Lumacaftor (VX-809) is a pharmaceutical drug that acts as a chaperone during protein folding and increases the number of CFTR proteins that are trafficked...
4 KB (171 words) - 13:20, 28 March 2024
Lumacaftor/ivacaftor, sold under the brand name Orkambi among others, is a combination of lumacaftor and ivacaftor used to treat people with cystic fibrosis...
15 KB (1,370 words) - 07:39, 4 July 2024
cases of cystic fibrosis. It is also included in combination medications, lumacaftor/ivacaftor, tezacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor...
34 KB (3,164 words) - 01:45, 12 October 2024
year. Vertex also studied ivacaftor in combination with another drug (lumacaftor) for the most common mutation in cystic fibrosis (CF), known as F508del...
37 KB (3,630 words) - 01:25, 19 October 2024
States. In July 2015, the U.S. Food and Drug Administration approved lumacaftor/ivacaftor. In 2018, the FDA approved the combination ivacaftor/tezacaftor;...
161 KB (18,189 words) - 19:11, 5 November 2024
combinations R07AX01 Nitric oxide R07AX02 Ivacaftor R07AX30 Ivacaftor and lumacaftor R07AX31 Ivacaftor and tezacaftor R07AX32 Ivacaftor, tezacaftor and elexacaftor...
1,000 bytes (237 words) - 06:04, 4 January 2021
Iobenguane I 131 Progenics Pharmaceuticals pheochromocytoma or paraganglioma Lumacaftor/ivacaftor Vertex Pharmaceuticals cystic fibrosis Mogamulizumab-kpkc Kyowa...
34 KB (180 words) - 17:05, 14 October 2024
impossible. Negulescu also led the discovery of another cystic fibrosis drug, lumacaftor, which is known as a "corrector" as it acts as a chaperone to help the...
19 KB (1,496 words) - 21:41, 21 June 2024
people in the world to be treated by the second new cystic fibrosis drug lumacaftor/ivacaftor which treats the most common mutation of CF. The drug has proven...
13 KB (1,103 words) - 09:04, 25 September 2024
19/3/2018 Make Orkambi available on the NHS for people with Cystic Fibrosis Lumacaftor/ivacaftor Debate video Hansard 26/3/2018 Change the GCSE English Literature...
29 KB (566 words) - 17:44, 31 October 2024
Marco; Colombo, Carla; Davies, Jane C.; De Boeck, Kris (2015-07-16). "Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR"...
32 KB (3,391 words) - 17:31, 15 September 2024
successfully advocated for health insurance coverage of treatment with lumacaftor/ivacaftor in the Netherlands. "Akte van oprichting van Stichting Openbaar...
10 KB (719 words) - 05:25, 26 September 2024
to subsequent discovery of Orkambi, the combination of Ivacaftor and Lumacaftor(VX-809), approved to treat CF in people with two copies of the F508del...
10 KB (964 words) - 21:17, 14 September 2024