Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. By intravenous...
31 KB (2,796 words) - 07:50, 10 August 2024
gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite. It has also been used in diatom selection...
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include fluorouracil and capecitabine. Fluorouracil is a nucleobase analogue that is metabolised in cells to form at least two active products; 5-fluourouridine...
155 KB (17,546 words) - 16:49, 16 August 2024
CMF (chemotherapy) (redirect from Cyclophosphamide methotrexate fluorouracil)
combines three anti-cancer agents: cyclophosphamide, methotrexate, and 5-fluorouracil (5-FU). While it is no longer considered the most efficient all-around...
3 KB (308 words) - 11:19, 15 March 2024
Actinic keratosis (section Fluorouracil cream)
by illumination with a strong light source. Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over...
71 KB (8,809 words) - 10:32, 18 September 2024
Folinic acid (redirect from 5-Formyltetrahydrofolic acid)
methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat...
18 KB (1,570 words) - 22:22, 23 July 2024
converted to 5-fluorouracil (5-FU) through which it acts. It belongs to the class of medications known as fluoropyrimidines, which also includes 5-FU and tegafur...
14 KB (1,105 words) - 06:03, 14 September 2024
applications, which in this context decreases the cytotoxicity of 5-fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates...
4 KB (411 words) - 21:05, 6 May 2024
tests have been given. Biochemist Marie Hakala, PhD first observed that 5-fluorouracil becomes more effective in treating cancer cells when calcium leucovorin...
34 KB (3,124 words) - 15:16, 25 July 2024
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by...
13 KB (1,455 words) - 06:49, 24 September 2024
care costs. For most cancer treatment, about 5–15% of patients get mucositis. However, with 5-fluorouracil (5-FU), up to 40% get mucositis, and 10–15% get...
21 KB (2,551 words) - 07:43, 3 June 2024
a vitamin B derivative that enhances the effects of 5-fluorouracil (5-FU); F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates...
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colorectal cancer, made up of the drugs folinic acid (leucovorin, FOL), fluorouracil (5-FU, F), and oxaliplatin (Eloxatin, OX). Adjuvant treatment in patients...
10 KB (1,337 words) - 04:46, 21 April 2023
drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®) Cytarabine (Ara-C®)...
12 KB (1,314 words) - 05:55, 8 July 2024
toxicity following exposure to 5-fluorouracil (5-FU), a chemotherapy drug that is used in the treatment of cancer. Beside 5-FU, widely prescribed oral fluoropyrimidine...
6 KB (677 words) - 22:22, 16 November 2023
Floxuridine (redirect from 5-fluoro-2'-deoxyuridine)
and stomach cancers. In vitro uses of floxuridine include 5-minute treatments of fluorouracil, floxuridine, and mitomycin to increase cell proliferation...
12 KB (1,274 words) - 06:04, 4 January 2024
of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU...
8 KB (621 words) - 12:45, 8 December 2023
Capecitabine Carmofur (HCFU) Doxifluridine Fluorouracil (5-FU) Tegafur Some metabolites of these drugs, such as 5-fluorodeoxyuridylate monophosphate, also...
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It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur. It also participates in beta-alanine metabolism and pantothenate...
12 KB (1,222 words) - 06:33, 23 September 2024
2° secondary 2/2 secondary to 3TC lamivudine 5-FU 5-fluorouracil 5-HIAA 5-hydroxyindoleacetic acid 5-HT 5-hydroxytryptamine, that is, serotonin 6MP 6-mercaptopurine...
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methotrexate. A common cytotoxic chemotherapy used in a variety of cancers, 5-fluorouracil (5-FU), targets the TYMS pathway and resistance can evolve through the...
87 KB (9,928 words) - 12:18, 13 August 2024
first studied in the 1970s. The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by multiple regimens using a host of other systemic...
58 KB (6,264 words) - 01:00, 29 September 2024
depending on whether 5-BrU is within the DNA molecule or is an incoming base when it is enolized or ionized. 5-Fluorouracil 5-Chlorouracil IUPAC-IUB...
4 KB (304 words) - 21:47, 11 December 2021
Fluorodeoxyuridylate (redirect from 5-Fluorodeoxyuridine monophosphate)
as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine...
11 KB (1,304 words) - 22:59, 30 March 2024
pharmaceutical. When elemental fluorine reacts with uracil, they produce 5-fluorouracil. 5-Fluorouracil is an anticancer drug (antimetabolite) used to masquerade as...
29 KB (2,943 words) - 09:59, 9 August 2024
Traditionally, chemotherapeutic adjuvants, such as mitomycin C (MMC) or 5-fluorouracil (5-FU), are applied with soaked sponges on the wound bed to prevent filtering...
90 KB (9,916 words) - 20:34, 10 September 2024
symptoms. This may include salicylic acid, cryotherapy, chemo-based fluorouracil or bleomycin, and surgical removal. The skin atop the lesion should generally...
17 KB (1,660 words) - 09:01, 17 July 2024
reactivity can be altered significantly. For example, both uracil and 5-fluorouracil are colourless, high-melting crystalline solids, but the latter is a...
41 KB (4,534 words) - 14:34, 22 September 2024
particularly vulnerable to the cytotoxic effects of chemotherapy agents. 5-fluorouracil has been demonstrated to reduce the viability of neural progenitor cells...
35 KB (4,146 words) - 17:59, 8 August 2024
is generally responsive to topic chemotherapy, such as imiquimod, or fluorouracil, although surgical treatment is better able to ensure complete removal...
53 KB (5,202 words) - 02:41, 13 August 2024