Vemurafenib (INN), sold under the brand name Zelboraf, is a medication used for the treatment of late-stage melanoma. It is an inhibitor of the B-Raf...
21 KB (1,815 words) - 16:50, 24 November 2024
BRAF (gene) (section Vemurafenib)
developed. Two of these drugs, vemurafenib and dabrafenib, are approved by FDA for treatment of late-stage melanoma. Vemurafenib was the first approved drug...
48 KB (5,285 words) - 16:26, 21 August 2024
Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib Imatinib Vemurafenib Vismodegib Azacitidine Azathioprine Capecitabine Cladribine Clofarabine...
5 KB (324 words) - 08:56, 9 December 2024
[citation needed] There are two FDA-approved targeted drugs to treat ECD. Vemurafenib, an oral agent approved in 2019, targets the BRAF protein. It was approved...
22 KB (2,230 words) - 07:46, 26 November 2024
metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. It is also indicated for the treatment of adults with histiocytic neoplasms...
12 KB (890 words) - 11:11, 31 December 2024
Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib. It can be treated with urea-containing creams, which...
11 KB (1,096 words) - 04:16, 7 August 2024
and vemurafenib 720 mg orally twice daily, or placebo in combination with cobimetinib 60 mg orally once daily (21 days on/7 days off) and vemurafenib 960 mg...
43 KB (4,183 words) - 04:17, 1 October 2024
monoclonal antibody approved to treat rheumatoid arthritis. 2011: Zelboraf (vemurafenib): For the treatment of metastatic melanoma caused by BRAF mutation. 2012:...
32 KB (2,876 words) - 17:09, 2 January 2025
plus encorafenib 450 mg once daily, encorafenib 300 mg once daily, or vemurafenib 960 mg twice daily. Treatment continued until disease progression or...
13 KB (1,054 words) - 21:06, 20 December 2024
EGFR gene. Some drugs are specifically approved for certain genotypes. Vemurafenib is such a case which is used for melanoma patients who carry a mutation...
33 KB (3,411 words) - 17:41, 4 January 2025
Cotreatment with CYP1A2 inhibitors like ciprofloxacin, fluvoxamine or vemurafenib can reduce chlorpromazine clearance and hence increase exposure and potentially...
64 KB (5,765 words) - 17:34, 4 January 2025
targeting agent. It is also being studied for use in combination with vemurafenib in patients with advanced BRAF V600-mutant solid tumors. "Tunlametinib"...
4 KB (174 words) - 02:57, 23 December 2024
additional $130 million in milestone payments, pending on the success of Vemurafenib (Plexxikon's lead program) an oral, novel drug that targets the oncogenic...
29 KB (2,365 words) - 00:42, 19 December 2024
[D-Lys(6)]- LHRH, Phase II results for ovarian cancer. Braf inhibitors (vemurafenib, dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF...
20 KB (2,234 words) - 01:21, 22 July 2024
asthma, chronic idiopathic urticaria (CIU), and nasal polyps. Zelboraf (vemurafenib), for late-stage V600E BRAF mutation-positive melanoma. Zenapax (daclizumab)...
67 KB (5,738 words) - 11:01, 31 December 2024
like ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; or a MEK inhibitor trametinib may be used. When arising...
24 KB (2,383 words) - 15:31, 14 November 2024
they are positive for the specific mutation. BRAF inhibitors, such as vemurafenib and dabrafenib and a MEK inhibitor trametinib are the most effective...
156 KB (16,312 words) - 20:10, 3 January 2025
agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. Important prognosis factors...
4 KB (386 words) - 15:36, 21 May 2024
the rate of keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. Keratoacanthomas presents as a fleshy, elevated and nodular...
12 KB (1,222 words) - 03:34, 7 December 2023
include SB590885, PLX4720, XL281, RAF265, encorafenib, dabrafenib, and vemurafenib. Some MEK inhibitors include cobimetinib, CI-1040, PD0325901, binimetinib...
24 KB (3,068 words) - 07:21, 7 June 2024
quinine Antibiotics macrolides fluoroquinolones Other drugs methadone vemurafenib pitolisant Some second-generation antihistamines, such as astemizole...
29 KB (3,277 words) - 05:30, 8 September 2024
ipilimumab, pembrolizumab, nivolumab, cemiplimab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. In February 2024, the...
58 KB (6,508 words) - 20:52, 6 December 2024
disease, then second-line therapy is pursued. BRAF inhibitors such as vemurafenib or dabrafenib inhibit the MAPK/ERK pathway which is constitutively active...
53 KB (6,579 words) - 17:52, 2 January 2025
DDX3X in melanoma is affected by vemurafenib via an undiscovered mechanism. It is unknown how the presence of vemurafenib downregulates DDX3X. However, reduced...
18 KB (1,859 words) - 03:29, 30 December 2024
myasthenia gravis. The combination of ipilimumab with either leflunomide or vemurafenib may lead to increased hepatotoxicity. Systemic corticosteroids should...
48 KB (4,684 words) - 06:38, 18 September 2024
survival and has been approved by the FDA. Another similar combination is vemurafenib and cobimetinib. Immunotherapy is also starting to play an important...
20 KB (2,157 words) - 22:06, 3 January 2025
L01EB09 Lazertinib L01EB10 Mobocertinib L01EB11 Aumolertinib L01EC01 Vemurafenib L01EC02 Dabrafenib L01EC03 Encorafenib L01ED01 Crizotinib L01ED02 Ceritinib...
13 KB (935 words) - 04:36, 23 December 2024
PARP inhibitor olaparib, veliparib -rafenib BRAF inhibitors sorafenib, vemurafenib -tinib Tyrosine-kinase inhibitors erlotinib, crizotinib -zomib proteasome...
26 KB (2,150 words) - 12:06, 11 September 2024
or XL518, approved by US FDA in Nov 2015 for use in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma with a BRAF V600E or...
6 KB (719 words) - 23:12, 12 May 2024
Veltane Veltassa Veltin veltuzumab (USAN) velusetrag (USAN, INN) Vemlidy vemurafenib (INN) Venclexta Venclyxto venlafaxine (INN) Venofer venritidine (INN)...
9 KB (506 words) - 04:57, 24 November 2024