A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM...

pressure in check. mACE2 is cleaved by the enzyme ADAM17 in a process regulated by substrate presentation. ADAM17 cleavage releases the extracellular domain...

regulation of growth factor availability and mediating cell-matrix interactions. ADAM17 and ADAM15 have recently been identified in endothelial cells (EC). ADAMTS...

(metargidin)". Li Y, Brazzell J, Herrera A, Walcheck B (October 2006). "ADAM17 deficiency by mature neutrophils has differential effects on L-selectin...

PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". J Mammary Gland...

a short transmembrane domain, and a cytoplasmic tail. It is cleaved by ADAM17. The nature of the interactions between L-selectin and ligand depends on...

Disintegrin and metalloproteinase domain-containing protein 17; encoded by ADAM17 gene CD156c Disintegrin and metalloproteinase domain-containing protein...

PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (June 2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". Journal of Mammary...

H, Gierer S, Liepold T, Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry...

needed] the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy. It has been postulated that the activity...

only the prodomain is required for APP processing. Other ADAM proteins, ADAM17 (also called TACE, tumor necrosis factor-α converting enzyme), ADAM9, and...

CD163 function. sCD163 shedding occurs as a result of enzymatic cleavage by ADAM17. sCD163 is upregulated in a large range of inflammatory diseases including...

gene known to be involved in regulating response to low oxygen levels, ADAM17, is also found in human Tibetan highlanders. Over 81 million people live...

expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, the differentiation of pre-adipocytes...

time. Part of the ectodomain of TREM2 can be processed by enzymes (ADAM10, ADAM17) and released as a soluble version, called soluble TREM2 (sTREM2). This...

Philip; Putoczki, Tracy; Ernst, Matthias; Rose-John, Stefan (2 April 2018). "ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling"...

HGNC:189 O75078 255 ADAM12 HGNC:190 O43184 256 ADAM15 HGNC:193 Q13444 257 ADAM17 HGNC:195 P78536 258 ADAM18 HGNC:196 Q9Y3Q7 259 ADAM19 HGNC:197 Q9H013 260...

SARS-CoV-2 infection. The enzyme Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective...

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, acne) ADAM17 deficiency Blau syndrome Majeed syndrome (Chronic recurrent multifocal osteomyelitis...

carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17". British Journal of Cancer. 93 (11): 1267–76. doi:10.1038/sj.bjc.6602861...

catalyzing a reaction in a lipid raft but lacks a substrate for activity. (ADAM17), also called TACE, is sequestered into lipid rafts away from its substrate...

Interleukin-6 receptor can be cleaved from the cell membrane by the protease ADAM17 generating a soluble receptor. The soluble interleukin-6 receptor can still...

implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from the membrane and...

pathways, such as the Notch signaling pathway, through the upregulation of ADAM17. GRCh38: Ensembl release 89: ENSG00000105447 – Ensembl, May 2017 GRCm38:...

phosphorylated and ubiquitinated. MAPK1 has been shown to interact with: ADAM17, CIITA, DUSP1, DUSP3, ELK1, FHL2, HDAC4, MAP2K1, MAP3K1 MAPK14, MKNK1, MKNK2...

mice, iRhoms are key trafficking chaperones required for the ER export of ADAM17/TACE and its maturation. iRhoms are thus required for the TNF-alpha and...

desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis. Mol. Cell Biol. 26(13):5086-95...

proteolytic processing of the amyloid precursor protein. ADAM10, along with ADAM17, cleaves the ectodomain of the triggering receptor expressed on myeloid...

Dempsey PJ, Raines EW (2001). "Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)". J. Biol. Chem...

cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated...