The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin...

of the MC1R do sometimes display freckles. Even so, individuals with a high number of freckling sites have one or more of variants of the MC1R gene. Of...

recessive allele on chromosome 16 that produces an altered version of the MC1R protein. Red hair varies in hue from a deep burgundy or bright copper, or...

et al. (2007), dog coat color can largely be explained by three genes: MC1R, Agouti and CBD103. When a dog has wild-type alleles at all three genes,...

mutation at MC1R, it will also have a yellow coat, regardless of the genotypes at the other two loci. Dogs carrying wild-type alleles for MC1R and Agouti...

giving them an evolutionary advantage over other species. Research on the MC1R alleles using assumptions about past population size and an absence of population...

functional MC1R proteins are inherited dominantly and result in a black-based coat color ("E"), while mutated alleles that create "dysfunctional" MC1R are recessive...

chemical, Agouti signalling peptide (ASP), can attach itself to MC1R and interfere with MSH/MC1R signalling. In many mammals, variation in the level of ASP...

bp deletion from their melanocortin 1 receptor (MC1R) gene; with the specific allele referred to as MC1R∆24. A study published by BMC Evolutionary Biology...

endogenous agonists of MC1R.: 1175  Agouti signaling protein (ASIP) appears to be the only endogenous antagonist of MC1R. Synthetic MC1R agonists have been...

potential manifestation of a gene mutation in the melanocortin 1 receptor (MC1R). While red hair most frequently occurs among European peoples, it is also...

black or brindle/dun.: 200  The coat colours are caused by alleles at the MC1R gene (E locus) and the PMEL or SILV gene (D locus). They have an unusual...

color in humans; for instance, mutations in the melanocortin 1 receptor (MC1R) gene can lead to red or auburn hair, and exposure to ultraviolet radiation...

mutations in the melanocortin 1 receptor (MC1R) disrupt the pattern. The majority of pig breeds carry MC1R mutations disrupting wild-type colour and different...

PMID 29677510. Rogers AR, Iltis D, Wooding S (2004). "Genetic variation at the MC1R locus and the time since loss of human body hair". Current Anthropology....

affinities, tissue and cell type expression, and downstream functions (Figure 2). MC1R is expressed on melanocytes, macrophages, epithelial cells, endothelial cells...

population of non-albino white coyotes in Newfoundland owe their coloration to a MC1R mutation inherited from Golden Retrievers. Some 15% of 10,000 coyotes taken...

copies of a recessive gene on chromosome 16 which causes a mutation in the MC1R protein. Red hair varies from a deep burgundy through burnt orange to bright...

down many colors and patterns to their offspring. The domestic cat genes MC1R and ASIP allow color variety in their coats. The feline ASIP gene consists...

mutation in the MC1R gene that resulted in a loss-of-function of the MC1R protein. Without the ability to produce a functional MC1R protein, eumelanin...

missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses". Mammalian Genome...

testing combined with citizen science reveals a recently characterized ancient MC1R mutation associated with partial recessive red phenotypes in dog". Canine...

February 2023. Sheila M. Schmutz, Dayna L. Dreger (2013). Interaction of MC1R and SILV alleles on solid coat colors in Highland Cattle. Animal Genetics...

and eyes. Rather, a single, nonsynonymous nucleotide substitution in the MC1R gene causes melanin to not be produced. This mutant gene is recessive, so...

of the Arctic fox population is the white morph. Two similar mutations to MC1R cause the blue color and the lack of seasonal color change. The fur of the...

Amber, a mutation at the extension locus E/e (the melanocortin 1 receptor, MC1R) changes black pigment to amber or light amber, similar in appearance to...

the two common gene variants known to be associated with pale human skin, Mc1r does not appear to have undergone positive selection, while SLC24A5 has undergone...

eumelanin (black pigment) to phaeomelanin (red pigment)—which is encoded by the MC1R gene. There are five known variants in modern humans of the gene which cause...

receptor system each with differing specificities for melanocortins: MC1R. MC1R is associated with pigmentation genetics. MC2R. MC2R is also known as...

supporting "life jacket". A darker belly color may be caused by two mutations of MC1R. They appear to be more common in domestic reindeer herds. Blood moving into...