• Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial...
    32 KB (3,791 words) - 18:56, 19 August 2024
  • Thumbnail for Anti-cardiolipin antibodies
    Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid...
    5 KB (486 words) - 01:52, 12 August 2023
  • Thumbnail for Anti-mitochondrial antibody
    with anti-mitochondrial antibodies have been identified. M1 – cardiolipin (Anti-cardiolipin antibodies, ACA) M2 – branched-chain alpha-keto acid dehydrogenase...
    5 KB (500 words) - 10:03, 21 October 2023
  • musculature and muscle weakness, growth delay, exercise intolerance, cardiolipin abnormalities, and 3-methylglutaconic aciduria. It can be associated...
    16 KB (1,660 words) - 10:16, 18 May 2024
  • Thumbnail for Rapid plasma reagin
    against substances released by cells when they are damaged by T. pallidum (cardiolipin and lecithin). Traditionally, syphilis serologic testing has been performed...
    5 KB (532 words) - 15:02, 5 March 2024
  • Thumbnail for Venereal Disease Research Laboratory test
    extract of ox heart (diphosphatidyl glycerol). It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test...
    6 KB (670 words) - 13:13, 24 January 2024
  • Thumbnail for Antiphospholipid syndrome
    detect lupus anticoagulant, anti-apolipoprotein antibodies, and/or anti-cardiolipin antibodies. Antiphospholipid syndrome can be primary or secondary. •...
    37 KB (3,944 words) - 04:58, 16 August 2024
  • Thumbnail for Mitochondrial trifunctional protein
    MTP did indeed have cardiolipin remodeling capabilities. This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation...
    6 KB (589 words) - 15:55, 17 May 2024
  • Thumbnail for Citicoline
    after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2. It can also work to restore cardiolipin levels in the inner mitochondrial...
    19 KB (1,857 words) - 18:39, 11 June 2024
  • Thumbnail for Phosphatidylglycerol
    CDP-DAG forming cardiolipin releasing CMP by the action of cardiolipin synthase.[citation needed] Two phosphatidylglycerols form cardiolipin, the constituent...
    4 KB (456 words) - 08:50, 30 June 2024
  • Thumbnail for Tafazzin
    phospholipid:diacylglycerol acyltransferases). It catalyzes remodeling of immature cardiolipin to its mature composition containing a predominance of tetralinoleoyl...
    58 KB (6,767 words) - 17:30, 31 July 2024
  • Thumbnail for Elamipretide
    reduce the production of toxic reactive oxygen species and stabilize cardiolipin. Stealth Peptides, a privately held company, was founded in 2006 to develop...
    5 KB (208 words) - 04:15, 3 April 2023
  • Thumbnail for Mitochondrion
    Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered in cow hearts in 1942, and...
    166 KB (18,360 words) - 18:19, 4 August 2024
  • Thumbnail for Cytochrome c
    mitochondrial ROS production is stimulated, and cardiolipin is oxidized by a peroxidase function of the cardiolipin–cytochrome c complex. The hemoprotein is...
    33 KB (3,823 words) - 05:09, 22 July 2024
  • monolysocardiolipin (MLCL) into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which was then...
    6 KB (635 words) - 17:47, 7 July 2024
  • Thumbnail for Cytochrome c oxidase
    homodimer. This is required for activity. Dimers are connected by a cardiolipin molecule, which has been found to play a key role in stabilization of...
    36 KB (3,606 words) - 08:27, 15 July 2024
  • particular requires the presence of cardiolipin, a unique mitochondrial lipid. In yeast mitochondria lacking cardiolipin, the number of enzymes forming respiratory...
    15 KB (1,566 words) - 05:23, 4 January 2024
  • Thumbnail for Symbiogenesis
    mitochondria and chloroplasts, and also bacterial cell membranes; and that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell...
    70 KB (7,517 words) - 19:12, 17 July 2024
  • Thumbnail for Phospholipid scramblase
    biosynthesis of cardiolipin in mitochondria, and its overexpression in cultured cells resulted in increased cardiolipin synthase activity. As cardiolipin is synthesized...
    16 KB (1,688 words) - 00:01, 8 June 2024
  • Thumbnail for Lupus
    anticoagulant-positive". Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[citation...
    119 KB (13,047 words) - 02:23, 25 July 2024
  • Sodium oxide (NaO) Nonyl Acridine Orange, a fluorescent die. It can stain cardiolipin content of mitochondria. North Atlantic oscillation, a climatic phenomenon...
    1 KB (218 words) - 20:16, 7 October 2023
  • generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e....
    16 KB (1,868 words) - 01:25, 2 August 2024
  • Thumbnail for ATP synthase
    ATP synthases, but the FO subcomplex has many unique subunits. It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida...
    33 KB (3,752 words) - 15:11, 10 June 2024
  • Thumbnail for Apoptosis
    acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861–31870. doi:10...
    91 KB (10,659 words) - 18:05, 21 August 2024
  • Thumbnail for Wassermann test
    blood or cerebrospinal fluid is taken and introduced to the antigen – cardiolipin extracted from bovine muscle or heart. Syphilis non-specific antibodies...
    6 KB (483 words) - 15:10, 24 January 2024
  • knee Anterior cruciate ligament injury, a common sports injury Anti-cardiolipin antibodies ATP citrate synthase, or ATP citrate lyase, an enzyme ACL...
    2 KB (320 words) - 10:06, 29 July 2024
  • Thumbnail for Thrombophilia
    erythematosus but often detected in people without the disease), anti-cardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies; it is therefore regarded...
    47 KB (5,604 words) - 14:51, 4 August 2024
  • Thumbnail for PLSCR3
    that cardiolipin is a likely player in mitochondrial apoptosis. In a study done by R Lee et al., it was found that during apoptosis, cardiolipin in the...
    8 KB (1,032 words) - 07:16, 3 June 2024
  • Thumbnail for Inner mitochondrial membrane
    phospholipid composition. Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria,...
    8 KB (908 words) - 22:54, 15 February 2024
  • Thumbnail for Apolipoprotein H
    the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure...
    12 KB (1,419 words) - 19:08, 13 August 2023