by the SH2B1 gene. SH2B1 has been shown to interact with: Grb2, Insulin receptor, Janus kinase 2, and TrkA. Variations close to or in the SH2B1 gene have...
11 KB (1,468 words) - 05:52, 29 December 2023
Prader-Willi syndrome and monogenic obesity caused by mutations in the SH2B1, PCSK1, or SIM1 genes. "Product monograph brand safety updates". Health...
11 KB (892 words) - 04:28, 28 May 2024
NCK1; NCK2 PIK3R1; PIK3R2; PIK3R3; PLCG1; PLCG2; PTK6; PTPN11; PTPN6; RASA1 SH2B1; SH2B2; SH2B3; SH2D1A; SH2D1B; SH2D2A; SH2D3A; SH2D3C; SH2D4A; SH2D4B; SH2D5;...
13 KB (1,341 words) - 13:40, 20 November 2024
Q96HU1 14685 SGTA HGNC:10819 O43765 14686 SGTB HGNC:23567 Q96EQ0 14687 SH2B1 HGNC:30417 Q9NRF2 14688 SH2B2 HGNC:17381 O14492 14689 SH2B3 HGNC:29605 Q9UQQ2...
282 KB (17 words) - 08:00, 19 November 2024
itself, it does determine the location on the body where this fat is stored. SH2B1 16p11.2 MTCH2 11p11.2 PCSK1 5q15-q21 NPC1 18q11-q12 LYPLAL1 616548 1q41...
25 KB (2,298 words) - 21:22, 7 November 2024
EPOR FYN Grb2 GHR IRS1 IL12RB2 IL5RA PIK3R1 PPP2R4 PTK2 PTPN11 PTPN6 PRMT5 SH2B1 SHC1 SOCS3 STAT5A STAT5B STAM SOCS1 TEC TNFRSF1A VAV1 YES1 Prolactin signals...
28 KB (3,166 words) - 19:57, 8 August 2024
(neuronal) adaptor protein PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1 SH2B1 – SH2B adaptor protein 1 SH2B2 – SH2B adaptor protein 2 SH2B3 – SH2B adaptor...
6 KB (666 words) - 20:46, 24 January 2024
Nearby regions on chromosome 16 may also be affected. Notably, deletion of SH2B1 is associated with obesity and may be involved in the pathogenesis of obesity...
14 KB (1,064 words) - 23:48, 7 July 2024
shown to interact with ENPP1, GRB10, GRB7, IRS1, MAD2L1, PRKCD, PTPN11, and SH2B1. GRCh38: Ensembl release 89: ENSG00000171105 – Ensembl, May 2017 GRCm38:...
31 KB (3,785 words) - 19:26, 2 September 2024
RASAL1, RASGRF1, RGNEF, ROCK1, ROCK2, RTKN, SBF1, SBF2, SCAP2, SGEF, SH2B, SH2B1, SH2B2, SH2B3, SH3BP2, SKAP1, SKAP2, SNTA1, SNTB1, SNTB2, SOS1, SOS2, SPATA13...
14 KB (1,434 words) - 18:03, 6 October 2024
PTK2, PTPN11, PTPN12, PTPN1, PTPN6, PTPRA, RAPGEF1, RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich...
82 KB (9,365 words) - 15:39, 31 March 2024
to interact with: Abl gene, FRS2, Grb2, MATK, NGFB, PLCG1, RICS, SQSTM1, SH2B1, SH2B2, and SHC1. Small molecules such as amitriptyline and gambogic acid...
28 KB (3,328 words) - 15:54, 29 October 2024
NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese"...
6 KB (746 words) - 06:03, 25 July 2024
Morris DL, Rui L (2007). "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling"...
8 KB (994 words) - 00:01, 4 March 2023