Common gamma chain (redirect from IL2RG)
gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. The human IL2RG gene is located on the long (q) arm of the X chromosome at position...
16 KB (2,092 words) - 14:33, 22 June 2024
consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic...
23 KB (2,548 words) - 17:16, 27 August 2024
associated with immunodeficiency diseases include CD40L, CD40, RAG1, RAG2, IL2RG, and ADA. Here is a summary of some methods utilized to identify genetic...
23 KB (2,168 words) - 06:54, 10 June 2024
recessive inheritance trait, stemming from a mutated (abnormal) version of the IL2RG gene located on the X-chromosome. This gene encodes the interleukin receptor...
36 KB (4,335 words) - 20:14, 12 July 2024
combined immunodeficiency Most cases of SCID are due to mutations in the IL2RG gene encoding the common gamma chain (γc) (CD132), a protein that is shared...
34 KB (3,270 words) - 01:33, 14 August 2024
the disease in Arabian horses and SCID mice. X-SCID in dogs (caused by IL2RG mutation) is seen in Basset Hounds and Cardigan Welsh Corgis. Because it...
11 KB (1,429 words) - 01:31, 14 August 2024
large amounts induce fever IL-2 Th1-cells CD25/IL2RA, CD122/IL2RB, CD132/IL2RG activated T cells and B cells, NK cells, macrophages, oligodendrocytes stimulates...
45 KB (4,194 words) - 12:36, 2 May 2024
Cytokine receptor common subunit gamma, or gamma subunit of IL-2 receptor (IL2RG). Gene mutation can cause rare x-linked immunodeficiency. CD133 Prominin-1...
96 KB (467 words) - 19:33, 6 August 2024
gene encoding the interleukin 2 receptor gamma chain (IL2Rγ, homologous to IL2RG in humans). IL2Rγ is a common component of the cell surface receptors that...
15 KB (1,429 words) - 22:04, 17 June 2024
breakthrough in this field came with the introduction of the mutant IL-2 receptor (IL2rg) gene in the NOD-scid model. This accounted for the creation of the NOD-scid-γcnull...
30 KB (3,633 words) - 21:41, 14 June 2024
receptor, gamma chain (severe combined immunodeficiency) Identifiers Symbol IL2RG Alt. symbols SCIDX1, IMD4, CD132 NCBI gene 3561 HGNC 6010 OMIM 308380 RefSeq...
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HGNC:6001 P60568 7562 IL2RA HGNC:6008 P01589 7563 IL2RB HGNC:6009 P14784 7564 IL2RG HGNC:6010 P31785 7565 IL3 HGNC:6011 P08700 7566 IL3RA HGNC:6012 P26951 7567...
277 KB (17 words) - 18:41, 6 October 2024
interleukin 2 receptor, gamma Identifiers Symbol IL2RG Alt. symbols SCIDX1, IMD4, CD132 NCBI gene 3561 HGNC 6010 OMIM 308380 RefSeq NM_000206 UniProt...
6 KB (550 words) - 00:43, 19 August 2023
complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines...
8 KB (1,118 words) - 09:22, 27 March 2022
structure prediction". AlphaFold Protein Structure Database. EMBL-EBI. "IL2RG interleukin 2 receptor subunit gamma [Homo sapiens (human)]". NCBI Gene...
12 KB (1,093 words) - 01:50, 4 November 2023
IgE production. The syndrome is caused by mutations in the RAG1, RAG2, IL2RG, IL7RA or RMRP genes. The number of immune cells is usually normal in this...
21 KB (2,440 words) - 15:06, 23 May 2024
have been examined. These include PDHA1, PDHA1, Xq21.3, Xq13.3, Zfx, Fix, Il2rg, Plp, Gk, Ids, Alas2, Rrm2p4, AmeIX, Tnfsf5, Licam, and Msn. The time to...
34 KB (4,559 words) - 06:26, 28 July 2024
two-member family for conserved putative interleukin 2 receptor gamma chain (Il2rg) domains. Additionally, human CXorf65 is one of 413 genes which belong to...
15 KB (1,266 words) - 17:54, 23 August 2024
immunodeficient NSG host strain (aka, NOD scid gamma; NOD.Cg-Prkdc<scid> Il2rg<tm1>Wjl/SzJ) mice developed at The Jackson Laboratory. MMHCdb allows researchers...
9 KB (1,005 words) - 03:25, 27 June 2024
2 receptor, gamma (severe combined immunodeficiency) Identifiers Symbol IL2RG Alt. symbols SCIDX1, IMD4 NCBI gene 3561 HGNC 6010 OMIM 308380 RefSeq NM_000206...
7 KB (690 words) - 06:50, 29 April 2024
familial; 144250; LPL Combined immunodeficiency, X-linked, moderate; 312863; IL2RG Combined malonic and methylmalonic aciduria (CMAMMA); 614265; ACSF3 Combined...
234 KB (18,877 words) - 15:43, 9 May 2024
arthritis. Janus kinase 3 has been shown to interact with CD247, TIAF1 and IL2RG. GRCh38: Ensembl release 89: ENSG00000105639 – Ensembl, May 2017 GRCm38:...
41 KB (5,166 words) - 16:45, 28 January 2023