In cell biology, microsomes are heterogeneous vesicle-like artifacts (~20-200 nm diameter) re-formed from pieces of the endoplasmic reticulum (ER) when...
11 KB (1,551 words) - 02:54, 2 July 2023
CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes". Drug Metabolism and Disposition. 30 (7): 853–8. doi:10.1124/dmd.30.7...
118 KB (11,372 words) - 21:46, 17 August 2024
became apparent. To some of the participants, "microsomes" mean the ribonucleoprotein particles of the microsome fraction contaminated by other protein and...
65 KB (7,268 words) - 09:16, 29 July 2024
"Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes". Drug Metabolism and Disposition. 33 (4): 500–507. doi:10.1124/dmd.104...
42 KB (3,631 words) - 13:44, 27 July 2024
for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test". Mutation Research. 31 (6): 347–364. doi:10.1016/0165-1161(75)90046-1...
70 KB (8,162 words) - 00:40, 13 August 2024
for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test". Mutation Research/Environmental Mutagenesis and Related...
15 KB (1,872 words) - 05:19, 14 February 2024
adverse events, tolerance, rebound insomnia, and daytime alertness. Microsome studies indicate zolpidem is metabolized by CYP3A4 (61%) CYP2C9 (22%)...
58 KB (5,833 words) - 08:06, 5 July 2024
8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes". Drug Metabolism and Disposition. 32 (2): 272–279. doi:10.1124/dmd.32...
122 KB (12,800 words) - 06:07, 17 August 2024
with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl] acetoxyacetic...
7 KB (445 words) - 15:09, 7 November 2023
membrane anchor fixes the proteins into the endoplasmic reticulum (ER) and microsome membrane. COX is a common target for anti-inflammatory drugs. The most...
16 KB (1,779 words) - 11:08, 3 July 2024
neurotransmitters; the synthesis and catabolism of tyrosine; and the metabolism of microsomes. In nonenzymatic functions it acts as a reducing agent, donating electrons...
145 KB (15,124 words) - 11:17, 19 August 2024
metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation...
47 KB (4,108 words) - 05:59, 15 August 2024
testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes". Archives of Biochemistry and Biophysics. 346 (1): 161–169. doi:10.1006/abbi...
123 KB (11,581 words) - 15:07, 12 August 2024
activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2...
6 KB (445 words) - 21:54, 2 February 2024
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes". Drug Metabolism and Disposition. 30 (8): 904–910. doi:10.1124/dmd.30...
5 KB (356 words) - 13:33, 25 December 2023
enzyme CYP3A4 is the main enzyme in its phase 1 metabolism in human liver microsomes. Flunitrazepam is classed as a nitro-benzodiazepine. It is the fluorinated...
38 KB (3,723 words) - 15:02, 16 August 2024
mutagens. Mortelmans K, Zeiger E (November 2000). "The Ames Salmonella/microsome mutagenicity assay". Mutation Research. 455 (1–2): 29–60. doi:10...
19 KB (2,357 words) - 04:10, 8 November 2023
A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. doi:10.1016/0006-2952(75)90094-5...
31 KB (3,161 words) - 11:44, 26 July 2024
variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes". Pharmacogenetics. 14 (4): 225–238. doi:10.1097/00008571-200404000-00002...
134 KB (12,273 words) - 09:55, 19 August 2024
(November 2022). "High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach"...
87 KB (7,810 words) - 06:35, 18 August 2024
specific to autoimmune hepatitis are the antibodies against liver kidney microsome 1 (LKM1) and soluble liver antigen (SLA). Autoimmune hepatitis can also...
164 KB (16,800 words) - 16:49, 13 May 2024
mutagenicity and ethidium bromide mutagenicity in the Salmonella/mammalian microsome reverse mutation assay (Ames test)". Mutation Research. 439 (1): 37–47...
6 KB (602 words) - 03:40, 29 July 2024
CBD mediates a decrease in clobazam metabolism. Work with human liver microsomes shows that cannabidiol inhibits CYP3A5 and CYP3A4 to some degree. In vitro...
123 KB (11,363 words) - 09:03, 21 August 2024
urine. These metabolites are also found after oxidation with rat hepatic microsomes in vitro. The C-hydroxylated metabolites may be considered as the detoxification...
22 KB (2,709 words) - 22:48, 13 August 2024
biochemical reactions producing peroxides or phenols. Ampyrone stimulates liver microsomes and is also used to measure extracellular water. PubChem (25 March 2005)...
3 KB (103 words) - 09:15, 15 July 2024
Al-Zoughool M., Talaska, G. (2006). "4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the...
7 KB (544 words) - 13:50, 5 June 2024
5'-tetrachlorobiphenyl (PCB 52) and 3,3',4,4'-tetrachlorobiphenyl (PCB 77) by liver microsomes from four species of sea turtles". Chemical Research in Toxicology. 24...
133 KB (14,664 words) - 06:41, 19 August 2024
fatty acids on the delta 5, delta 6 and delta 9 desaturases of rat liver microsomes in vivo". Acta Biologica et Medica Germanica. 40 (12): 1699–1705. PMID 7345825...
130 KB (15,210 words) - 17:48, 3 August 2024
minutes in a suitable medium; this fraction contains cytosol and microsomes." The microsomes component of the S9 fraction contain cytochrome P450 isoforms...
4 KB (472 words) - 17:29, 16 May 2021
membrane-bound enzyme required for electron transfer to cytochrome P450 in the microsome of the eukaryotic cell from a FAD- and FMN-containing enzyme NADPH:cytochrome...
32 KB (3,618 words) - 16:03, 7 July 2024