• Thumbnail for Globotriaosylceramide
    Globotriaosylceramide is a globoside. It is also known as CD77, Gb3, GL3, and ceramide trihexoside. It is one of the few clusters of differentiation that...
    4 KB (379 words) - 15:37, 29 April 2024
  • Thumbnail for Shiga toxin
    toxin bind to a component of the cell membrane known as glycolipid globotriaosylceramide (Gb3). Binding of the subunit B to Gb3 causes induction of narrow...
    19 KB (2,259 words) - 00:57, 29 June 2024
  • Thumbnail for Globoside
    (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another important characteristic...
    5 KB (562 words) - 15:12, 17 April 2024
  • Thumbnail for Escherichia coli O157:H7
    needed] The digestive tract of cattle lack the Shiga toxin receptor globotriaosylceramide, and thus, these can be asymptomatic carriers of the bacterium....
    21 KB (2,182 words) - 05:36, 15 March 2024
  • In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.79) is an enzyme that catalyzes the chemical reaction...
    5 KB (394 words) - 18:24, 23 January 2024
  • endothelial injury in locations such as the kidney by binding to globotriaosylceramide (Gb3).[citation needed] Names of the group and its subgroups include...
    21 KB (2,276 words) - 02:40, 29 June 2024
  • Thumbnail for Fabry disease
    A, encoded by GLA) due to mutation causes a glycolipid known as globotriaosylceramide (abbreviated as Gb3, GL-3, or ceramide trihexoside) to accumulate...
    37 KB (3,878 words) - 18:31, 5 June 2024
  • Thumbnail for GLA (gene)
    for breaking down globotriaosylceramide, a fatty substance stored various types of cardiac and renal cells. When globotriaosylceramide is not properly catabolized...
    20 KB (1,978 words) - 07:05, 2 June 2024
  • Thumbnail for Sweat gland
    a lack of sweat glands. Fabry disease, characterized by excess globotriaosylceramide (GL3), causes a decrease in sweat gland function due to GL3 deposits...
    44 KB (4,608 words) - 07:32, 19 May 2024
  • Thumbnail for Migalastat
    α-GalA, which is responsible for breaking down the sphingolipid globotriaosylceramide (Gb3), among other glycolipids and glycoproteins. Some of these...
    16 KB (1,414 words) - 05:45, 13 April 2024
  • Thumbnail for Cerebroside
    corresponding defects for galactocerebrosides are: a) Ceramide trihexoside (globotriaosylceramide) accumulation – Fabry's disease. Clinical features include acroparaesthesia...
    6 KB (723 words) - 14:38, 6 December 2023
  • Thumbnail for Hemolytic–uremic syndrome
    symptoms seen with HUS. Shiga toxin gains entry to cells by binding to globotriaosylceramide (Gb3) which is a globoside found on cell membranes, it is found...
    55 KB (5,697 words) - 15:34, 15 January 2024
  • Thumbnail for GBGT1
    do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding...
    3 KB (339 words) - 11:25, 15 January 2024
  • comprehensive line of sphingolipids, glycosphingolipids, gangliosides, globotriaosylceramides, fatty acids, and sterols. Freed, Ben (5 June 2012). "Cayman Chemical...
    5 KB (495 words) - 15:51, 17 May 2024
  • may refer to: GB3 Championship, an open wheel motor racing series Globotriaosylceramide - It is also known as CD77, Gb3, and ceramide trihexoside Greater...
    633 bytes (108 words) - 13:34, 22 November 2021
  • EC 2.4.1.78: phosphopolyprenol glucosyltransferase EC 2.4.1.79: globotriaosylceramide 3-β-N-acetylgalactosaminyltransferase EC 2.4.1.80: ceramide glucosyltransferase...
    215 KB (21,664 words) - 23:41, 8 May 2024
  • Killen PD, Brady RO, Kulkarni A, and Shayman JA. Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation. J Clin Invest....
    21 KB (2,360 words) - 03:21, 24 May 2024
  • include Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, globotriaosylceramide/CD77 synthase, and histo-blood group Pk UDP-galactose. This enzyme...
    3 KB (276 words) - 18:23, 23 January 2024
  • "Separation and Analysis of Lactosylceramide, Galabiosylceramide, and Globotriaosylceramide by LC-MS/MS in Urine of Fabry Disease Patients". Analytical Chemistry...
    9 KB (846 words) - 05:01, 24 June 2024
  • Thumbnail for A4GALT
    catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group...
    5 KB (627 words) - 10:39, 24 January 2024
  • upon it, aiding transfer of galactose to lactosylceramide to form globotriaosylceramide. CDw17+antigen at the U.S. National Library of Medicine Medical...
    2 KB (174 words) - 07:42, 5 May 2024
  • asymptomatic bacteriuria. PapGI adhesins bind preferentially to globotriaosylceramide (GbO3), while the isoreceptors of PapGIV are unknown. E. coli carrying...
    9 KB (994 words) - 21:40, 11 January 2024
  • Thumbnail for Roscoe Brady
    Selden RF, Brady RO. Infusion of a-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease. Proc Natl Acad Sci USA 2000;...
    10 KB (1,155 words) - 16:20, 25 June 2024
  • Thumbnail for B3GALNT1
    cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase". J Biol Chem. 275 (51):...
    9 KB (1,179 words) - 00:58, 6 January 2024
  • Three-dimensional structure of the oligosaccharide terminus of globotriaosylceramide and isoglobotriaosylceramide in solution. A rotating-frame NOE study...
    7 KB (813 words) - 18:28, 19 May 2024
  • same as cholera toxin. The main receptor for the shiga toxin is globotriaosylceramide or Gb3. Shiga toxin is also brought to the golgi apparatus before...
    25 KB (2,916 words) - 14:03, 4 January 2024
  • Thumbnail for Robert J. Desnick
    pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease. Mol. Ther. 18:23–33, 2010...
    35 KB (3,726 words) - 21:03, 9 June 2024
  • Thumbnail for Function-spacer-lipid Kode construct
    Stephen; Lingwood, Clifford A; Branch, Donald R (2010). "A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms". Glycobiology...
    41 KB (3,722 words) - 18:42, 13 March 2024