by Crocker revealed homology to CD22 (Siglec-2), CD33 (Siglec-3) and myelin-associated glycoprotein (MAG/Siglec-4), leading to the proposal for a family...

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage...

of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone...

Vadastuximab talirine is an antibody-drug conjugate (ADC) directed to CD33 (siglec-3) which is a transmembrane receptor expressed on cells of myeloid lineage...

Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of macrophages. It is found in especially high amounts on macrophages of the spleen...

that binds to CD23; dacetuzumab, a monoclonal antibody that binds CD40; Siglec-3 a monoclonal antibody that binds CD33; blinatumomab, a monoclonal antibody...

PROM1 (CD133) ALCAM (CD166) ITGB1 (CD29) TNFRSF8 (CD30) PECAM-1 (CD31) Siglec-3 (CD33) CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants...

They found that 9 of the 12 marketed Siglec-Fc reagents bind to HeLa cells, and two of which, Siglec-11 and Siglec-14, had binding that was vulnerable...

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts...

sixth member of the SIGLEC family of receptors to be identified. The protein has also been given the CD designation CD327. Siglec-6 was first found to...

lectin 12, or Siglec-XII, is a protein that in humans, is encoded by the SIGLEC12 gene. Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family...

Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem...

the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor...

doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed...

Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte...

TCRs, BCRs and FcRs. Subsequently, phospholipase Cy and phosphatidylinositol 3-kinase (PLCy and PI3-K) are activated, together leading to the production...

inhibitory receptor Siglec-11, but induces an opposing response through interactions with the paired activating receptor Siglec-16, exemplifying the...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

MedlinePlus Overview bonecancer Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer...

immunoreceptor signaling". Current Opinion in Immunology. 13 (3): 299–306. doi:10.1016/S0952-7915(00)00219-3. PMID 11406361. Nika K, Soldani C, Salek M, Paster W...

AP; Rasmussen, HS; Rothenberg, ME; Hirano, I (22 October 2020). "Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis". The New England Journal...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563. Angata T, Varki A (2000). "Cloning, characterization, and phylogenetic analysis of siglec-9...

generally show decreased expression of surface CD7, CD161, NKp30, NKp46, and SIGLEC-7 but demonstrate retained or even higher expression of CD2, CD57, and CD85j...

mammalian glycan-binding proteins (GBPs): C-type lectin, galectin, and SIGLEC immune receptors that bind carbohydrates: CD1, T cell receptor, and anti-carbohydrate...

PMID 17380156. S2CID 26722878. Macauley MS, Crocker PR, Paulson JC (October 2014). "Siglec-mediated regulation of immune cell function in disease". Nature Reviews...

these osteoblasts can worsen tumors in two ways. First, they can induce SiglecFhigh-expressing neutrophil formation that in turn promotes lung tumor growth...

collaboration with bluebird bio, hands over $25M sweetener". FierceBiotech. 3 June 2015. Retrieved 2015-10-28. "UCI scientists identify a new approach for...

(December 2017). "Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils". Science. 358 (6367): eaal5081. doi:10.1126/science.aal5081...

SCN10A SCN1B SCN2B SCN3A SCN3B SCN4B SCN7A SCN8A SCNN1A SCNN1B SCNN1D SCNN1G SIGLEC SK3 SK channel Saffman–Delbrück model Sammy Lee (scientist) Sarcolemma Sarcomere...