U.S. Highway 18 (US 18) is an east–west United States Numbered Highway in the Midwestern United States. The western terminus is in Orin, Wyoming, at an...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide...

U.S. Highway 18 (US 18) is a part of the United States Numbered Highway System that travels from Orin, Wyoming, to Milwaukee, Wisconsin. In the state...

"north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each...

U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the...

U.S. Highway 18 (US 18) is the northernmost east–west United States Numbered Highway in the state of Iowa. As with all state highways in Iowa, it is maintained...

U.S. Route 30 or U.S. Highway 30 (US 30) is an east–west main route of the United States Numbered Highway System, with the highway traveling across the...

U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four...

U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S...

U.S. Route 425 (US 425) is a north–south United States highway that travels in the U.S. states of Mississippi, Louisiana, and Arkansas. It was first commissioned...

U.S. Route 95 (US 95) is a major north–south United States Highway in the western United States. It travels through the states of Arizona, California,...

U.S. Highway 18 (US 18) in the state of Wisconsin runs east–west across the southern part of the state. The highway serves as major connecting route between...

U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate...

U.S. Route 71 or U.S. Highway 71 (US 71) is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United...

U.S. Route 85 (US 85) is a 1,479-mile-long (2,380 km) north–south United States Highway that travels in the Mountain and Northern Plains states of the...

U.S. Highway 55 was a north–south United States highway. Though it was part of the original 1926 numbering plan, it was deleted within 10 years. From...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 191 (US 191) is a north–south highway in the Western United States and a spur of parent route U.S. Route 91 that has two segments. The southern...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66), is a major east–west United...

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England...

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 12 or U.S. Highway 12 (US 12) is an east–west United States Numbered Highway, running from Aberdeen, Washington, to Detroit, Michigan, for...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 491 (US 491) is a north–south U.S. Highway serving the Four Corners region of the United States. It was created in 2003 as a renumbering of...

U.S. Route 69 (US 69) is a major north–south United States highway in the central United States. When it was first created, it was only 150 miles (241 km)...