are known, 2-imidazolines, 3-imidazolines, and 4-imidazolines. The 2- and 3-imidazolines contain an imine center, whereas the 4-imidazolines contain an...
917 bytes (91 words) - 12:20, 28 October 2022
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of imidazoline receptor: I1...
13 KB (1,312 words) - 21:25, 13 March 2024
2-Imidazoline (Preferred IUPAC name: 4,5-dihydro-1H-imidazole) is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula...
10 KB (902 words) - 20:21, 28 August 2022
peripheral vasomotor structures. Rilmenidine shows greater selectivity for imidazoline receptors than for cerebral alpha2-adrenergic receptors, distinguishing...
8 KB (758 words) - 21:47, 29 June 2024
Moxonidine (category Imidazolines)
Moxonidine (INN) is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of mild to moderate essential...
10 KB (877 words) - 19:28, 20 December 2023
example of autoreceptor. However, it is now known that clonidine binds to imidazoline receptors with a much greater affinity than α2 receptors, which would...
25 KB (2,231 words) - 23:55, 13 July 2024
symptoms). Selected examples are: Clonidine (mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine Fadolmidine Guanfacine, (preference...
13 KB (1,364 words) - 06:38, 1 April 2024
Tetryzoline (category Imidazolines)
ingested the drug. There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated. With treatment...
14 KB (1,147 words) - 11:06, 3 July 2024
Agmatine (category Imidazoline agonists)
targets: Neurotransmitter receptors and receptor ionophores. Nicotinic, imidazoline I1 and I2, α2-adrenergic, glutamate NMDAr, and serotonin 5-HT2A and 5HT-3...
18 KB (1,932 words) - 05:25, 1 July 2024
Clonidine (category Imidazolines)
vascular resistance.: 201–203 Clonidine also acts as an agonist at imidazoline-1 (I1) receptors in the brain, and it is hypothesized that this effect...
60 KB (5,506 words) - 21:49, 10 July 2024
Idazoxan (category Imidazoline antagonists)
selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as an antidepressant...
7 KB (619 words) - 21:18, 2 April 2024
certain oral medications (e.g., sympathomimetic amines and various 2-imidazolines) that constrict blood vessels in the lining of the nose, although evidence...
12 KB (1,166 words) - 12:09, 30 June 2024
Benzimidazole, an analog with a fused benzene ring Dihydroimidazole or imidazoline, an analog where the 4,5-double bond is saturated Pyrrole, an analog...
25 KB (2,517 words) - 13:52, 17 May 2024
Xylometazoline (category Imidazolines)
2868802A, Hüni, Albrecht, "2-(γ-TERT-BUTYL-O,O'-DIMETHYL-PHENYL-METHYL)-IMIDAZOLINE AND SALTS", issued 1959-01-13, assigned to Ciba Pharmaceutical Products...
13 KB (1,079 words) - 12:12, 6 August 2024
Oxymetazoline (category Imidazolines)
(NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%. Since imidazolines are sympathomimetic agents, their primary effects appear on α adrenergic...
15 KB (1,266 words) - 05:55, 14 May 2024
molecule: Amino acids (Arg) Arginine Arg, R α2-Adrenergic receptors, imidazoline receptors NMDA receptors Small: Amino acids Aspartate Asp, D – NMDA receptors...
94 KB (8,341 words) - 08:44, 9 August 2024
ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed...
5 KB (417 words) - 23:25, 25 March 2024
Tolonidine (category Imidazolines)
Tolonidine is an antihypertensive. It is an imidazoline receptor agonist, like moxonidine and rilmenidine. Clonidine Cosnier, D.; Duchene-Marullaz, P...
3 KB (156 words) - 07:47, 4 December 2023
the σ1 receptor (Ki = 3.2 nM) and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). Clorgiline is also a multidrug efflux pump inhibitor...
6 KB (403 words) - 14:37, 29 October 2023
W.C.; Liu, I.M.; Chung, H.H.; Cheng, J.T. (2008). "Activation of I2-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed...
15 KB (1,473 words) - 11:33, 26 June 2024
receptor modulators Nicotinic acetylcholine receptor modulators Others: Imidazoline receptor modulators Purine receptor modulators Sigma receptor modulators...
33 KB (3,391 words) - 00:41, 16 August 2024
easily. Cationic emulsifiers primarily include long-chain amines such as imidazolines, amido-amines, and diamines, which acquire a positive charge when an...
96 KB (12,027 words) - 20:58, 13 August 2024
Nutlin (category Imidazolines)
Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical...
7 KB (657 words) - 15:17, 20 May 2024
ATC code C04 (section C04AB Imidazoline derivatives)
ATC code C04 Peripheral vasodilators is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes...
2 KB (265 words) - 15:39, 25 January 2024
fungicides under the brand names Maneb, Mancozeb, Zineb, and Metiram. Some imidazoline-containing fungicides are derived from ethylenediamine. Ethylenediamine...
13 KB (1,053 words) - 15:25, 26 January 2024
receptor agonists agomelatine, melatonin, ramelteon, tasimelteon Imidazoline receptor Imidazoline receptor agonists apraclonidine, clonidine, moxonidine, rilmenidine...
84 KB (8,291 words) - 01:37, 18 August 2024
α2A-adrenergic receptor but also α2B- and α2C-adrenergic receptors and the imidazoline receptor. It is weaker than clonidine in producing hypotension and sedation...
43 KB (3,962 words) - 20:10, 8 August 2024
Mazindol (category Imidazolines)
affinity and substantially reduces DAT and SERT affinity. Expansion of the imidazoline ring system in mazindol to the corresponding six-membered homolog increases...
18 KB (1,379 words) - 20:25, 11 March 2024
↑intracellular Ca2+ → ↑NOS activity → ↑NO → (see nitric oxide) L-arginine imidazoline and α-2 receptor? Gi → ↓cAMP → activation of Na+/K+-ATPase → ↓intracellular...
44 KB (4,094 words) - 00:00, 8 August 2024
Products containing nicotine such as cigarettes, chewing tobacco or gum Imidazolines such as clonidine, naphazoline, oxymetazoline and tetrahydrozoline Antipsychotics...
6 KB (476 words) - 15:12, 18 April 2024