inhibitors. Temsirolimus' high level of specificity for mTOR likely contributes to the tolerability of temsirolimus. However, temsirolimus increases mortality...
12 KB (1,180 words) - 22:17, 10 February 2024
MTOR inhibitors (section Temsirolimus)
everolimus (RAD001), and temsirolimus (CCI-779), are the newly developed rapamycin analogs. The rapamycin analog temsirolimus (CCI-779) is also a noncytotoxic...
57 KB (6,278 words) - 05:05, 3 June 2024
clear-cell carcinoma; cytokine therapy (IL-2, interferon), kinase inhibitors (temsirolimus, sunitinib, sorafenib, pazopanib) and anti-angiogenic therapies (bevacizumab)...
3 KB (333 words) - 01:07, 3 December 2023
the use of alternate dosing regimens or analogs such as everolimus or temsirolimus. Lung toxicity is a serious complication associated with sirolimus therapy...
69 KB (6,838 words) - 05:11, 22 June 2024
There is a phase I/II study at the Mayo Clinic of sorafenib and CCI-779 (temsirolimus) for recurrent glioblastoma. A study performed in 2008 showed that sorafenib...
31 KB (2,617 words) - 15:26, 6 April 2024
two primary mTOR inhibitors used in the treatment of human cancers, temsirolimus and everolimus. mTOR inhibitors have found use in the treatment of a...
119 KB (12,654 words) - 16:07, 28 May 2024
development of anti-cancer drugs such as erlotinib, nab-paclitaxel and temsirolimus, and the development of patient-derived tumor xenograft models. Hidalgo...
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treatment of Alzheimer's disease and bevacizumab, sorafenib, sunitinib and temsirolimus for renal cell carcinoma. All these are drugs with a high cost per treatment...
42 KB (4,888 words) - 15:37, 26 June 2024
Phase 2b study (TARGET trial) in non-small-cell lung carcinoma (NSCLC). Temsirolimus (Torisel) Everolimus (Afinitor) Vemurafenib (Zelboraf) Trametinib (Mekinist)...
20 KB (2,197 words) - 05:50, 29 November 2023
Cabozantinib Everolimus Lenvatinib Pazopanib Bevacizumab Sorafenib Tivozanib Temsirolimus Interleukin-2 (IL-2) has produced "durable remissions" in a small number...
100 KB (10,894 words) - 00:55, 11 July 2024
IL-1 receptor antagonists Anakinra mTOR Everolimus Ridaforolimus Sirolimus Temsirolimus Umirolimus Zotarolimus...
7 KB (299 words) - 13:45, 27 April 2024
wound healing (uncommon), anaphylaxis (rare) and angiooedema (rare). Temsirolimus IV mTOR inhibitor. Renal cell cancer and mantle cell lymphoma. Infusion...
52 KB (708 words) - 00:21, 11 April 2024
vindesine, imatinib, irinotecan, sorafenib, sunitinib, vemurafenib, temsirolimus, anastrozole, gefitinib; azole antifungals: ketoconazole itraconazole...
80 KB (7,810 words) - 23:14, 9 July 2024
signaling by targeting multiple receptor tyrosine kinase. Everolimus and temsirolimus are used in deregulating the mTOR pathway. Specifically, mTOR inhibitors...
38 KB (3,726 words) - 20:03, 27 October 2023
IL-2 (Denileukin diftitox) mTOR inhibitors Everolimus Ridaforolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib Vismodegib CDK inhibitors Abemaciclib...
12 KB (760 words) - 05:52, 10 June 2024
the only psychotropic drug that shows no effect on REM sleep. Torisel (temsirolimus): a drug approved for the treatment of Renal Cell Carcinoma (a type of...
33 KB (3,614 words) - 15:01, 18 June 2024
options in this setting are pazopanib (Votrient), sorafenib (Nexavar), temsirolimus (Torisel), interleukin-2 (Proleukin), everolimus (Afinitor), bevacizumab...
36 KB (3,400 words) - 05:06, 1 July 2024
Selumetinib L01EF01 Palbociclib L01EF02 Ribociclib L01EF03 Abemaciclib L01EG01 Temsirolimus L01EG02 Everolimus L01EG03 Ridaforolimus L01EG04 Sirolimus L01EH01 Lapatinib...
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effect against developing cancer, but may improve overall survival. Temsirolimus, an mTOR inhibitor, is under investigation as a potential treatment....
105 KB (10,821 words) - 02:34, 12 July 2024
and/or progression of many cancers including some thymus gland cancers.) Temsirolimus, a specific inhibitor of mTOR, mimicked the action of dimethyl itaconate...
95 KB (11,779 words) - 04:23, 6 July 2024
approved by the FDA. The mTOR inhibitor rapamycin analogs everolimus and temsirolimus or VEGF monoclonal antibody bevacizumab may also be an option. Since...
27 KB (3,282 words) - 18:16, 8 June 2024
generation inhibitors of mTOR. These other inhibitors include everolimus and temsirolimus. Compared with the parent compound rapamycin, everolimus is more selective...
69 KB (7,803 words) - 11:01, 11 April 2024
cyclolinopeptide B 193139-41-2 C56H85N17O12 kallidin 342-10-9 C56H87NO16 temsirolimus 162635-04-3 C56H87NO20 sitakisoside IV 163633-31-6 C56H92O29 digitonin...
47 KB (16 words) - 08:43, 18 August 2022
Cancer" at ClinicalTrials.gov Clinical trial number NCT01016015 for "Temsirolimus and Cixutumumab in Treating Patients With Locally Advanced, Metastatic...
6 KB (617 words) - 14:25, 9 May 2024
IL-2 (Denileukin diftitox) mTOR inhibitors Everolimus Ridaforolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib Vismodegib CDK inhibitors Abemaciclib...
12 KB (758 words) - 23:46, 14 March 2024
involved in many cancers and may be involved in epithelioid sarcoma. Temsirolimus is a tyrosine kinase inhibitor that blocks the effects of the mTOR protein...
52 KB (5,913 words) - 20:45, 30 May 2024
Bcl-2-family member protein Bak. mTOR inhibitors :[citation needed] Everolimus Temsirolimus mTOR is a kinase enzyme inside the cell that regulates cell growth, proliferation...
20 KB (2,453 words) - 10:36, 1 June 2024
(Schering) temodox (INN) temoporfin (INN) Temovate temozolomide (INN) temsirolimus (USAN) temurtide (INN) Ten-K Tenake tenamfetamine (INN) Tenathan tenatumomab...
14 KB (664 words) - 04:37, 2 July 2024
Inhibitors: Rapalogs: Everolimus Ridaforolimus Sirolimus (Rapamycin) Temsirolimus Umirolimus Zotarolimus; ATP-competitive / indirect: Berberine Curcumin...
14 KB (825 words) - 20:42, 9 February 2024
Huang KH (February 2020). "The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma"...
20 KB (2,347 words) - 23:01, 27 March 2024