Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases...
15 KB (1,669 words) - 21:07, 28 May 2024
Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase...
20 KB (2,455 words) - 05:41, 10 July 2024
CYP3A4 (redirect from Cytochrome P450 3A4)
Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in...
80 KB (7,794 words) - 21:26, 15 July 2024
This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes. In alphabetical order. List of steroid metabolism...
9 KB (78 words) - 09:09, 12 November 2023
CYP2D6 (redirect from Cytochrome P450 2D6)
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly...
47 KB (3,786 words) - 16:10, 12 July 2024
cytochrome classes, several additional classifications such as cytochrome o and cytochrome P450 can be found in biochemical literature. Cytochromes were...
10 KB (1,107 words) - 22:33, 2 January 2024
CYP1A2 (redirect from Cytochrome P450 1A2)
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics...
30 KB (2,813 words) - 09:58, 23 May 2024
CYP2E1 (redirect from Cytochrome P450 2E1)
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism...
25 KB (2,928 words) - 08:57, 19 June 2024
CYP1A1 (redirect from Cytochrome P450 1A1)
Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome...
15 KB (1,829 words) - 05:31, 1 July 2024
Cytochrome P450 BM3 is a Prokaryote Cytochrome P450 enzyme originally from Bacillus megaterium catalyzes the hydroxylation of several long-chain fatty...
2 KB (149 words) - 01:16, 14 November 2023
Cortisol is also metabolized irreversibly into 6β-hydroxycortisol by cytochrome p450-3A monooxygenases, mainly, CYP3A4. Drugs that induce CYP3A4 may accelerate...
78 KB (8,594 words) - 12:55, 16 August 2024
This article covers protein engineering of cytochrome (CYP) P450 enzymes. P450s are involved in a range of biochemical catabolic and anabolic process...
13 KB (1,351 words) - 04:07, 27 July 2024
Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive...
57 KB (5,140 words) - 13:01, 20 August 2024
CYP2B6 (category Cytochrome P450)
Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the cytochrome P450 group of enzymes. Along with CYP2A6...
20 KB (2,024 words) - 06:29, 10 July 2024
vortioxetine with the cytochrome P450 inhibitors ketoconazole and fluconazole. Rifampicin, a strong and broad cytochrome P450 inducer (though notably...
56 KB (4,794 words) - 11:06, 17 August 2024
possible potentiation of their effects and side effects by MAOIs. The cytochrome P450 enzymes involved in the metabolism of selegiline have not been fully...
193 KB (18,848 words) - 01:35, 20 August 2024
Tuta absoluta (section Cytochrome P450 and resistance)
Spinosad resistance was also first noticed in Chile (possibly thanks to a cytochrome P450 and esterases), and then spinosad/spinetoram cross-resistance in Brazil...
32 KB (3,333 words) - 14:16, 30 June 2024
methylenedioxy group. The oxidation of the allyl side chain is mediated by a cytochrome P450 complex, which will transform safrole into 1′-hydroxysafrole. The newly...
31 KB (3,454 words) - 08:10, 2 May 2024
Cimetidine (category Cytochrome P450 inhibitors)
massive overdoses (e.g., 20 g). Due to its non-selective inhibition of cytochrome P450 enzymes, cimetidine has numerous drug interactions. Examples of specific...
50 KB (5,133 words) - 06:01, 24 June 2024
metabolism is divided into three phases. In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These...
32 KB (3,618 words) - 16:03, 7 July 2024
CYP2C9 (redirect from Cytochrome P450 2C9)
Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both...
50 KB (5,023 words) - 03:04, 8 April 2024
In biochemistry, cytochrome P450 enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, and archaea, as well...
42 KB (4,485 words) - 22:27, 17 July 2024
morphine and less than oxycodone. Hydrocodone is metabolized by the cytochrome P450 enzymes CYP2D6 and CYP3A4, and inhibitors and inducers of these enzymes...
59 KB (5,325 words) - 04:56, 1 July 2024
drug interactions is the enzyme system comprising the cytochrome P450 oxidases. Cytochrome P450 is a very large family of haemoproteins (hemoproteins)...
29 KB (2,971 words) - 18:45, 23 June 2024
plays the most important role, followed by CYP2B6. In addition to the cytochrome P450 system, sertraline can be oxidatively deaminated in vitro by monoamine...
101 KB (10,398 words) - 08:07, 2 August 2024
Cytochrome P450 oxidoreductase deficiency (PORD) is a rare disease and inborn error of metabolism caused by deficiency of cytochrome P450 oxidoreductase...
6 KB (525 words) - 15:46, 10 December 2023
grapefruit. These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs...
55 KB (5,720 words) - 16:53, 17 August 2024
(EC50 >10 μM). In accordance, progesterone induces several hepatic cytochrome P450 enzymes, such as CYP3A4, especially during pregnancy when concentrations...
123 KB (11,581 words) - 15:07, 12 August 2024
inhibitor of CYP2C19, enzymes of the cytochrome P450 group of enzymes. Modafinil also induces or inhibits other cytochrome P450 enzymes. One in vitro study predicts...
169 KB (15,529 words) - 03:40, 18 August 2024
CYP2C19 (redirect from Cytochrome p-450 cyp2c19)
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system...
39 KB (3,879 words) - 02:14, 11 August 2024