U.S. Route 74 (US 74) is an east–west United States highway that runs for 515 miles (829 km) from Chattanooga, Tennessee to Wrightsville Beach, North Carolina...

Several special routes of U.S. Route 74 exist. In order from west to east they are as follows. U.S. Route 74 Alternate (US 74A) was established in 1994...

U.S. Route 441 (US 441) is a 939-mile-long (1,511 km) auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 74 Alternate (US 74A or US 74-A) is an alternate route of U.S. Route 74 in Western North Carolina, running from the town of Forest City to the...

U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United...

U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs 1,099 miles (1,769 km) from Biddles Corner, Delaware...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 17 or U.S. Highway 17 (US 17), also known as the Coastal Highway, is a north–south United States Numbered Highway that spans in the Southeastern...

U.S. Route 89A is a 91.74-mile (147.64 km) north–south auxiliary U.S. highway (though its actual direction of travel is more east–west) in southwestern...

U.S. Route 29 or U.S. Highway 29 (US 29) is a north–south United States Numbered Highway that runs for 1,043.3 miles (1,679.0 km) from Pensacola, Florida...

U.S. Route 9 (US 9) is a north–south United States Numbered Highway in the states of Delaware, New Jersey, and New York in the Northeastern United States...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

State Route 74 (SR 74), part of which forms the Palms to Pines Scenic Byway or Pines to Palms Highway, and the Ortega Highway, is a state highway in the...

U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is...

U.S. Route 129 (US 129) is an auxiliary route of US 29, which it intersects in Athens, Georgia. US 129 currently runs for 582 miles (937 km) from an intersection...

U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways...

U.S. Route 28 (US 28) was an east–west United States Numbered Highway that was located completely in the U.S. state of Oregon. It connected US 99 in Eugene...

U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern...

AASHTO to remove US 311 from the southernmost 37 miles (60 km) of the route, being mostly redundant to I-74, bringing it to its current routing from Winston-Salem...

U.S. Route 111 (US 111) was a U.S. Highway that extended from Baltimore, Maryland north to the Harrisburg, Pennsylvania area. It replaced part of the...

U.S. Route 250 (US 250) is a route of the United States Numbered Highway System, and is a spur of U.S. Route 50. It currently runs for 514 miles (827 km)...

U.S. Route 15 or U.S. Highway 15 (US 15) is a 791.71-mile-long (1,274.13 km) United States Numbered Highway, serving the states of South Carolina, North...