• Thumbnail for Vemurafenib
    Vemurafenib (INN), sold under the brand name Zelboraf, is a medication used for the treatment of late-stage melanoma. It is an inhibitor of the B-Raf...
    21 KB (1,815 words) - 16:50, 24 November 2024
  • Thumbnail for BRAF (gene)
    developed. Two of these drugs, vemurafenib and dabrafenib, are approved by FDA for treatment of late-stage melanoma. Vemurafenib was the first approved drug...
    48 KB (5,285 words) - 16:26, 21 August 2024
  • Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib Imatinib Vemurafenib Vismodegib Azacitidine Azathioprine Capecitabine Cladribine Clofarabine...
    5 KB (324 words) - 08:56, 9 December 2024
  • Thumbnail for Erdheim–Chester disease
    [citation needed] There are two FDA-approved targeted drugs to treat ECD. Vemurafenib, an oral agent approved in 2019, targets the BRAF protein. It was approved...
    22 KB (2,230 words) - 07:46, 26 November 2024
  • Thumbnail for Cobimetinib
    metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. It is also indicated for the treatment of adults with histiocytic neoplasms...
    12 KB (890 words) - 11:11, 31 December 2024
  • Thumbnail for Hyperkeratosis
    Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib. It can be treated with urea-containing creams, which...
    11 KB (1,096 words) - 04:16, 7 August 2024
  • Thumbnail for Atezolizumab
    and vemurafenib 720 mg orally twice daily, or placebo in combination with cobimetinib 60 mg orally once daily (21 days on/7 days off) and vemurafenib 960 mg...
    43 KB (4,183 words) - 04:17, 1 October 2024
  • monoclonal antibody approved to treat rheumatoid arthritis. 2011: Zelboraf (vemurafenib): For the treatment of metastatic melanoma caused by BRAF mutation. 2012:...
    32 KB (2,876 words) - 17:09, 2 January 2025
  • Thumbnail for Encorafenib
    plus encorafenib 450 mg once daily, encorafenib 300 mg once daily, or vemurafenib 960 mg twice daily. Treatment continued until disease progression or...
    13 KB (1,054 words) - 21:06, 20 December 2024
  • Thumbnail for Drug
    EGFR gene. Some drugs are specifically approved for certain genotypes. Vemurafenib is such a case which is used for melanoma patients who carry a mutation...
    33 KB (3,411 words) - 17:41, 4 January 2025
  • Thumbnail for Chlorpromazine
    Cotreatment with CYP1A2 inhibitors like ciprofloxacin, fluvoxamine or vemurafenib can reduce chlorpromazine clearance and hence increase exposure and potentially...
    64 KB (5,765 words) - 17:34, 4 January 2025
  • Thumbnail for Tunlametinib
    targeting agent. It is also being studied for use in combination with vemurafenib in patients with advanced BRAF V600-mutant solid tumors. "Tunlametinib"...
    4 KB (174 words) - 02:57, 23 December 2024
  • Thumbnail for Daiichi Sankyo
    additional $130 million in milestone payments, pending on the success of Vemurafenib (Plexxikon's lead program) an oral, novel drug that targets the oncogenic...
    29 KB (2,365 words) - 00:42, 19 December 2024
  • Thumbnail for Targeted therapy
    [D-Lys(6)]- LHRH, Phase II results for ovarian cancer. Braf inhibitors (vemurafenib, dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF...
    20 KB (2,234 words) - 01:21, 22 July 2024
  • Thumbnail for Roche
    asthma, chronic idiopathic urticaria (CIU), and nasal polyps. Zelboraf (vemurafenib), for late-stage V600E BRAF mutation-positive melanoma. Zenapax (daclizumab)...
    67 KB (5,738 words) - 11:01, 31 December 2024
  • Thumbnail for Acral lentiginous melanoma
    like ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; or a MEK inhibitor trametinib may be used. When arising...
    24 KB (2,383 words) - 15:31, 14 November 2024
  • Thumbnail for Melanoma
    they are positive for the specific mutation. BRAF inhibitors, such as vemurafenib and dabrafenib and a MEK inhibitor trametinib are the most effective...
    156 KB (16,312 words) - 20:10, 3 January 2025
  • Thumbnail for Nodular melanoma
    agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. Important prognosis factors...
    4 KB (386 words) - 15:36, 21 May 2024
  • Thumbnail for Keratoacanthoma
    the rate of keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. Keratoacanthomas presents as a fleshy, elevated and nodular...
    12 KB (1,222 words) - 03:34, 7 December 2023
  • include SB590885, PLX4720, XL281, RAF265, encorafenib, dabrafenib, and vemurafenib. Some MEK inhibitors include cobimetinib, CI-1040, PD0325901, binimetinib...
    24 KB (3,068 words) - 07:21, 7 June 2024
  • Thumbnail for QT interval
    quinine Antibiotics macrolides fluoroquinolones Other drugs methadone vemurafenib pitolisant Some second-generation antihistamines, such as astemizole...
    29 KB (3,277 words) - 05:30, 8 September 2024
  • Thumbnail for Skin cancer
    ipilimumab, pembrolizumab, nivolumab, cemiplimab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. In February 2024, the...
    58 KB (6,508 words) - 20:52, 6 December 2024
  • Thumbnail for Hairy cell leukemia
    disease, then second-line therapy is pursued. BRAF inhibitors such as vemurafenib or dabrafenib inhibit the MAPK/ERK pathway which is constitutively active...
    53 KB (6,579 words) - 17:52, 2 January 2025
  • Thumbnail for DDX3X
    DDX3X in melanoma is affected by vemurafenib via an undiscovered mechanism. It is unknown how the presence of vemurafenib downregulates DDX3X. However, reduced...
    18 KB (1,859 words) - 03:29, 30 December 2024
  • Thumbnail for Ipilimumab
    myasthenia gravis. The combination of ipilimumab with either leflunomide or vemurafenib may lead to increased hepatotoxicity. Systemic corticosteroids should...
    48 KB (4,684 words) - 06:38, 18 September 2024
  • Thumbnail for Anaplastic thyroid cancer
    survival and has been approved by the FDA. Another similar combination is vemurafenib and cobimetinib. Immunotherapy is also starting to play an important...
    20 KB (2,157 words) - 22:06, 3 January 2025
  • L01EB09 Lazertinib L01EB10 Mobocertinib L01EB11 Aumolertinib L01EC01 Vemurafenib L01EC02 Dabrafenib L01EC03 Encorafenib L01ED01 Crizotinib L01ED02 Ceritinib...
    13 KB (935 words) - 04:36, 23 December 2024
  • PARP inhibitor olaparib, veliparib -rafenib BRAF inhibitors sorafenib, vemurafenib -tinib Tyrosine-kinase inhibitors erlotinib, crizotinib -zomib proteasome...
    26 KB (2,150 words) - 12:06, 11 September 2024
  • or XL518, approved by US FDA in Nov 2015 for use in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma with a BRAF V600E or...
    6 KB (719 words) - 23:12, 12 May 2024
  • Veltane Veltassa Veltin veltuzumab (USAN) velusetrag (USAN, INN) Vemlidy vemurafenib (INN) Venclexta Venclyxto venlafaxine (INN) Venofer venritidine (INN)...
    9 KB (506 words) - 04:57, 24 November 2024