitors (antiretroviral drugs):...

Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are prescribed typically to people who are at high risk...

mechanism led to the development of a class of HIV medicines, the entry inhibitors. The presence of this mutation, however, is not a unifying theme among...

resistance mutations can effect the efficacy of these treatments as well. Entry inhibitors block the ability of HIV to enter its target cells. HIV must bind to...

to a class of drugs used to treat HIV, the chemokine antagonists or entry inhibitors, and helped (conceptually) in the advances that led to the discovery...

MBarek M, Warlich M, Lohse AW, Pollok JM, et al. (May 2013). "The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized...

natural inhibitors called "serpins" (abbreviated from serine protease inhibitors) can form a covalent bond with the serine protease, inhibiting its function...

Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). MMPs belong to a family of zinc-dependent neutral endopeptidases...

Reuptake inhibitors (RIs) are a type of reuptake modulators. It is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter...

combination of reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry inhibitors. Lenacapavir is approved for those who...

2013). "Development of oleanane-type triterpenes as a new class of HCV entry inhibitors". Journal of Medicinal Chemistry. 56 (11): 4300–4319. doi:10.1021/jm301910a...

PMID 22027647. O'Brien WA (July 31, 2001). "HIV entry—from molecular insights to specific inhibitors". Medscape HIV/AIDS Conference Coverage. Medscape...

Zhou, Yanchen; Simmons, Graham (October 2012). "Development of novel entry inhibitors targeting emerging viruses". Expert Review of Anti-infective Therapy...