The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune...

molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface...

positive signal in the activated CD4+ T cells and not in the quiescent cells which lack FcγR expression. Fc receptor-like molecule Anderson R (2003)....

co-receptor for HIV viral infection. The HIV envelope glycoprotein GP120 binds to CD4 as its primary receptor, CCR5 then forms a complex with CD4 and...

that binds to the CD4 receptor CCR5, a second receptor found on the surface of CD4+ cells and macrophages, called a chemokine co-receptor CXCR4, another...

CAR T cells can bear either of two types of co-receptors, CD4 and CD8. These two cell types, called CD4+ and CD8+, respectively, have different and interacting...

specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on...

belongs to the antibody (Ig) gene family. CD4 is a surface receptor for human immunodeficiency virus (HIV). The CD4 immunoadhesin molecular fusion allow the...

double-negative, as they express neither the CD4 nor CD8 co-receptor. The newly arrived CLP cells are CD4−CD8−CD44+CD25−ckit+ cells, and are termed early...

non-immunosuppressive humanised monoclonal antibody that binds CD4, the primary receptor for HIV, and inhibits HIV from entering cells. It is a post-attachment...

cells that are CD4 negative. This CD4-independence is associated with spontaneous mutation in the env gene. The presence of a co-receptor, CXCR4, is sufficient...

receptor) and then upregulation of CD4 only. Thymocytes that start receiving signal again are those that recognise MHC class II, and they become CD4+...

the plasma membrane by associating with the co-receptor CD4 or CD8, depending on the T-cell subtype. CD4 is expressed on helper T cells and regulatory...

Institute of Cancer Research. He is a co-discoverer of the CD4 receptor as the major cellular receptor for HIV. In 1986, he was appointed to a consulting position...

host tropism for CD4 related immune cells (e.g. T helper cells, macrophages or dendritic cells). These cells express a CD4 receptor, to which HIV can...

different T-Cell Receptor (TCR) co-receptors. MHC class II molecules in humans have five to six isotypes. Classical molecules present peptides to CD4+ lymphocytes...

peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor. Phalloidin - A very toxic polypeptide isolated mainly from Amanita phalloides...

instance, HIV-1 requires target cells to express co-receptors CCR5 or CXCR4, on top of the CD4 receptor for productive viral attachment. Interestingly, HIV-1...

functionally stable TCRs express both the CD4 and CD8 co-receptors and are therefore termed "double-positive" (DP) T cells (CD4+CD8+). The double-positive T cells...

complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It...

T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form a unique...

strains (NSI) use the beta-chemokine receptor CCR5 for entry and are thus able to replicate in macrophages and CD4+ T-cells. These strains are now called...

for both CD4 and chemokine receptors. The first step in fusion involves the high-affinity attachment of the CD4 binding domains of gp120 to CD4. Once gp120...

CD4+ or CD8+ and usually express CD45RO and at the same time lack CD45RA. Central memory T cells (TCM cells) express CD45RO, C-C chemokine receptor type...

tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively, to assist signaling from the T cell receptor (TCR) complex...

the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine...

CD28, which is on the surface of all naïve CD4+ and CD8+ T-lymphocytes, can bind ligands CD80 and CD86). Receptor-ligand engagement triggers T-cell signaling...

Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (July 1988). "The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58)...

through T-cell surface receptors designated "CD4" and "CCR5". Attempts to interfere with the binding of HIV with the CD4 receptor have failed to stop HIV...

both germline-encoded interactions between TCR and MHC and co-receptor interactions with CD4 or CD8 to signal T cell maturation occur during selection. The...