U.S. Route 4 (US 4) is a 253-mile-long (407 km) United States Numbered Highway that runs from East Greenbush, New York, in the west to Portsmouth, New...

United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide...

U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

three-digit highway, it is still considered part of the double-digit U.S. Highway System. US 412 overlaps with U.S. 43, U.S. 56, US 60, U.S. 62, U.S. 63, U.S. 64...

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 30 or U.S. Highway 30 (US 30) is an east–west main route of the United States Numbered Highway System, with the highway traveling across the...

U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S...

U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four...

U.S. Route 191 (US 191) is a north–south highway in the Western United States and a spur of parent route U.S. Route 91 that has two segments. The southern...

U.S. Route 491 (US 491) is a north–south U.S. Highway serving the Four Corners region of the United States. It was created in 2003 as a renumbering of...

U.S. Route 99 (US 99) was a main north–south United States Numbered Highway on the West Coast of the United States until 1964, running from Calexico,...

U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is...

U.S. Highway 18 (US 18) is an east–west United States Numbered Highway in the Midwestern United States. The western terminus is in Orin, Wyoming, at an...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

"north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each...

U.S. Route 271 (US 271, US-271) is a north–south United States highway. Never a long highway, it went from bi-state route (Arkansas and Oklahoma) to a...

U.S. Route 10 or U.S. Highway 10 (US 10) is an east–west United States Numbered Highway located in the Midwest and Great Lakes regions of the U.S. Despite...

U.S. Route 275 (US 275) is a north–south United States highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The...

U.S. Route 276 (US 276) is a United States highway that runs for 106.4 miles (171.2 km) from Mauldin, South Carolina to Cove Creek, North Carolina. It...

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route...

U.S. Route 2 or U.S. Highway 2 (US 2) is an east–west United States Numbered Highway spanning 2,571 miles (4,138 km) across the northern continental United...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66), is a major east–west United...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England...

U.S. Route 80 or U.S. Highway 80 (US 80) is a major east–west United States Numbered Highway in the Southern United States, much of which was once part...

U.S. Route 550 (US 550) is a spur of U.S. Highway 50 that runs from Bernalillo, New Mexico to Montrose, Colorado in the western United States. The section...