BRAF (gene) (redirect from V-raf murine sarcoma viral oncogene homolog B1)
a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is...
48 KB (5,285 words) - 16:26, 21 August 2024
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded...
69 KB (8,674 words) - 01:09, 28 March 2024
Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. A-Raf is a member of the Raf kinase family...
16 KB (1,985 words) - 12:57, 29 July 2023
RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains...
5 KB (556 words) - 08:06, 3 June 2024
most important upstream activators of this pathway are the Raf proteins (A-Raf, B-Raf or c-Raf), the key mediators of response to growth factors (EGF, FGF...
46 KB (5,492 words) - 14:52, 20 August 2024
MAPK/ERK pathway (redirect from Ras Raf Mek)
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the...
24 KB (3,068 words) - 07:21, 7 June 2024
The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the...
3 KB (263 words) - 22:01, 14 September 2023
mutations affecting the structure of the B-Raf protein, resulting in constitutive signaling through the Raf to MAP kinase pathway. A cause common to most...
154 KB (16,091 words) - 19:34, 29 August 2024
downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf, and receptors such as HER2. Mitogen-activated protein kinase...
11 KB (1,128 words) - 19:03, 18 September 2023
"New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors". Biochemical...
11 KB (1,074 words) - 21:50, 5 May 2024
to glutamic acid in the BRAF gene; this leads to an activation of the RAF protein which causes unlimited proliferative signalling in cancer cells. These...
35 KB (4,371 words) - 03:38, 14 August 2024
NS1 (section Non-structural protein 1)
NS 1, NS-1, NS.1, or variation, may refer to: NS1 influenza protein NS1 dengue protein, used for NS1 antigen test Human bocavirus NS1 Carnivore bocaparvovirus...
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anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase,...
4 KB (581 words) - 22:10, 16 October 2022
needed] Serine/threonine protein kinase p90-kDa ribosomal S6 kinase (RSK) is in involved in development of some prostate cancers. Raf inhibition has become...
14 KB (1,210 words) - 13:35, 14 June 2024
Philadelphia chromosome (redirect from Bcr-abl fusion protein)
region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...
29 KB (3,538 words) - 15:01, 5 December 2023
cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor...
11 KB (853 words) - 17:31, 10 April 2024
SHOC2 (category Proteins)
forming a holophosphatase complex that activates RAF proteins(PMID 16630891, 33526449). This protein was initially identified in Caenorhabditis elegans...
6 KB (689 words) - 02:12, 27 July 2022
HRAS (redirect from Transforming protein p21)
small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase like...
10 KB (1,338 words) - 02:39, 13 June 2024
Oncogene (redirect from Oncogene protein)
pathways. Downstream effectors of Ras include three mitogen-activated protein kinases Raf a MAP Kinase Kinase Kinase (MAPKKK), MEK a MAP Kinase Kinase (MAPKK)...
28 KB (3,173 words) - 16:31, 16 August 2024
cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans...
38 KB (4,865 words) - 20:29, 3 December 2023
phosphorylation of the small GTPase, Ras, or recruit the proteins of the ERK cascade directly (i.e., Raf-1, MEK, ERK-1/2) at which point signaling is initiated...
82 KB (9,384 words) - 18:56, 11 June 2024
MAP2K1 (redirect from Mitogen-activated protein kinase kinase 1)
"Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein". Mol. Cell. Biol. 20 (9). UNITED...
13 KB (1,478 words) - 04:12, 19 August 2024
Vemurafenib (category B-Raf inhibitors)
V600E BRAF mutation (that is, at amino acid position number 600 on the B-Raf protein, the normal valine is replaced by glutamic acid). About 60% of melanomas...
21 KB (1,808 words) - 04:37, 20 March 2024
arthritis (RA). 14-3-3 proteins bind to and sequester the transcriptional coregulators YAP/TAZ to the cytoplasm, inhibiting their function. Raf-1 Bad – see Bcl-2...
12 KB (1,318 words) - 09:59, 27 August 2024
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA...
27 KB (2,665 words) - 17:03, 6 April 2024
began to use genetic mouse models to investigate the role of the RAF family of protein kinases in control of intracellular signalling pathways involved...
6 KB (614 words) - 10:21, 7 April 2024
WRAMP structure using organelle proteomics. B-Raf signaling: In half of melanoma cells, the B-Raf protein contains a missense mutation (V600E mutation)...
13 KB (1,154 words) - 20:39, 12 March 2024
protein 1 is a protein that in humans is encoded by the PEBP1 gene. Phosphatidylethanolamine binding protein 1 has been shown to interact with: C-Raf...
8 KB (1,010 words) - 17:47, 23 December 2023
region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein. Erbin has been shown to interact with:...
13 KB (1,517 words) - 22:47, 15 December 2021
most of which involve the cAMP-dependent protein kinase (PKA) and the inhibition of Ras-dependent signals to Raf-1. However, cAMP can also stimulate cell...
16 KB (1,674 words) - 11:49, 16 November 2022