RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes...
27 KB (3,099 words) - 15:01, 25 June 2024
MRNA vaccine (redirect from Rna vaccine)
mice. The following year self-amplifying mRNA was developed by including both a viral antigen and replicase encoding gene. The method was used in mice...
77 KB (7,879 words) - 16:49, 14 July 2024
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
65 KB (7,606 words) - 20:16, 12 August 2024
The RNA world is a hypothetical stage in the evolutionary history of life on Earth, in which self-replicating RNA molecules proliferated before the evolution...
92 KB (10,692 words) - 14:18, 22 July 2024
Defective interfering particle (redirect from Defective Interfering RNA)
something particularly prevalent in RNA viruses over DNA viruses due to the enzyme used (replicase, or RNA-dependent RNA polymerase.) DI genomes typically...
23 KB (2,726 words) - 23:34, 11 April 2024
Spiegelman's Monster (category RNA)
RNA chain of only 218 nucleotides that is able to be reproduced by the RNA replication enzyme RNA-dependent RNA polymerase, also called RNA replicase...
4 KB (558 words) - 01:22, 19 February 2024
replicate viral RNA molecules (reverse transcriptases and RNA replicases) lack molecular proofreading (3′ to 5′ exonuclease) activity, and that RNA sequences...
41 KB (4,630 words) - 14:14, 22 July 2024
Orthornavirae (redirect from RNA viruses)
viral enzyme RNA-dependent RNA polymerase (RdRp), also called RNA replicase. Positive-strand RNA viruses have genomes that can function as mRNA, so transcription...
31 KB (3,249 words) - 07:08, 27 July 2024
Ribozyme (redirect from Catalytic RNA)
properties of RNA". Visser CM (1984). "Evolution of biocatalysis 1. Possible pre-genetic-code RNA catalysts which are their own replicase". Origins of...
42 KB (5,174 words) - 14:16, 22 July 2024
Tobacco mosaic virus (category CS1 German-language sources (de))
codon. The 4 genes encode a replicase (with methyltransferase [MT] and RNA helicase [Hel] domains), an RNA-dependent RNA polymerase, a so-called movement...
34 KB (3,961 words) - 14:50, 4 August 2024
Bacteriophage (redirect from RNA phage)
translating viral mRNA into protein. For RNA-based phages, RNA replicase is synthesized early in the process. Proteins modify the bacterial RNA polymerase so...
79 KB (8,392 words) - 23:59, 14 August 2024
Coronavirus (redirect from Replicase-transcriptase complex)
to form a multi-protein replicase-transcriptase complex (RTC). The main replicase-transcriptase protein is the RNA-dependent RNA polymerase (RdRp). It is...
96 KB (10,573 words) - 23:32, 23 July 2024
Bacteriophage AP205 (section Replicase gene)
final ORF encodes the replicase gene. The protein product of this sequence yields a RNA-dependent RNA polymerase. The replicase gene is controlled by...
33 KB (4,020 words) - 09:31, 18 June 2024
genetic material is single-stranded or double-stranded. All RNA viruses use their own RNA replicase enzymes to create copies of their genomes.: 79 Reverse...
155 KB (18,249 words) - 08:24, 18 August 2024
transcriptase and replicase functions, the viral L protein is also thought to have an endonuclease activity that cleaves cellular messenger RNAs (mRNAs) for the...
46 KB (5,262 words) - 11:11, 10 June 2024
three accessory proteinases which are mainly involved in expressing the replicase gene. These proteinases are also responsible for activating or inactivating...
9 KB (895 words) - 19:57, 26 March 2024
Telomerase (section Small interfering RNA (siRNA))
shares common features with retroviral reverse transcriptases, viral RNA replicases and bacteriophage B-family DNA polymerases. TERT proteins from many...
49 KB (5,644 words) - 06:05, 27 April 2024
the viral RNA polymerase (Replicase) via a complementary −ssRNA as a template and translated as a separate short mRNA. This short subgenomic RNA is additionally...
15 KB (1,706 words) - 16:49, 4 July 2024
Abiogenesis (section The RNA world)
presence of various terrestrial minerals. RNA replicase can function as both code and catalyst for further RNA replication, i.e. it can be autocatalytic...
203 KB (21,024 words) - 04:27, 20 August 2024
Virusoid (redirect from Circular satellite RNAs)
Alternatively, the siRNAs and microRNAs generated during viral infections may have been amplified by helper virus replicases, whereby these molecules...
23 KB (2,615 words) - 17:40, 14 May 2024
the conversion of the negative-sense RNA genome into mRNA to be translated into viral proteins. As a replicase, the protein complex is responsible for...
21 KB (2,732 words) - 14:19, 11 April 2024
either RNA or DNA genomes) that encode an RNA-dependent DNA polymerase. RNA-dependent RNA polymerase (RdRp), also called RNA replicase, produces RNA (ribonucleic...
30 KB (3,483 words) - 03:44, 12 May 2024
Remdesivir (category Anti–RNA virus drugs)
presumably in other cells as well. Mutations in the mouse hepatitis virus RNA replicase that cause partial resistance to remdesivir were identified in 2018...
113 KB (9,807 words) - 01:49, 16 July 2024
David Baltimore (section MicroRNA Research)
its effect on cell metabolism, including the first description of an RNA replicase. After his PhD, Baltimore returned to MIT for postdoctoral research...
80 KB (8,318 words) - 22:42, 15 August 2024
DNA sequencing (section RNA sequencing)
"Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene". Nature. 260 (5551): 500–7. Bibcode:1976Natur...
129 KB (14,415 words) - 11:32, 5 August 2024
Timeline of the history of genetics (category CS1 German-language sources (de))
"Complete nucleotide-sequence of bacteriophage MS2-RNA - primary and secondary structure of replicase gene". Nature. 260 (5551): 500–507. Bibcode:1976Natur...
41 KB (4,882 words) - 16:57, 12 June 2024
Gene silencing (category RNA)
RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides in length. The fragments integrate into a multi-subunit protein called the RNA-induced...
48 KB (5,609 words) - 16:25, 22 May 2024
structure of β-CoV genome is similar to that of other CoVs, with an ORF1ab replicase polyprotein (rep, pp1ab) preceding other elements. This polyprotein is...
15 KB (1,479 words) - 01:17, 9 March 2024
The internal structure of MRV has been fully reconstructed. λ3 is the RNA replicase, whereas μ2 is a transcription factor. As stated in the beginning of...
19 KB (2,242 words) - 16:27, 22 June 2024
interact are rep and PVR proteins which are replicase polyprotein 1ab and Poliovirus receptor respectively. Replicase polyprotein 1ab protein is in the human...
18 KB (1,838 words) - 09:45, 6 January 2024