• Thumbnail for TRPA1
    ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the TRPA1 (and in mice and rats by the Trpa1) gene. TRPA1 is an ion...
    35 KB (4,048 words) - 22:58, 16 July 2024
  • Thumbnail for Umbellulone
    Umbellulone (section TRPA1)
    hypothesized to cause headaches by influencing the trigeminovascular system via TRPA1. Umbellularia californica is a tree native to California and Southern Oregon...
    12 KB (1,208 words) - 20:59, 14 November 2023
  • Thumbnail for Tetrahydrocannabiorcol
    it is significantly more potent than THC or THCV as an activator of the TRPA1 calcium channel which plays an important role in pain perception, and it...
    4 KB (331 words) - 17:27, 8 June 2024
  • Thumbnail for Allyl isothiocyanate
    This pungency and the lachrymatory effect of AITC are mediated through the TRPA1 and TRPV1 ion channels. It is slightly soluble in water, but more soluble...
    10 KB (842 words) - 02:08, 15 August 2024
  • Thumbnail for Wasabi receptor toxin
    WaTx targets TRPA1, also known as the wasabi receptor or irritant receptor. WaTx is a cell-penetrating toxin that stabilizes the TRPA1 channel open state...
    17 KB (1,980 words) - 19:51, 28 November 2023
  • Thumbnail for Cannabichromene
    though in vivo effects have not been demonstrated. CBC acts on the TRPV1 and TRPA1 receptors, interfering with their ability to break down endocannabinoids...
    9 KB (735 words) - 02:10, 15 August 2024
  • Thumbnail for Wasabi
    The sensory neural target of mustard oil is the chemosensory receptor, TRPA1, also known as the wasabi receptor. The unique flavour of wasabi is a result...
    34 KB (3,037 words) - 05:06, 2 September 2024
  • Thumbnail for Thermoreceptor
    Channels shown: TRPA1, TRPM8, TRPV4, TRPV3, TRPV1, TRPM3, ANO1, TRPV2...
    10 KB (1,263 words) - 06:25, 2 January 2024
  • of waterwitch. Like TRPA1 and other TRP channels, these function as ion channels in a number of sensory systems. TRPA- or TRPA1-like channels also exists...
    49 KB (5,517 words) - 22:16, 16 July 2024
  • Thumbnail for TRPA (ion channel)
    family is made up of 7 subfamilies: TRPA1, TRPA- or TRPA1-like, TRPA5, painless, pyrexia, waterwitch, and HsTRPA. TRPA1 is the only subfamily widely expressed...
    8 KB (809 words) - 23:04, 16 July 2024
  • Thumbnail for Tear gas
    associated with the exposure to tear gas are often require medical attention. TRPA1 ion channels expressed on nociceptors have been implicated as the site of...
    34 KB (3,498 words) - 07:01, 26 June 2024
  • potently activates TRPA1. In a subsequent study, she demonstrated that compounds found in garlic plants, allicin and DADs, also activate TRPA1. Interestingly...
    8 KB (893 words) - 07:45, 17 November 2023
  • Thumbnail for HC-030031
    HC-030031 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects. Eid SR, Crown...
    3 KB (214 words) - 11:47, 31 October 2023
  • Thumbnail for TRPV1
    (nociception). In primary afferent sensory neurons, it cooperates with TRPA1 (a chemical irritant receptor) to mediate the detection of noxious environmental...
    57 KB (6,738 words) - 09:20, 7 August 2024
  • sodium channels and the nociceptor cation channel TRPA1. Due to its unique ability to bind to TRPA1, Protoxin-I has been implicated as a valuable pharmacological...
    16 KB (1,797 words) - 03:30, 2 May 2024
  • Thumbnail for CS gas
    professionals and police. In addition, repeated exposure may cause sensitisation. TRPA1 (Transient Receptor Potential-Ankyrin 1) ion channel expressed on nociceptors...
    20 KB (1,959 words) - 22:08, 18 July 2024
  • Thumbnail for Tetrahydrocannabinolic acid
    DGLα, and an inhibitor of anandamide transport, as well as an agonist of TRPA1 and TRPV2. Many THCA reagents used in biochemistry experiments are contaminated...
    15 KB (1,623 words) - 23:19, 24 March 2024
  • Thumbnail for Dimethyl sulfoxide
    taste upon skin contact with DMSO may be due to nonolfactory activation of TRPA1 receptors in trigeminal ganglia. Unlike dimethyl and diallyl disulfides...
    38 KB (3,969 words) - 08:47, 2 September 2024
  • Thumbnail for ASP-7663
    activator of the TRPA1 channel. It has protective effects on cardiac tissue, and is used for research into the function of the TRPA1 receptor. JT-010...
    2 KB (139 words) - 21:29, 24 October 2021
  • Thumbnail for Cinnamon challenge
    vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers"...
    16 KB (1,417 words) - 01:01, 1 September 2024
  • Thumbnail for Mustard oil
    isothiocyanate. The pungency of allyl isothiocyanate is due to the activation of the TRPA1 ion channel in sensory neurons. White mustard (Brassica hirta) does not...
    9 KB (977 words) - 11:23, 10 August 2024
  • atoms, for example, in the fluorination reagent F-TEDA-BF4. Nucleophile TRPA1, the sensory neural target for electrophilic irritants in mammals. "Nucleophiles...
    19 KB (2,321 words) - 12:01, 2 March 2024
  • Thumbnail for Phenacyl chloride
    five deaths, which have resulted from pulmonary injury and/or asphyxia. TRPA1 (Transient Receptor Potential-Ankyrin 1) ion channel expressed on nociceptors...
    7 KB (613 words) - 17:11, 3 August 2024
  • Thumbnail for PF-4840154
    TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel...
    4 KB (307 words) - 20:00, 20 December 2023
  • Thumbnail for Garlic
    SunWook; Patapoutian, Ardem (2005). "The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin" (PDF). Current Biology. 15 (10) (published...
    60 KB (6,729 words) - 15:46, 31 August 2024
  • Thumbnail for Tramadol
    acetylcholine receptor antagonist NMDA receptor antagonist (very weak) TRPA1 inhibitor Tramadol acts on the opioid receptors through its major active...
    97 KB (9,171 words) - 21:16, 28 August 2024
  • the heat/capsaicin receptor TRPV1 and the irritant/wasabi receptor TRPA1. TRPA1 channels stimulated by lipopolysaccharide (LPS) may also cause acute...
    18 KB (1,956 words) - 09:20, 11 April 2024
  • Thumbnail for Cinnamaldehyde
    vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers"...
    20 KB (1,911 words) - 19:30, 29 July 2024
  • Thumbnail for CR gas
    lachrymatory agent (LA), exerting its effects through activation of the TRPA1 channel. Its effects are approximately 6 to 10 times more powerful than...
    14 KB (1,529 words) - 13:17, 3 September 2024
  • Thumbnail for JT-010
    a chemical compound which acts as a potent, selective activator of the TRPA1 channel, and has been used to study the role of this receptor in the perception...
    3 KB (244 words) - 18:06, 29 January 2023