U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

Several special routes of U.S. Route 221 exist. In order from south to north they are as follows. U.S. Route 221 Truck (US 221 Truck) directs truck drivers...

In the U.S. state of North Carolina U.S. Route 221 (US 221) is a north–south highway that travels through Western North Carolina. From Chesnee, South...

U.S. Route 221 (US 221) in Florida is a north–south United States Highway. It runs 40 miles (64 km) from Perry northwest to the Georgia State Line in Taylor...

U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia. In Virginia, the U.S. Highway runs...

U.S. Route 221 (US 221) in the U.S. state of Georgia is a south–north U.S. Highway. It travels from the Florida border near the Quitman area to the South...

U.S. Route 441 (US 441) is a 939-mile-long (1,511 km) auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top...

In the U.S. state of South Carolina, U.S. Route 221 (US 221) is a 126.390-mile (203.405 km) United States Highway within the state. It is part of the United...

North Carolina) Auxiliary routes of US 21: U.S. Route 121 U.S. Route 221 U.S. Route 321 U.S. Route 421 U.S. Route 521 U.S. roads portal United States...

Route 221 is a north–south highway in Quebec on the south shore of the St. Lawrence River, linking the US border south of Lacolle to Saint-Isidore. The...

U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

as State Route 221 (SR 221): Virginia State Route 221 (1923–1928), spur of SR 22 (now SR 311) to Catawba Hospital Virginia State Route 221 (1930–1933)...

Texas at an intersection with U.S. Route 90. US 285 has always had an endpoint in Denver, Colorado, although the original US 285 went north from Denver (that...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

State Route 221 (SR 221, OH 221) is a north–south state highway in southwestern Ohio, a U.S. state. Situated entirely in the southern portion of Brown...

U.S. Route 82 (US 82) is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern...

U.S. Route 90 or U.S. Highway 90 (US 90) is an east–west major United States highway in the Southern United States. Despite the "0" in its route number...

U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route...

U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula...

U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

eastern Bedford County, Virginia, United States. The community lies along U.S. Route 221 between Bedford and Forest. It is part of the Lynchburg Metropolitan...

U.S. Route 98 (US 98) is an east–west United States Highway in the Southeastern United States that runs from western Mississippi to southern Florida....

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

00 miles (9.66 km) from U.S. Route 221 (US 221), US 460, and US 220 Alternate in Roanoke north to Interstate 81 (I-81) and US 220 near Hollins. SR 115...

U.S. Route 341 (US 341) is a 224-mile-long (360 km) U.S. highway entirely in the U.S. state of Georgia. It travels diagonally across southern Georgia (but...